Article
Pharmacology & Pharmacy
Mario Saletti, Marco Paolino, Lavinia Ballerini, Germano Giuliani, Gemma Leone, Stefania Lamponi, Marco Andreassi, Claudia Bonechi, Alessandro Donati, Daniele Piovani, Alberto Giacometti Schieroni, Agnese Magnani, Andrea Cappelli
Summary: An easy and viable crosslinking procedure using click-chemistry was developed for hyaluronic acid. The resulting crosslinked materials showed no cytotoxic effects, tunable water affinity, and rheological properties, suggesting potential applications in different biomedical fields.
Article
Plant Sciences
Jianchao Yan, Jiandong Zhu, Jun Zhou, Chenghua Xing, Hongming Song, Kun Wu, Miaozhen Cai
Summary: The components and structure of the cell wall play a crucial role in aluminum toxicity and tolerance in plants. This study investigated the effects of Brefeldin A (BFA) and nitric oxide (NO) on cell wall assembly and function in response to aluminum. The results showed that BFA inhibited cell wall biosynthesis and made the root cell wall lose its ability to resist aluminum, while NO modified the cell wall composition and functional groups. These findings provide important insights into the mechanisms underlying aluminum tolerance in rice.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Wenjie Wang, Wen-Can Huang, Jie Zheng, Changhu Xue, Xiangzhao Mao
Summary: In this study, a series of dialdehyde derivatives of polysaccharides (DADPs) were prepared by oxidizing polysaccharides, and their biocompatibility and cross-linking properties were tested using chitosan as a model macromolecule. The results showed that the DADPs exhibited outstanding cross-linking and gelation properties comparable to glutaraldehyde (GA) and genipin (GP), and they also demonstrated excellent cytocompatibility and hemocompatibility with different concentrations.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Xiao Ling, Jiajia Zhang, Jianwen Teng, Li Huang, Ning Xia
Summary: This study investigated the interaction between rice proteins and phenolic acid in the gastrointestinal environment. The results showed that rice protein can stabilize the structure of phenolic acid, preventing its degradation in oral fluid and gastrointestinal fluids. The rice protein-phenolic acid complex degraded and released the phenolic acid during digestion, while maintaining its antioxidant function and not affecting its permeability in the digestive tract.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2023)
Review
Agriculture, Dairy & Animal Science
Yan-Lu Wang, Wei-Kang Wang, Qi-Chao Wu, Hong-Jian Yang
Summary: This review summarizes the possible relationships between ester and/or ether-linked ferulic acid (FA) and fiber digestion in ruminant animals. Rumen microbes can break down the ester linkages within plant cell walls and improve cell wall digestibility. Released FA can have antioxidant effects on host animals.
Article
Food Science & Technology
Luciana Ribeiro da Silva Lima, Millena Cristina Barros Santos, Carolina Thomaz dos Santos D'Almeida, Luiz Claudio Cameron, Luiz Carlos Gutkoski, Mariana Simoes Larraz Ferreira
Summary: This study characterized the phenolic profile of whole wheat flour from different genotypes and technological qualities. Thirty-eight phenolic compounds were tentatively identified, mainly belonging to the class of bound hydroxycinnamic acids. The use of omics data and multivariate statistical analyses successfully differentiated the phenolic profile of the whole wheat flour samples.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Food Science & Technology
Siyang Liu, Chuyang Wang, Jinying Gou, Yan Dong, Wenfei Tian, Luping Fu, Yonggui Xiao, Xumei Luo, Zhonghu He, Xianchun Xia, Shuanghe Cao
Summary: This study conducted a genome-wide association study to identify genetic loci controlling ferulic acid content in wheat grains. Eight major loci were discovered, each explaining approximately 10% of the phenotypic variances. The favorable alleles of these loci have significant accumulative effects on ferulic acid content. Additionally, two SNPs closely associated with ferulic acid content were successfully converted to flexible kompetitive allele-specific PCR (KASP) markers for marker-assisted selection in breeding.
JOURNAL OF CEREAL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Jonas Kost, Alexander Bleiziffer, Dennis Rusitov, Juergen Ruehe
Summary: This study focuses on the thermal activation of surface-attached polymer networks under mild conditions, using a novel cross-linker based on a diazo phenyl ester group. The system, which enables the rapid complete cross-linking of films with simultaneous surface attachment to organic materials via CHic, only requires activation below 100 degrees C and has a long shelf life at room temperature. It has potential applications in coatings and complex geometries.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Yang Zhao, Yanjiang Li, Xu Peng, Xiaoshuang Yu, Can Cheng, Xixun Yu
Summary: The study found that oxidized hyaluronic acid (AHA) showed lower cytotoxicity and good crosslinking effect as an alternative crosslinking reagent to glutaraldehyde for fixing acellular bovine pericardium (ABP), making it suitable for abdominal wall repair. Additionally, 2.0% AHA-fixed ABP demonstrated optimal mechanical properties, thermal stability, cytocompatibility, and anti-calcification ability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Mingqin Li, Salwa Karboune, Lan Liu, Kelly Light, Lamia L'Hocine, Allaoua Achouri, Melanie Pitre, Cesar Mateo
Summary: The efficiency of laccase-catalyzed protein cross-linking can be influenced by substrate protein structure and competing reactions. In this study, chemical grafting of ferulic acid on protein surface was used to modulate cross-linking, resulting in different levels of cross-linked products, which were further evaluated for their effects on the structural and functional properties of the proteins.
