Article
Biochemistry & Molecular Biology
Gonzalo Ferreira, Axel Santander, Romina Cardozo, Luisina Chavarria, Lucia Dominguez, Nicolas Mujica, Milagros Benitez, Santiago Sastre, Luis Sobrevia, Garth L. Nicolson
Summary: Inwardly rectifying potassium (Kir) channels are important for maintaining membrane potential and potassium homeostasis. These channels have various subtypes and can be regulated by molecules found in nutrients, such as phosphoinositols, polyamines, and Mg2+. Changes in Kir channels can affect metabolism and the ability to absorb nutrients and electrolytes. The study of nutrigenomics of ion channels is crucial for understanding how diet and nutrients can impact ion channel function, expression, and lead to pathological conditions that affect diet and electrolyte intake.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Pharmacology & Pharmacy
Xiao-Yu Liu, Ling-Ling Qian, Ru-Xing Wang
Summary: This review summarizes the role of hydrogen sulfide (H2S) in the regulation of vascular tone, specifically through its interaction with different vascular potassium channels. Studies have shown that H2S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Monika Richter-Laskowska, Paulina Trybek, Domenico Vittorio Delfino, Agata Wawrzkiewicz-Jalowiecka
Summary: Potassium channels are integral proteins responsible for the transport of K+ ions through biological membranes. They are important drug targets due to their physiological roles in membrane potential regulation and cell signaling. Flavonoids, a group of biologically active substances found in plants, have been shown to modulate potassium channels and exert beneficial effects on human health. This article presents the current knowledge on the modulation of potassium channels by flavonoids and discusses the potential implications of these changes. It also suggests future research directions in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Kenji Hashimoto, Mateusz Koselski, Shoko Tsuboyama, Halina Dziubinska, Kazimierz Trebacz, Kazuyuki Kuchitsu
Summary: The two-pore channel (TPC) family is widely conserved and plays an important role in eukaryotes. Vascular plants have a single TPC gene encoding a slow vacuolar (SV) channel, while the liverwort Marchantia polymorpha possesses three TPC homologs, including a unique type 2 TPC. Phylogenetic analysis suggests the emergence of type 2 TPC before land colonization and its loss in vascular plants. Knockout mutants of TPC genes were generated and functional analyses showed that type 1 TPC is responsible for SV channel activity in plants.
PLANT AND CELL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Willy Carrasquel-Ursulaez, Ignacio Segura, Ignacio Diaz-Franulic, Felipe Echeverria, Yenisleidy Lorenzo-Ceballos, Nicolas Espinoza, Maximiliano Rojas, Jose Antonio Garate, Eduardo Perozo, Osvaldo Alvarez, Fernando D. Gonzalez-Nilo, Ramon Latorre
Summary: This study demonstrates that two arginines in the transmembrane segment S4 function as the gating charges of BK channels, and the energy landscape of gating particles is tuned by a network of salt bridges in the voltage sensor domain (VSD). Unlike Kv channels, the charge movement in BK seems limited to a small displacement of the guanidinium moieties of R210 and R213.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Ariadna Delgado-Bermudez, Yentel Mateo-Otero, Marc Llavanera, Sergi Bonet, Marc Yeste, Elisabeth Pinart
Summary: General blockade of potassium channels and specific blockade of SLO1 channels did not result in alterations in sperm quality after thawing compared to control samples. In contrast, blocking HVCN1 channels with 2-GBI led to a significant decrease in post-thaw sperm quality compared to the control, despite lower intracellular O-2(-) and H2O2 levels in 2-GBI blocked samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Anu Tyagi, Tofayel Ahmed, Shi Jian, Saumya Bajaj, Seow Theng Ong, Stephanie Shee Min Goay, Yue Zhao, Igor Vorobyov, Changlin Tian, K. George Chandy, Shashi Bhushan
Summary: This study reports two structures of the human voltage-gated potassium channel Kv1.3 – apo-Kv1.3 and dalazatide-Kv1.3. Both structures are in an activated state and show remarkable rearrangements in the selectivity filter. In apo-Kv1.3, the aromatic residue Y447 adopts a unique position diverging from other K+ channels, while in dalazatide-Kv1.3, binding of dalazatide narrows the selectivity filter and stabilizes Y447 in a position similar to other K+ channels. These structural changes play a crucial role in Kv1.3's transition into the drug-blocked state.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Alice Mett, Izhar Karbat, Michael Tsoory, Shachar Fine, Shachar Iwanir, Eitan Reuveny
Summary: The GIRK1 subunit plays a crucial role in neuronal processes such as spatial learning and memory, locomotion, and depotentiation following LTP, as demonstrated through studies on YFP-GIRK1 and GIRK1-null mice.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Pharmacology & Pharmacy
Chiara Capitani, Ginevra Chioccioli Altadonna, Michele Santillo, Elena Lastraioli
Summary: Despite improvements in treatment, lung cancer continues to be a major global health problem. Adenocarcinoma is the most common subtype, while Small Cell Lung Cancer is the most challenging and difficult to treat. The standard care for these patients involves surgery, radiation therapy, and chemotherapy. The search for novel biomarkers that can aid in diagnosis and therapy is crucial.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biology
Yu Lei, Yue Meng, Xinqi Guo, Ke Ning, Yixin Bian, Lanlan Li, Zhenduo Hu, Anastasia A. Anashkina, Qinghua Jiang, Yucui Dong, Xiao Zhu
Summary: Structural variation (SV) is an important part of biological genetic diversity, and efficient and accurate simulation and identification are crucial. Computer simulation of genomic data has gained attention for its intuitive and convenient advantages. Various high-quality methods and genomic visualization tools have been developed for SV identification and data observation. This study provides a comprehensive understanding of the impact of SV in the context of sequencing technology development.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Bojjibabu Chidipi, Mengmeng Chang, Meng Cui, Obada Abou-Assali, Michelle Reiser, Sergii Pshenychnyi, Diomedes E. Logothetis, Michael N. Teng, Sami F. Noujaim
Summary: We engineered and produced a peptibody that can block the acetylcholine-activated inwardly rectifying potassium current (I-KACh). The peptibody was generated by fusing a biologically active peptide with the fragment crystallizable (Fc) region of human immunoglobulin G (IgG). Our study showed that the peptibody is highly potent and can effectively block I-KACh in both cells and mice, potentially providing new strategies for ion channel modulation and antiarrhythmic therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Donald Iain MacDonald, Ana P. Luiz, Federico Iseppon, Queensta Millet, Edward C. Emery, John N. Wood
Summary: Neuropathic pain leads to innocuous cooling being perceived as excruciating pain, yet the cell and molecular basis of this cold allodynia remains poorly understood. Research has found that in neuropathic pain states, normally silent large diameter cold-sensing neurons become sensitive to cooling, with many of them responding to noxious mechanical stimuli.
