Review
Oncology
Jane E. Rogers, Kohei Yamashita, Matheus Sewastjanow-Silva, Allison Trail, Rebecca E. Waters, Jaffer Ajani
Summary: Human epidermal growth factor receptor-2 (HER2) is a well-known cancer target with various therapies available. However, the response and effectiveness of HER2-targeted agents differ among different tumor types, including gastric adenocarcinomas (GACs). GACs exhibit heterogeneity in HER2 expression, both within and between tumors, which poses challenges in assessing the efficacy of HER2-targeted agents. The recent approval of trastuzumab deruxtecan, an antibody drug conjugate, for refractory HER2-positive advanced GAC patients shows promise. Ongoing research aims to understand resistance patterns and intra-tumor heterogeneity to improve treatment outcomes. This review discusses the current status of HER2-targeted therapy in GACs and explores new therapies under investigation.
Article
Multidisciplinary Sciences
Thorben Schrumpf, Hans-Michael Behrens, Jochen Haag, Sandra Krueger, Christoph Roecken
Summary: The expression and tumor biological significance of FGFR2 in gastric cancer were independently validated in a non-Asian patient cohort. While FGFR2 expression did not correlate with overall patient survival, a negative correlation was found in diffuse-type gastric cancer, which was associated with lower tumor grade and intestinal phenotype.
Article
Multidisciplinary Sciences
Masakazu Yashiro, Kenji Kuroda, Go Masuda, Tomohisa Okuno, Yuichiro Miki, Yurie Yamamoto, Tomohiro Sera, Atsushi Sugimoto, Shuhei Kushiyama, Sadaaki Nishimura, Shingo Togano, Masaichi Ohira
Summary: FGFR2 has two isoforms, IIIb and IIIc, with unclear clinicopathologic significance in gastric cancer. This study found that 4.9% of gastric tumors overexpressed FGFR2IIIb, and 0.7% overexpressed FGFR2IIIc, with both significantly correlated with lymph node metastasis and clinical stage. FGFR2IIIc overexpression might be an independent prognostic factor for gastric cancer patients.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Guihong Liu, Tao Chen, Zhenyu Ding, Yang Wang, Yuquan Wei, Xiawei Wei
Summary: The FGF-FGFR signaling pathway and the VEGF-VEGFR signaling pathway play important roles in the treatment of tumors, and inhibitors targeting these two pathways can optimize therapeutic effects and expand the antitumor range. In addition, biomarkers should be developed in the future to predict efficacy, and combination with immune checkpoint inhibitors is a promising direction.
CELL PROLIFERATION
(2021)
Article
Medicine, General & Internal
Hyunjin Kim, Sujin Park, So Young Kang, Soomin Ahn, Kyoung-Mee Kim
Summary: The study found that FGFR2 amplification is associated with peritoneal seeding in gastric carcinoma patients and is significantly correlated with high TMB and female patients. Patients with FGFR2 amplification may be potential candidates for targeted therapy.
Article
Medicine, General & Internal
Hongqi Zhang, Gang Xiang, Jiong Li, Sihan He, Yunjia Wang, Ang Deng, Yuxiang Wang, Chaofeng Guo, Xiuyuan Hao
Summary: This study investigated the relationship between congenital scoliosis (CS) and fibroblast growth factor 23 (FGF23). The results showed that CS patients had increased FGF23 mRNA levels in the peripheral blood and decreased bone mineral density. Additionally, FGF23 may contribute to osteopenia in CS patients through the FGFr3/TNAP/OPN pathway.
CHINESE MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Hongqi Zhang, Gang Xiang, Jiong Li, Sihan He, Yunjia Wang, Ang Deng, Yuxiang Wang, Chaofeng Guo
Summary: The study investigates the relationship between congenital scoliosis (CS) and fibroblast growth factor 23 (FGF23). The results show that CS patients have increased peripheral blood FGF23 mRNA levels and decreased bone mineral density, suggesting that FGF23 may contribute to osteopenia in CS patients through the FGFr3/TNAP/OPN pathway.
