Article
Biochemistry & Molecular Biology
Song Sheng, Xinyu Guo, Changzheng Wu, Yucheng Xiang, Shuhui Duan, Weiqin Yang, Wenrui Li, Fengchun Cao, Laihua Liu
Summary: This study identified 172 DREBs in alfalfa and analyzed their expression and characteristics. It found that some MsDREBs play an important role in the cold-stress response and could be potential targets for improving cold tolerance in crops.
PLANT SIGNALING & BEHAVIOR
(2022)
Article
Horticulture
Lifang Geng, Lin Su, Yuan Wang, Ziwen Geng, Shang Lin, Yichang Zhang, Shuang Yu, Lufeng Fu, Qinghua Liu, Chenxia Cheng, Xinqiang Jiang
Summary: In this study, a novel dehydration response element binding protein RcTINY2 was identified and characterized in rose, which regulates the response to drought and salt stress and may serve as a candidate gene for improving plant tolerance to abiotic stress.
Article
Biochemistry & Molecular Biology
Yufeng Chen, Zhu Li, Tingting Sun, Dongjiao Wang, Zhoutao Wang, Chang Zhang, Youxiong Que, Jinlong Guo, Liping Xu, Yachun Su
Summary: In this study, a novel ScDREB2B-1 gene was identified in sugarcane, which plays a role in drought response by regulating ABA signaling, ROS levels, and stress-related gene expression. The overexpression of this gene improved the drought tolerance of transgenic plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Kai Chen, Wensi Tang, Yongbin Zhou, Jun Chen, Zhaoshi Xu, Rui Ma, Yingshan Dong, Youzhi Ma, Ming Chen
Summary: Soybean, as a main economic crop and a major source of oil and protein, is greatly affected by drought stress. This study explores the value of applying the GmDREB1 gene in improving the drought resistance of soybean. The results show that overexpression of GmDREB1 significantly enhances the drought resistance and yield of transgenic soybean. Mechanism analysis reveals that GmDREB1 regulates the expression of stress-related genes by interacting with ERF-like transcription factors, thus improving the drought resistance of transgenic soybean.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Plant Sciences
Zhensong Li, Xianglin Li, Feng He
Summary: Soil water content only affects the regeneration time of alfalfa, while the content of non-structural carbohydrates (NSCs) is related to the success of regeneration. This study analyzed the dynamic change and allocation of root NSCs under three irrigation frequencies and found that NSCs are the key driver of cold tolerance and regeneration. These findings provide further insight into the mechanism of overwintering and can help improve water management of alfalfa in high latitude areas.
Article
Plant Sciences
Hongyan Hu, Xiaowei Wang, Zhijun Wu, Mo Chen, Tuanyao Chai, Hong Wang
Summary: Plants have evolved complex signaling networks to adapt to adverse environmental conditions. PcDREB2A, a novel DREB transcription factor gene identified from Polygonum cuspidatum, plays a crucial role in plant responses to abiotic stresses. Overexpression of PcDREB2A in Arabidopsis thaliana resulted in increased drought tolerance and improved growth performance.
JOURNAL OF PLANT BIOLOGY
(2022)
Article
Plant Sciences
Jinqiu Yu, Yuying Yuan, Wenkai Zhang, Tingting Song, Xiangyin Hou, Lingzelai Kong, Guowen Cui
Summary: In this study, an NF-YC2 gene was identified in alfalfa and its role in enhancing alkaline adaptation abilities in alfalfa was explored. Transgenic plants with overexpression of MsNF-YC2 exhibited higher levels of antioxidant enzyme activities and proline levels, as well as reduced levels of hydrogen peroxide and superoxide anion. Transcriptomic analysis revealed that MsNF-YC2 overexpression regulated the expression of genes related to plant hormone signal transduction and photosynthesis.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Xiaohan Yang, Yunchen Luo, Huiru Bai, Xin Li, Si Tang, Xiaoqin Liao, Lei Zhang, Qinglin Liu
Summary: In this study, a cold-induced MYB transcription factor, DgMYB2, was found to enhance cold tolerance in chrysanthemum by increasing the activity of glutathione peroxidase and reducing reactive oxygen species accumulation.
