Article
Biochemistry & Molecular Biology
Eloisa Aparecida Vilas-Boas, Lisa Nalbach, Emmanuel Ampofo, Camila Ferraz Lucena, Lea Naudet, Fernanda Ortis, Angelo Rafael Carpinelli, Bruce Morgan, Leticia Prates Roma
Summary: Modern lifestyles, lack of physical activity, poor nutrition, and high levels of saturated free fatty acids in obese individuals contribute to the increasing prevalence of obesity and type 2 diabetes. The study suggests that transient NOX2-dependent H2O2 production may be a key factor in early palmitate-induced lipotoxic effects.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Plant Sciences
Lei Liu, Yanchao Sun, Meijing Zhang, Ruixiang Liu, Xiaming Wu, Yanping Chen, Jianhua Yuan
Summary: This study found that BR treatment can increase the kinase activity of ZmBSK1, which in turn induces the production of H2O2. Specifically, ZmBSK1 regulates the gene expressions and activities of NADPH oxidases through phosphorylating ZmCCaMK. Genetic analysis also showed that the ZmBSK1-ZmCCaMK module enhances plant tolerance to oxidative stress induced by H2O2.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Zi-Dan Zhu, Hai-Jing Sun, Jiao Li, Ya-Xin Yuan, Jun-Feng Zhao, Chun-Guang Zhang, Yu-Ling Chen
Summary: Research has shown that RIC7 overexpression negatively regulates ABA-induced stomatal closure and affects H2O2 generation in guard cells, indicating an interdependency between RIC7 and H2O2 in ABA guard-cell signaling.
PLANT SIGNALING & BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Giulia Blandino, Mara Fiorani, Barbara Canonico, Rita De Matteis, Andrea Guidarelli, Mariele Montanari, Gloria Buffi, Lucia Coppo, Elias S. J. Arner, Orazio Cantoni
Summary: Long-term treatment of schizophrenia with clozapine may lead to metabolic disorders, and this study found that clozapine can inhibit adipogenesis and reduce reactive oxygen species produced by NADPH oxidase. Clozapine also suppresses antioxidant responses and promotes mitochondrial superoxide formation, which may be associated with insulin resistance and metabolic syndrome. These cellular events may provide insights into the molecular mechanisms underlying the adverse metabolic effects of clozapine.
Article
Biochemistry & Molecular Biology
Md Ahasanur Rahman, Herman Fennell, Hemayet Ullah
Summary: The scaffold protein receptor for Activated C Kinase1 (RACK1) plays a critical role in regulating various aspects of plant growth and development. Recent studies have shown that RACK1 is involved in reactive oxygen species (ROS) signaling in plants. This study investigated the connection between RACK1 and ROS balance in rice plants by analyzing T-DNA-mediated activation-tagged RACK1B overexpressed (OX) transgenic rice plants. The results showed that overexpression of OsRACK1B led to abnormalities in pollen viability, anther dehiscence, and spikelet morphology, resulting in partial spikelet sterility. The study also found that the elevated ROS levels in the transgenic plants could be attributed to NADPH oxidase. These findings suggest that optimal expression of RACK1 is crucial for fertility in rice plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Cheng Chen, Shijin Wang, Linna Yu, Johannes Mueller, Franco Fortunato, Vanessa Rausch, Sebastian Mueller
Summary: Short-term ethanol exposure induces autophagy in hepatocytes both in vivo and in vitro through the generation of ROS. This suggests that chronic alcohol consumption may suppress autophagy due to the accumulation of misfolded proteins.
