Article
Biotechnology & Applied Microbiology
Qiannan Zhao, Fen Jiang, Hui Zhuang, Yanfeng Chu, Fang Zhang, Chenghong Wang
Summary: miR-124-3p inhibits HCC proliferation and epithelial-mesenchymal transition (EMT) by targeting ARRDC1.
Article
Genetics & Heredity
Masoumeh Hajizadeh, Farnaz Hajizadeh, Sevil Ghaffarei, Mohammad Amin Doustvandi, Khadijeh Hajizadeh, Seyyed Mohammad Yaghoubi, Fateme Mohammadnejad, Nadia Allahyarzadeh Khiabani, Pegah Mousavi, Behzad Baradaran
Summary: This review summarizes the role and potential efficacy of miRNAs in promoting and inhibiting cell proliferation and apoptosis in HCC, as well as the role of miRNAs in therapy resistance in HCC.
Article
Gastroenterology & Hepatology
Bin Sun, Weidan Ji, Chunying Liu, Xuejing Lin, Lei Chen, Haihua Qian, Changqing Su
Summary: miR-2392 is significantly down-regulated in HCC and functions as a tumor suppressor by targeting JAG2 to inhibit proliferation, clonogenicity, mobility, spheroid formation, and maintenance of CSC-like characteristics in HCC cells. CTCs from HCC patients with lower serum miR-2392 levels exhibit stronger spheroid formation ability, and a negative correlation between miR-2392 levels in serum and the number of CTC spheroids has been observed. JAG2 is highly expressed in HCC and is associated with poor prognosis and patient survival.
LIVER INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Kei Takuma, Shintaro Fujihara, Koji Fujita, Hisakazu Iwama, Mai Nakahara, Kyoko Oura, Tomoko Tadokoro, Shima Mimura, Joji Tani, Tingting Shi, Asahiro Morishita, Hideki Kobara, Takashi Himoto, Tsutomu Masaki
Summary: This study investigates the antitumor mechanism of regorafenib on hepatocellular carcinoma (HCC) and the impact on microRNA (miRNA) expression. The results suggest that regorafenib inhibits cell proliferation and tumor growth in HCC by altering the cell cycle and miRNA expression, particularly downregulating cyclin D1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen, Shuying Chen
Summary: Exosomal microRNAs play a crucial role in hepatocellular carcinoma, holding significant value in the early diagnosis and treatment of this disease.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Sharad Khare, Tripti Khare, Raghu Ramanathan, Jamal A. Ibdah
Summary: This review discusses the role and involvement of microRNAs (miRs) in the heterogeneity and metastasis of hepatocellular carcinoma, with a special emphasis on their potential as diagnostic and prognostic tools in the risk prediction, early detection, and treatment of hepatocellular carcinoma.
Article
Biotechnology & Applied Microbiology
Zhiqing Cheng, Limei Gong, Qinghe Cai
Summary: This study found that LINC00978 is upregulated in HCC and is associated with poor prognosis. Silencing LINC00978 can inhibit the growth and metastasis of HCC cells. Mechanistically, LINC00978 functions as a sponge for miR-125b-5p and regulates the expression of SOX12, promoting liver cancer migration, invasion, and proliferation.
Article
Oncology
Xuesong Deng, Jun Cheng, Naiyang Zhan, Jianwei Chen, Yongqiang Zhan, Yong Ni, Caixian Liao
Summary: This study found that TONSL-AS1 expression is downregulated in hepatocellular carcinoma tissues, associated with lower survival rates. There is an interaction between miR-135a and TONSL-AS1, where overexpression of miR-135a decreases TONSL-AS1 expression. Overexpression of TONSL-AS1 inhibits HCC cell proliferation, while overexpression of miR-135a promotes cell proliferation.
Article
Biochemistry & Molecular Biology
Linfeng Mao, Weijie Yuan, Kaimei Cai, Chen Lai, Changhao Huang, Yi Xu, Shangwei Zhong, Chen Yang, Ran Wang, Pengwei Zeng, Heyuan Huang, Zhikang Chen, Zihua Chen
Summary: EphA2, YES1, and ANXA2 form a signaling axis that promotes gastric cancer invasion and metastasis. Overexpression of YES1 increases invasion and migration of gastric cancer cells, while knockdown of ANXA2 decreases these processes.