CHINESE MEDICAL JOURNAL
(2023)
Article
Cell Biology
Xuan Wang, Shuyong Wang, Baolin Guo, Yuxin Su, Zuolong Tan, Mingyang Chang, Jinmei Diao, Yi Zhao, Yunfang Wang
Summary: The study presents a method for establishing and expanding human primary epidermal organoids under a chemically defined condition, which show tolerance to dermatophyte infections caused by Trichophyton Rubrum. This experimental model provides new insights into the pathogenesis of T. rubrum infections and serves as a potential tool for studying and testing antifungal drugs.
CELL DEATH & DISEASE
(2021)
Review
Pharmacology & Pharmacy
Haijun Wang, Jie Yang, Ke Zhang, Jia Liu, Yushan Li, Wei Su, Na Song
Summary: Hepatocellular carcinoma (HCC) is a primary liver cancer with increasing incidence and mortality rates globally. The FGF/FGFR signaling axis has been shown to play an important role in HCC development, and targeted therapies are currently being developed to inhibit this pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Anatomy & Morphology
Marthandam Asokan Shibu, Chih-Yang Huang, Dah-Ching Ding
Summary: This study investigates the potential therapeutic application of human umbilical cord mesenchymal stromal cells (HUCMSCs) in liver diseases. The study finds that HUCMSCs can differentiate into hepatocyte-like cells (HLCs) and efficiently integrate into damaged liver tissue. The differentiation of HUCMSCs into HLCs can be induced by treating them with a hepatic differentiation medium containing hepatocyte growth factor (HGF). This approach provides an alternative protocol for cell-based therapy in liver diseases.
Review
Endocrinology & Metabolism
Giovanni Vitale, Alessia Cozzolino, Pasqualino Malandrino, Roberto Minotta, Giulia Puliani, Davide Saronni, Antongiulio Faggiano, Annamaria Colao
Summary: Neuroendocrine neoplasms are tumors originating from neuroendocrine cells in different organs, with dysregulation of receptor tyrosine kinases playing a crucial role in their development and progression. Research on the role of the fibroblast growth factor receptor system in NENs and the potential of FGFR selective inhibitors shows promising anti-tumor activity in advanced NEN patients, with further studies needed for confirmation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Ran Na, Jin Young Kim, Chang Ho Song, Mikyung Kim, Yen Thi Do, Tam Thuy Lu Vo, Eunsom Choi, Eunyoung Ha, Ji Hae Seo, So-Jin Shin
Summary: This study demonstrated the promising antitumor effects of AZD4547 in ovarian cancer cells, including inhibition of proliferation, induction of apoptosis, suppression of migration and invasion, reduction of stem cell activity and angiogenesis, as well as inhibition of in vivo tumor growth in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Hao Chen, Jiazhou Li, Demao Zhang, Xuedong Zhou, Jing Xie
Summary: The fibroblast growth factor family (FGFs) are cytokines that play crucial roles in growth, development, metabolism, and diseases, with FGF19 showing spatial-temporal gene expression specificity in the skeletal system and influencing bone-related diseases.
Article
Rheumatology
Keishi Etori, Shigeru Tanaka, Jun Tamura, Koto Hattori, Shin-Ichiro Kagami, Junichi Nakamura, Seiji Ohtori, Hiroshi Nakajima
Summary: This study found that FGFR1 marks terminal effector Tph cells in patients with RA, suggesting its important role in the pathogenesis of RA.
Article
Pharmacology & Pharmacy
Leah R. Benington, Gunesh Rajan, Cornelia Locher, Lee Yong Lim
Summary: This study aimed to develop stable formulations of FGF-2 using pharmaceutical excipients to withstand physical stressors encountered in processing and storage. Formulations containing MC and alanine (F5) or MC and HSA (F6) were the most effective in stabilizing FGF-2 against thermal and processing stressors. These stabilized solutions have potential applications in medicinal products or in more advanced forms for wound healing and tissue regeneration.