Article
Biochemistry & Molecular Biology
Junqing Gong, Lijuan Yao, Chunyang Jiao, Zhujuan Guo, Shuwen Li, Yixin Zuo, Yingbai Shen
Summary: Plants use EVK to regulate stomatal closure, thereby limiting water loss and improving pathogen resistance. EVK induces stomatal closure by increasing guard cell K+ efflux. This study also found that eATP and H2O2 play important roles in EVK-regulated K+ efflux.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biophysics
Shigekuni Hosogi, Yoshinori Marunaka, Eishi Ashihara, Tadaaki Yamada, Ayumi Sumino, Hideo Tanaka, Leonardo Puppulin
Summary: A newly designed nanosensor anchored to the outer cell surface can quantify H2O2 at nanometer distance, providing important information for studying cell signaling. The nanosensor is built upon gold nanoparticles functionalized with a H2O2-sensitive boronate compound and probed using surface enhanced Raman spectroscopy (SERS).
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Plant Sciences
Qin Liu, Ruirui Liu, Yaping Zhou, Wei Wang, Guofan Wu, Ning Yang
Summary: This study investigated the functions and relationship of PLD8, H2S, and H2O2 in osmotic stress-induced stomatal closure. The results showed that the accumulation of H2O2 was essential for inducing stomatal closure under osmotic stress, and PLD delta and LCD acted upstream of H2O2.
JOURNAL OF PLANT PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Leticia Guadalupe Fragoso-Morales, Jose Correa-Basurto, Martha Cecilia Rosales-Hernandez
Summary: Alzheimer's disease is a major human dementia characterized by memory loss associated with oxidative stress in brain cells. Overexpression of NADPH oxidase in AD leads to the production of large amounts of reactive oxygen species, damaging brain cells and vasculature, making it a potential therapeutic target for AD.
Editorial Material
Plant Sciences
Pooja Singh, Vipul Mishra, Durgesh Kumar Tripathi, Francisco J. Corpas, Vijay Pratap Singh
Summary: Reactive oxygen species (ROS) play a crucial role in plant development and stress response. Recent research by Li et al. showed that ROS production is regulated by receptor-like cytoplasmic kinase (RLCK)-mediated phosphorylation of respiratory burst oxidase homolog D (RBOHD), which in turn modulates plant immunity and enhances biotic stress tolerance.
TRENDS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Anthony L. Sylvester, David X. Zhang, Sophia Ran, Natalya S. Zinkevich
Summary: Reactive oxygen species (ROS) play important roles in health and disease, with both beneficial and harmful effects. Different sources of ROS have different roles in various pathologies. NOX1 is associated with hypertension through ROS production, making it a promising therapeutic target. NOX2 and NOX4 produce hydrogen peroxide, influencing cellular processes. Increased ROS production from NOX5 contributes to atherosclerosis.
Review
Plant Sciences
Xiaonan Ma, Ling Bai
Summary: Plant guard cells play a crucial role in regulating stomatal aperture for photosynthesis and transpiration. CO2 serves as an important regulator of stomatal movement, with high levels triggering closure. ROS has been identified as a key component in this regulation, highlighting the complexity of CO2 signaling pathways. Further research is needed to fully understand the molecular mechanisms, particularly related to ROS, involved in these responses.
Article
Plant Sciences
Hai Zhang, Zongtao Yang, Guangyuan Cheng, Tingxu Luo, Kang Zeng, Wendi Jiao, Yingshuan Zhou, Guoqiang Huang, Jisen Zhang, Jingsheng Xu
Summary: This study demonstrates that SCMV infection upregulates the expression of ScRBOHs and the accumulation of H2O2, which inhibits SCMV replication. The interaction between SCMV-6K2 and ScPIP2;4 interferes with the transport of H2O2, highlighting a mechanism adopted by SCMV to counteract host resistance and providing potential molecular targets for engineering sugarcane resistance against SCMV.