Article
Gastroenterology & Hepatology
Junfeng Wang, Yongchun Wang, Yifan Chu, Zhixiong Li, Xingjuan Yu, Zhijie Huang, Jing Xu, Limin Zheng
Summary: Tumor-infiltrating macrophages in human hepatocellular carcinoma exhibit higher proliferative capacity, less differentiation, and are induced by tumor cell-derived adenosine and autocrine granulocyte-macrophage colony-stimulating factor (GM-CSF). Local macrophage proliferation is an important mechanism for macrophage accumulation in HCC tissues and selective modulation at the source may offer a novel strategy for cancer therapy.
JOURNAL OF HEPATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Laura Gramantieri, Francesca Fornari, Catia Giovannini, Davide Trere
Summary: miRNAs in HCC play a bidirectional role in both immune-related pathways and oncogenic pathways. Understanding their function can help identify patient subgroups and design personalized treatment strategies.
Article
Medicine, Research & Experimental
Wei Chen, Li Huang, Junhua Liang, Yingjian Ye, Shan He, Junli Niu
Summary: The study revealed that exosomal miR-378b derived from HepG2 cells enhances HCC cell progression and angiogenesis, possibly linked to TGFBR3. Experimental results indicated that up-regulation of miR-378b enhances these effects, while downregulation has a weakening effect.
Article
Obstetrics & Gynecology
Kentaro Kai, Niraj R. Joshi, Gregory W. Burns, Samantha M. Hrbek, Erin L. Vegter, Maria Ariadna Ochoa-Bernal, Yong Song, Genna E. Moldovan, Lorenzo F. Sempere, Eduardo H. Miyadahira, Paulo C. Serafini, Asgerally T. Fazleabas
Summary: This study explores the role of miR-210 and its targets, IGFBP3 and COL8A1, in the growth and development of endometriosis. It was found that miR-210 expression was decreased in ectopic lesions, while IGFBP3 and COL8A1 expression was increased. MiR-210 overexpression suppressed IGFBP3 expression and attenuated cell proliferation and migration.
REPRODUCTIVE SCIENCES
(2023)
Review
Oncology
Jose D. Debes, Pablo A. Romagnoli, Jhon Prieto, Marco Arrese, Angelo Z. Mattos, Andre Boonstra
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. Late diagnosis and limited treatment options contribute to the low survival rate of patients with HCC. Currently, combining ultrasound with the biomarker AFP is a commonly used screening method, but its clinical utility and operator-dependence are controversial.
Article
Cell Biology
Jingwen Yang, Weiwei Dong, He Zhang, Huixia Zhao, Zhiyan Zeng, Fengyun Zhang, Qiuwen Li, Xiaohong Duan, Yanyan Hu, Wenhua Xiao
Summary: This study revealed that the exosomal microRNA panel has high accuracy in diagnosing HCC and has important clinical significance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
ZiJie Lim, Nur Khairiah Binte Mohd-Ismail, Evelyn Png, Ching Wooen Sze, Qifeng Lin, Wanjin Hong, Seng Gee Lim, Yee-Joo Tan, Jayantha Gunaratne
Summary: This study investigated the molecular signaling events during early phases of HBV infection by profiling the phosphoproteome of infected cells. The results showed that HBV infection significantly altered the host phosphoproteome and its associated proteins, including kinases. Computational analysis revealed dysregulation of immune response, cell cycle, and RNA processing pathways during HBV infection. Inhibition of CLKs was found to reduce HBV infection. These findings provide potential targets for developing novel therapeutic strategies for HBV treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Gastroenterology & Hepatology