Review
Pharmacology & Pharmacy
Ksenia S. Kudryashova, Oksana V. Nekrasova, Mikhail P. Kirpichnikov, Alexey V. Feofanov
Summary: This review discusses the construction of chimeric potassium channels KcsA-Kv1, their applications in studying interactions of pore blockers, and their role in determining molecular basis for high affinity and selectivity of binding of peptide blockers to Kv1 channels.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Oncology
Martina Chirra, Hannah S. Newton, Vaibhavkumar S. Gawali, Trisha M. Wise-Draper, Ameet A. Chimote, Laura Conforti
Summary: Ion channels play a crucial role in regulating T cell function, and the tumor microenvironment can suppress the antitumor capabilities of T cells. Understanding the effects of the tumor microenvironment on ion channels in T cells can lead to the development of more effective immunotherapies.
Article
Multidisciplinary Sciences
Deniz Ozberk, Alison Haywood, Heidi G. Sutherland, Chieh Yu, Cassie L. Albury, Mathew Zunk, Rani George, Phillip Good, Lyn R. Griffiths, Janet Hardy, Larisa M. Haupt
Summary: Opioids are commonly used to manage pain in advanced cancer patients, but the individual response to this therapy varies. This study examined the association between KCNJ6 gene and methadone response in advanced cancer pain management. The results did not show any associations between KCNJ6 gene and methadone dose or pain score, consistent with previous studies in patients receiving opioids for pain in advanced cancer.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
F. C. O. Macedo, H. Dziubinska, K. Trebacz, R. F. Oliveira, R. A. Moral
ACTA PHYSIOLOGIAE PLANTARUM
(2015)
Article
Plant Sciences
Mateusz Koselski, Kazimierz Trebacz, Halina Dziubinska
Article
Plant Sciences
Maria Stolarz, Halina Dziubinska
FRONTIERS IN PLANT SCIENCE
(2017)
Editorial Material
Plant Sciences
Simon Gilroy, Kazimierz Trebacz, Vicenta Salvador-Recatala
FRONTIERS IN PLANT SCIENCE
(2018)
Article
Plant Sciences
Mateusz Koselski, Piotr Wasko, Kamila Kupisz, Kazimierz Trebacz
PHYSIOLOGIA PLANTARUM
(2019)
Article
Plant Sciences
Mateusz Koselski, Halina Dziubinska, Kazimierz Trebacz, Apolonia Sieprawska, Maria Filek
JOURNAL OF PLANT GROWTH REGULATION
(2019)
Article
Plant Sciences
Mateusz Koselski, Kazimierz Trebacz, Halina Dziubinska
ACTA PHYSIOLOGIAE PLANTARUM
(2019)
Article
Plant Sciences
Mateusz Koselski, Sebastian N. W. Hoernstein, Piotr Wasko, Ralf Reski, Kazimierz Trebacz
Summary: Electrical and calcium signals in plants, together with reactive oxygen species (ROS) waves, participate in cell-to-cell signaling, conveying information about different stimuli. In this study, the external application of hydrogen peroxide (H2O2) was found to evoke electrical signals that transmit instantly through the plant, and these signals were calcium-dependent. The measurements also showed the slow propagation and decrement of calcium signals. The study provides insights into the importance of these signals in conveying information about the presence of ROS in plant cells.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Physiology
M. Koselski, A. Olszewska, A. Hordyjewska, T. Malecka-Massalska, K. Trebacz
PHYSIOLOGICAL RESEARCH
(2017)
Article
Plant Sciences
Maria Stolarz, Halina Dziubinska
ACTA PHYSIOLOGIAE PLANTARUM
(2017)
Article
Plant Sciences
Kamila Kupisz, Halina Dziubinska, Kazimierz Trebacz
ACTA PHYSIOLOGIAE PLANTARUM
(2017)