Article
Plant Sciences
Ilaria Fraudentali, Chiara Pedalino, Riccardo D'Inca, Paraskevi Tavladoraki, Riccardo Angelini, Alessandra Cona
Summary: Polyamines (PAs) are essential for cell growth and differentiation, and are oxidized by copper amine oxidases (CuAOs) to produce hydrogen peroxide (H2O2) and ammonia. The enzymes AtCuAO beta and RBOHD play crucial roles in the stomatal closure response triggered by leaf and root wounding in plants.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Wanli You, Jinglin Zhang, Xueyin Ru, Feng Xu, Zhengguo Wu, Peng Jin, Yonghua Zheng, Shifeng Cao
Summary: This study investigated the effect of calcium chloride (CaCl2) treatment on GABA accumulation in fresh-cut cantaloupe and the underlying mechanisms. The results showed that CaCl2 treatment increased GABA content and the activities of GAD and SSADH enzymes, while reducing glutamate content and GABA-T activity. Additionally, CaCl2 treatment upregulated the expressions of CmCML11 and CmCAMTA5, as well as several GABA shunt genes, through the transcriptional activation by CmCAMTA5. Furthermore, the interaction between CmCML11 and CmCAMTA5 enhanced the transcriptional activation of GABA shunt genes. Overall, this study reveals that CaCl2 treatment promotes GABA accumulation in fresh-cut cantaloupe through the combined effect of CmCML11 and CmCAMTA5 in regulating the expressions of GABA shunt genes.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Min Wang, Yupeng Wang, Xiaohui Wang, Guangwei Wei, Huiyi Yang, Xi Yang, Tinghai Shen, Huijie Qu, Sheng Fang, Ziming Wu
Summary: This study identified the high nitrogen use efficiency (NUE) black sesame variety 17-156 and analyzed its underlying physiological and molecular mechanisms. The results showed that 17-156 possesses a sophisticated nitrogen metabolizing machinery to uptake and assimilate higher quantities of inorganic nitrogen, simultaneously improving carbon metabolism and growth. Many important genes were up-regulated in 17-156 under high nitrogen condition. Additionally, 38 potential candidate genes were identified for future studies to improve sesame's NUE. These findings provide valuable resources for understanding the regulatory network of nitrogen metabolism and developing sesame cultivars with improved NUE.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
He Dong, Chongmei Xu, Chengtao Zhang, Li Zhang, Yaqin Yao, Suiqi Zhang
Summary: The study found that short cells in maize leaves not only improve leaf mechanical support and photosynthetic performance, enhance drought resistance, but also participate in stomatal regulation.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Na Liu, Wenyan Shang, Mengxin Guan, Jibin Xiao, Guangxiang Tian, Baozhan Ma, Wenjing Shang, Xu Li, Shijia Zhao, Chuang Li, Kun Cheng, Wenming Zheng
Summary: This study cloned the full-length cDNA sequence of TaSPX3 gene in wheat and found that TaSPX3 responds to low phosphorus stress in multiple wheat genotypes. Overexpressing TaSPX3 can alleviate phosphorus deficiency symptoms and promote plant growth in Arabidopsis. The study also revealed the interaction of TaSPX3 with other genes related to the phosphorus starvation signaling pathway.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Kongyuan Wu, Lizhen Wang, Zihan Wu, Ziqing Liu, Zengfei Li, Jun Shen, Shengjie Shi, Hong Liu, Christopher Rensing, Renwei Feng
Summary: Selenium (Se) can reduce uptake and translocation of cadmium (Cd) in plants by regulating root morphology. This study investigated the effects of Se(IV) on root exudates, root morphology, root endogenous hormones, and Cd uptake efficiency in rice under Cd stress. The results showed that Se(IV) significantly reduced Cd concentrations in shoots and roots, and decreased Cd uptake efficiency via root hairs. Se(IV) also affected root morphology, root exudates, and the synthesis of hormones like IAA and JA. However, transcriptome analysis revealed no upregulated differentially expressed genes (DEGs) in IAA synthesis.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Di Wang, Huaifang Zhang, Xuefei Hu, Haizhen Zhang, Shuang Feng, Aimin Zhou
Summary: This study identified a cell number regulator gene called SlCNR8 in willow, which enhances resistance to trace metals in transgenic poplar seedlings. SlCNR8 reduces Cd uptake and accumulation, and can be used as a candidate gene for genetic improvement of phytostabilisation of trace metals.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)