Nahum Mendez-Sanchez, Elisabetta Bugianesi, Robert G. Gish, Frank Lammert, Herbert Tilg, Mindie H. Nguyen, Shiv K. Sarin, Nuria Fabrellas, Shira Zelber-Sagi, Jian-Gao Fan, Gamal Shiha, Giovanni Targher, Ming-Hua Zheng, Wah-Kheong Chan, Shlomo Vinker, Takumi Kawaguchi, Laurent Castera, Yusuf Yilmaz, Marko Korenjak, C. Wendy Spearman, Mehmet Ungan, Melissa Palmer, Mortada El-Shabrawi, Hans-Juergen Gruss, Jean-Francois Dufour, Anil Dhawan, Heiner Wedemeyer, Jacob George, Luca Valenti, Yasser Fouad, Manuel Romero-Gomez, Mohammed Eslam
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sanchit Sharma, Samagra Agarwal, Anoop Saraya, Ashok Choudhury, Mamun Al Mahtab, Mohd Shahinul Alam, Sanjiv Saigal, Dong Joon Kim, C. E. Eapen, Ashish Goel, Qin Ning, Harshad Devarbhavi, Virendra Singh, Akash Shukla, Saeed Hamid, Jinhua Hu, Soek-Siam Tan, Anil Arora, Manoj Kumar Sahu, Mohd Rela, Dinesh Jothimani, P. N. Rao, Anand Kulkarni, Hashmik Ghaznian, Guan Huei Lee, Duan Zhongping, Ajit Sood, Omesh Goyal, Laurentius A. Lesmana, Rinaldi C. Lesmana, Sombat Treeprasertsuk, Nan Yuemin, Samir Shah, Han Tao, V. M. Dayal, Xin Shaojie, Fazal Karim, Zaigham Abbas, Jose D. Sollano, Kemal Fariz Kalista, Ananta Shreshtha, Diana Payawal, Masao Omata, Shiv Kumar Sarin
Summary: This study evaluated the outcomes of acute variceal bleeding (AVB) in patients with acute-on-chronic liver failure (ACLF) and found that patients with AVB had a higher mortality rate.
HEPATOLOGY INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Man-Fung Yuen, Jeong Heo, Hiromitsu Kumada, Fumitaka Suzuki, Yoshiyuki Suzuki, Qing Xie, Jidong Jia, Yoshiyasu Karino, Jinlin Hou, Kazuaki Chayama, Michio Imamura, Judy Y. Lao-Tan, Seng Gee Lim, Yasuhito Tanaka, Wen Xie, Jung-Hwan Yoon, Zhongping Duan, Masayuki Kurosaki, Sung-Jae Park, Madalinee Eternity Labio, Rajneesh Kumar, Young-Oh Kweon, Hyung Joon Yim, Yu Tao, Jennifer Cremer, Robert Elston, Matt Davies, Sharon Baptiste-Brown, Kelong Han, Fiona M. Campbell, Melanie Paff, Dickens Theodore
Summary: This study evaluated the safety and efficacy of GSK3389404, a drug targeting chronic HBV infection. The results showed that GSK3389404 can reduce the production of HBV viral proteins, although no optimal dosing regimen was identified.
JOURNAL OF HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Yong Chuan Tan, Guan Huei Lee, Daniel Q. Huang, Seng Gee Lim
Summary: HDV uses the HBV surface antigen to enter hepatocytes and is associated with accelerated fibrosis progression and increased risk of hepatocellular carcinoma. Current HBV antiviral agents have poor activity against HDV, therefore the search for drugs that can cure both HBV and HDV is needed.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Yao-Chun Hsu, Dae Won Jun, Cheng-Yuan Peng, Ming-Lun Yeh, Huy Trinh, Grace Lai-Hung Wong, Sung Eun Kim, Chien-Hung Chen, Hyunwoo Oh, Chia-Hsin Lin, Lindsey Trinh, Vincent Wai-Sun Wong, Eilleen Yoon, Sang Bong Ahn, Daniel Huang, Yong Kyun Cho, Jae Yoon Jeong, Soung Won Jeong, Hyoung Su Kim, Qing Xie, Li Liu, Mar Riveiro-Barciela, Pei-Chien Tsai, Elena Vargas Accarino, Hidenori Toyoda, Masaru Enomoto, Carmen Preda, Sebastian Marciano, Joseph Hoang, Chung-Feng Huang, Ritsuzo Kozuka, Satoshi Yasuda, Doina Istratescu, Dong-Hyun Lee, Jia-Ying Su, Yen-Tsung Huang, Jee Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Man-Fung Yuen, Adrian Gadano, Ramsey Cheung, Seng Gee Lim, Maria Buti, Ming-Lung Yu, Mindie H. Nguyen
Summary: This study showed that there was no significant difference in the incidence of HBsAg seroclearance between ETV and TDF in patients with CHB, and this rarely occurred with either regimen.