HORTICULTURE RESEARCH
(2022)
Article
Plant Sciences
Shumin Wang, Tao Guo, Yixin Shen, Zhen Wang, Junmei Kang, Jiaju Zhang, Fengyan Yi, Qingchuan Yang, Ruicai Long
Summary: MtRAV3, a transcription factor in legumes, plays a crucial role in plant adversity response and growth regulation by enhancing tolerance to various stresses and influencing the expression of adversity-related genes. Overexpression of MtRAV3 in Medicago truncatula resulted in improved stress tolerance, altered expression of key genes, and distinct plant phenotypes.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Agronomy
Hongjia Zhang, Tao Wu, Zhao Li, Kai Huang, Na-Eun Kim, Ziming Ma, Soon-Wook Kwon, Wenzhu Jiang, Xinglin Du
Summary: The GATA-type zinc finger transcription factor OsGATA16 improves cold tolerance in rice at the seedling stage by acting as a positive regulator and repressing cold-related genes. Haplotype analysis revealed a non-synonymous SNP8 (336(G)) associated with cold tolerance, providing new germplasm resources for rice breeding.
Article
Genetics & Heredity
Guangjun Li, Lei Jin, Song Sheng
Summary: This study identified 65 bHLH genes that were significantly upregulated under cold stress in alfalfa. These bHLH genes were classified into six subfamilies and showed relatively diverse expression patterns, suggesting their involvement in a complex cold-responsive regulatory network. Conserved transcription factor binding site (TFBS) distributions were found in the promoter regions of genes with similar expression patterns. Through analysis of transcriptome data in different subspecies of alfalfa, 11 potential cold acclimation genes were identified as candidates for further enhancement of cold tolerance and molecular breeding in alfalfa through genetic engineering.
Article
Biochemistry & Molecular Biology
Huihui Wang, Yanqiu Zhu, Ping Yuan, Shanglin Song, Tianyu Dong, Peilei Chen, Zhikun Duan, Lina Jiang, Longdou Lu, Hongying Duan
Summary: This study demonstrates the tissue-specific expression and differential effects of osmotic stress on DREB2, DREB6, and Wdreb2 in wheat AK58. Promoter methylation plays a role in regulating the expression of Wdreb2 in response to osmotic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Qiguo Sun, Risheng Huang, Haifeng Zhu, Yanmei Sun, Zhenfei Guo
Summary: MtCML42 positively regulates the expression of MtCBF1 and MtCBF4, leading to upregulation of some COR genes, MtGolS1 and MtGolS2, resulting in raffinose accumulation and increased cold tolerance. Additionally, MtCML42 regulates flowering time through sequentially downregulating MtABI5 and upregulating MtFTa1 expression.
Article
Plant Sciences
Chunbo Song, Mengbo Wu, Ying Zhou, Zehao Gong, Weiwei Yu, Yi Zhang, Zhenfeng Yang
Summary: The research identified two cold-responsive NAC transcription factors in bananas that negatively regulate cold tolerance in banana fruits by upregulating the expression of phospholipid degradation genes, forming a positive feedback loop to induce phospholipid degradation and produce phosphatidic acid. Ethylene was found to directly inhibit phospholipid degradation in banana and transgenic tomato fruits.
HORTICULTURE RESEARCH
(2022)
Article
Plant Sciences
Chong Ren, Peige Fan, Shaohua Li, Zhenchang Liang
Summary: This review summarizes recent major advances in physiological and molecular analyses of cold tolerance in grapevine and discusses strategies for improving tolerance to cold stress. Understanding grapevine cold tolerance will facilitate the development of grapevines for adaption to global climate change.
Article
Biochemistry & Molecular Biology
Xiuxiu Xu, Yonggang Zhou, Binqing Fu, Jinghe Zhang, Zhongjun Dong, Xiaoren Zhang, Nan Shen, Rui Sun, Zhigang Tian, Haiming Wei
Article
Oncology
Dongsheng Wang, Binqing Fu, Zhen Peng, Dongliang Yang, Mingfeng Han, Min Li, Yun Yang, Tianjun Yang, Liangye Sun, Wei Li, Wei Shi, Xin Yao, Yan Ma, Fei Xu, Xiaojing Wang, Jun Chen, Daqing Xia, Yubei Sun, Lin Dong, Jumei Wang, Xiaoyu Zhu, Min Zhang, Yonggang Zhou, Aijun Pan, Xiaowen Hu, Xiaodong Mei, Haiming Wei, Xiaoling Xu
Summary: Tocilizumab may be effective in COVID-19 patients by improving hypoxia. This treatment is particularly beneficial in patients with bilateral pulmonary lesions and elevated IL-6 levels.