Article
Plant Sciences
Amanda Fanelli, David M. Rancour, Michael Sullivan, Steven D. Karlen, John Ralph, Diego Mauricio Riano-Pachon, Renato Vicentini, Tatiane da Franca Silva, Andre Ferraz, Ronald D. Hatfield, Elisson Romanel
Summary: The study identified a sugarcane gene (ScAT10) that increases pCA content and reduces FA content in maize, leading to a significant increase in the pCA/FA ratio.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Erika Sabella, Andrea Luvisi, Alessandra Genga, Luigi De Bellis, Alessio Aprile
Summary: The research revealed that the response of cadmium accumulation in durum wheat roots involves various genes and molecular mechanisms, including the expression of specific transcription factors and peroxidase genes. The up-regulation of the transporter protein HMT-1 and peroxidase genes in the low-Cd genotype suggests active elimination of cadmium presence. The study further hypothesizes that certain aquaporins may enhance the translocation of cadmium from roots to shoots.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Lulu Zhu, Xin Qi, Jing Bai, Xiao Sun, Hu Hou
Summary: This study found that crosslinking treatment with celery and chlorogenic acid can improve the stability and hardness of ready-to-eat sea cucumbers. The treatment also causes structural changes in sea cucumbers and inhibits the breakage of peptide bonds in collagen, leading to an overall improvement in the quality of sea cucumbers.
Article
Agriculture, Dairy & Animal Science
D. O. Sousa, M. Murphy, R. Hatfield, E. Nadeau
Summary: This study evaluated the impact of harvest date and forage species on hydroxycinnamic acid concentrations in silage and dairy cow performance. Results showed that late harvesting increased fiber components in timothy and hydroxycinnamic acid concentrations were mainly affected by forage species, ultimately affecting milk production.
JOURNAL OF DAIRY SCIENCE
(2021)
Review
Agronomy
Marcia Maria de O. Buanafina, Phillip Morris
Summary: This article summarizes the evolving concepts and scientific findings on cell wall feruloylation and ferulate oxidative coupling processes in grasses. It also explores the effects of these processes on cell wall properties, plant responses to stress, and tissue degradability. Different strategies for genetically modifying cell wall feruloylation are discussed, with a focus on the heterologous expression of cell wall ferulic acid esterase. The article highlights emerging feruloyl transferase candidate genes involved in ferulate incorporation into grass arabinoxylans.
Article
Plant Sciences
Monica De Caroli, Elisa Manno, Gabriella Piro, Marcello S. Lenucci
Summary: The study compares the secretion patterns of three members of the Arabidopsis thaliana XTH family and reveals that XTH11 and XTH33 use a conventional protein secretion pathway to reach the cell wall and plasma membrane, while XTH29 follows an unconventional protein secretion pathway towards the apoplast. The presence of a 45-amino acid extraterminal region is crucial for the correct cell wall targeting of XTH29. Furthermore, XTH29 is significantly upregulated under drought and heat stress compared to XTH11 and XTH33, indicating different involvement of these XTHs in cell wall remodeling under abiotic stress.
Article
Biochemistry & Molecular Biology
Monica De Caroli, Fabrizio Barozzi, Luciana Renna, Gabriella Piro, Gian-Pietro Di Sansebastiano
Summary: Plants rely on both actin and microtubule cytoskeletons to fine-tune sorting and spatial targeting of membranes during cell growth and stress adaptation. Recent studies have focused on the relationship between the trans-Golgi network/early endosome (TGN/EE) and cytoskeletons, as well as the endoplasmic reticulum (ER) export mechanisms. These studies reveal the crucial role of cytoskeleton in regulating plant endomembrane traffic.
Article
Microbiology
Mirco Vacca, Giuseppe Celano, Marcello Salvatore Lenucci, Sergio Fontana, Flavia Maria la Forgia, Fabio Minervini, Aurelia Scarano, Angelo Santino, Giuseppe Dalfino, Loreto Gesualdo, Maria De Angelis
Summary: The study aimed to develop an innovative synbiotic formulation for reducing dysbiosis and uremic toxins in chronic kidney disease (CKD) patients. Among 25 probiotic strains tested, two strains were selected based on their growth with antioxidants and prebiotics from different vegetable sources. The final synbiotic formulation, NatuREN G, showed positive effects on modifying intestinal bacteria and metabolites in CKD fecal samples.