HEPATOLOGY INTERNATIONAL
(2022)
Review
Gastroenterology & Hepatology
Celina Adraneda, Yong Chuan Tan, Ee Jin Yeo, Guan Sen Kew, Atefeh Khakpoor, Seng Gee Lim
Summary: This study systematically evaluated the clinical utility of hepatitis B core-related antigen (HBcrAg) in chronic hepatitis B (CHB) and found that HBcrAg has limited performance and poor correlation with HBsAg loss and antiviral therapy.
JOURNAL OF HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Seng Gee Lim, Thomas F. Baumert, Carolina Boni, Ed Gane, Massimo Levrero, Anna S. Lok, Mala K. Maini, Norah A. Terrault, Fabien Zoulim
Summary: Functional cure of chronic hepatitis B (CHB), achieved through hepatitis B surface antigen (HBsAg) loss after 24 weeks off therapy, is the goal of current treatment. However, the rarity of achieving this cure with current therapy highlights the need for novel approaches. The three categories of treatment include reducing viral replication, reducing antigen load, and immunotherapies. Combination therapy of nucleos(t)ide analogues and immunotherapy shows promise in reducing HBsAg levels and inducing HBsAg loss in some patients, particularly those with low baseline HBsAg levels. Monitoring during therapy using viral and immunological biomarkers is important to predict HBsAg loss and understand its mechanisms.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Seng Gee Lim, Ee Jin Yeo, Celina Adraneda, Yong Chuan Tan
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Man-Fung Yuen, Robert Plesniak, Seng Gee Lim, Keiji Tsuji, Gheorghe Diaconescu, Adrian Gadano, Ju Hyun Kim, Tarik Asselah, Hyung Joon Yim, Jeong Heo, Giuliano Rizzardini, Harry Janssen, Corneliu Petru Popescu, Diana Petrova, Alexander Wong, Nevin Indriz, Cristina Pojoga, Yasuhito Tanaka, Denis Gusev, Ewa Janczewska, Jennifer Cremer, Robert Elston, Tamara Lukic, Lauren Maynard, Stuart Kendrick, Punam Bharania, Fiona Campbell, Melanie Paff, Dickens Theodore
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Cameron Soulette, Lindsey May, Atefeh Khakpoor, Dong Han, Ricardo Ramirez, Narmada Balakrishnan, Nicholas Van Buuren, Ramanuj Dasgupta, Vithika Suri, Li Li, Hongmei Mo, Becket Feierbach, Jeffrey Wallin, Seng Gee Lim
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Yong Chuan Tan, Liang Shen, Htet Htet Toe Wai Khine, Yuh Ling Amy Tay, Celina Adraneda, Jean-Francois Rossignol, Celine Rossignol, Seng Gee Lim
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Yong Chuan Tan, Celina Adraneda, Ee Jin Yeo, Guan Sen Kew, Atefeh Khakpoor, Seng Gee Lim
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Seng Gee Lim, Cristina Pojoga, Harry Janssen, Michio Imamura, Ewa Janczewska, Robert Plesniak, Keiji Tsuji, Corneliu Petru Popescu, Diana Petrova, Adrian Gadano, Alexander Wong, Tarik Asselah, Hyung Joon Yim, Jeong Heo, Man-Fung Yuen, Gheorghe Diaconescu, Giuliano Rizzardini, Jennifer Cremer, Robert Elston, Stuart Kendrick, Geoff Quinn, Fiona Campbell, Melanie Paff, Dickens Theodore
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Seng Gee Lim, Ada Ee Der Teo, Edwin Shih-Yen Chan, Wah Wah Phyo, David Hsing Yu Chen, Carol Anne Hargreaves
JOURNAL OF HEPATOLOGY
(2022)