Article
Biochemistry & Molecular Biology
Andrea Ragusa, Pietrina Romano, Marcello Salvatore Lenucci, Emanuela Civino, Daniele Vergara, Elena Pitotti, Cosimo Neglia, Alessandro Distante, Giampiero Diego Romano, Nicola Di Renzo, Giammarco Surico, Prisco Piscitelli, Michele Maffia
Summary: This observational study conducted on saliva glycoproteins found differential glycosylation patterns among subjects with breast or lung cancer and healthy volunteers, indicating the potential for a reliable and minimally invasive diagnostic protocol to discriminate between healthy and pathological subjects.
Article
Plant Sciences
Anna Montefusco, Miriana Durante, Danilo Migoni, Monica De Caroli, Riadh Ilahy, Zoltan Pek, Lajos Helyes, Francesco Paolo Fanizzi, Giovanni Mita, Gabriella Piro, Marcello Salvatore Lenucci
Summary: This study systematically characterized different fruit parts from four Israeli pomegranate varieties grown simultaneously in the same orchard, revealing significant genotype-dependent variability. The results showed that pomegranate kernels and peels are rich sources of punicic acid and phenols, but their levels' variability emphasizes the need for further research to better exploit their agro-industrial potential.
Article
Biochemistry & Molecular Biology
Marcello Salvatore Lenucci, Riccardo Tornese, Giovanni Mita, Miriana Durante
Summary: This study aims to describe and compare the distribution of bioactive compounds, fatty acids profiles, and antioxidant activities in different fruit fractions of two mango cultivars. Our results provide valuable information on the distribution of nutraceuticals in different parts of mango fruit and highlight the potential value of peels and kernels as sources of novel ingredients. The study also emphasizes the importance of exploring green, novel biorefinery technologies to recover profitable byproducts from mango processing.
Article
Biochemistry & Molecular Biology
Caterina Di Sano, Valentina Lazzara, Miriana Durante, Claudia D'Anna, Angela Bonura, Paola Dino, Carina Gabriela Uasuf, Elisabetta Pace, Marcello Salvatore Lenucci, Andreina Bruno
Summary: Carotenoids may have different effects on cancer. The safety of carotenoid supplements was evaluated in human lung cancer cells. The study found that different oleoresins containing lycopene had varying effects on the cells, with oleoresin containing the highest lycopene concentration increasing cell apoptosis and intracellular stress while decreasing cell proliferation.
Article
Plant Sciences
Angelo De Paolis, Monica De Caroli, Makarena Rojas, Lorenzo Maria Curci, Gabriella Piro, Gian-Pietro Di Sansebastiano
Summary: In this study, the gene homologue of DvNip1 was cloned and its expression profile in roots and shoots under different arsenic stress conditions was characterized. Arsenic stress influences the expression level of DvNip1.1, and the proportion of gene expression can be used as a potential marker to predict arsenic-resistant lines of Dittrichia viscosa plants.
Article
Biology
Monica De Caroli, Patrizia Rampino, Gabriele Pecatelli, Chiara Roberta Girelli, Francesco Paolo Fanizzi, Gabriella Piro, Marcello S. Lenucci
Summary: The study focused on analyzing the effects of overexpressing primary CesA genes in transgenic tobacco plants on cellulose biosynthesis and biomass production. The results showed significant increases in plant size, flower and seed production, and advanced flowering time. This highlights the potentiality of overexpressing primary CesAs in tobacco for enhancing cellulose synthesis and biomass production.
Article
Biology
Monica De Caroli, Patrizia Rampino, Lorenzo M. Curci, Gabriele Pecatelli, Sara Carrozzo, Gabriella Piro
Summary: Climate factors like drought and high temperatures have a significant impact on crop productivity, so it is important to identify plant varieties with stress resistance characteristics and morphological or molecular traits associated with drought tolerance. In this study, six varieties of Cichorium intybus L. were investigated for their response to drought stress, and the Selvatica and Zuccherina di Trieste varieties showed better tolerance to drought stress and potential markers for drought tolerance were identified.
Article
Horticulture
Amani Romdhane, Anissa Riahi, Gabriella Piro, Marcello Salvatore Lenucci, Chafik Hdider
Summary: This research evaluated a tomato germplasm line (OSTGL) under organic conditions and compared it with the variety 'Rio Grande' frequently grown organically in Tunisia. The OSTGL line showed higher yield and better nutritional characteristics, proving to be an effective sustainable variety under an organic management system.
Article
Environmental Studies
Teodoro Semeraro, Roberta Aretano, Amilcare Barca, Alessandro Pomes, Cecilia Del Giudice, Elisa Gatto, Marcello Lenucci, Riccardo Buccolieri, Rohinton Emmanuel, Zhi Gao, Alessandra Scognamiglio