FRONTIERS OF MEDICINE
(2021)
Editorial Material
Immunology
Jinghe Zhang, Haibo Wu, XiaoHong Yao, Dingyu Zhang, Yonggang Zhou, Binqing Fu, Wei Wang, Heng Li, Zhe Wang, Ziming Hu, Yong Ren, Rui Sun, Zhigang Tian, Xiuwu Bian, Haiming Wei
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Linlin Jin, Zimin Sun, Huilan Liu, Xiaoyu Zhu, Yonggang Zhou, Binqing Fu, Xiaohu Zheng, Kaidi Song, Baolin Tang, Yun Wu, Jiang Zhu, Rui Sun, Zhigang Tian, Haiming Wei
Summary: Unrelated cord blood transplantation is effective for hematopoietic disorders but often leads to pre-engraftment syndrome (PES). GM-CSF produced by cord blood-derived inflammatory monocytes drives PES pathology, and tocilizumab has shown clinical efficacy in limiting pathology in PES patients. This study provides insights into the pathogenesis and treatment of PES, improving nonrelapse mortality outcomes.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Xianghui Du, Huaiping Zhu, Defeng Jiao, Zhigang Nian, Jinghe Zhang, Yonggang Zhou, Xiaohu Zheng, Xianhong Tong, Haiming Wei, Binqing Fu
Summary: This study established three in vitro induction systems to induce human CD49a(+) NK cells, which are phenotypically and functionally similar to decidual NK cells, and can promote fetal growth and improve uterine artery blood flow.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xiuxiu Xu, Xirui Zhao, Ling Chen, Muziying Liu, Ziming Hu, Jieqi Ke, Binqing Fu, Yonggang Zhou, Haiming Wei
Summary: CD158a(+) NK cells increased while CD158b(+) NK cells decreased in the peripheral blood of patients with pre-eclampsia compared to healthy individuals. The change in the frequency of CD158a(+)/CD158b(+) NK cells is related to the increase in blood pressure.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Reproductive Biology
Xiuxiu Xu, Yonggang Zhou, Binqing Fu, Haiming Wei
Summary: During pregnancy, the interaction between maternal decidual tissue and fetal trophoblasts at the maternal-fetal interface is responsible for supplying nutrition to the fetus. Uterine natural killer (uNK) cells, the most abundant immune cells at the interface, play critical roles throughout pregnancy.
BIOLOGY OF REPRODUCTION
(2022)
Article
Hematology
Dongyao Wang, Zimin Sun, Xiaoyu Zhu, Xiaohu Zheng, Yonggang Zhou, Yichen Lu, Peidong Yan, Huiru Wang, Huilan Liu, Jing Jin, Huaiping Zhu, Rui Sun, Yi Wang, Binqing Fu, Zhigang Tian, Haiming Wei
Summary: This study reveals that the dysfunction of bone marrow-derived NK (BMNK) cells in AML patients experiencing relapse after allo-HSCT is associated with increased levels of active TGF-01. TGF-01 suppresses BMNK cell effector function by inhibiting mTORC1 activity, mitochondrial oxidative phosphorylation, proliferation, and cytotoxicity. Blocking TGF-01 signaling improves the antitumor activity of NK cells.
Article
Immunology
Xi Fang, Yonggang Zhou, Siao Chen, Xiuxiu Xu, Jieqi Ke, Ying Zhou, Haiming Wei, Binqing Fu
Summary: NK cells can eliminate intra-cellular bacteria and protect infected cells by synthesizing and transporting lipids to maintain lipid metabolism homeostasis.
Correction
Hematology
Dongyao Wang, Zimin Sun, Xiaoyu Zhu, Xiaohu Zheng, Yonggang Zhou, Yichen Lu, Peidong Yan, Huiru Wang, Huilan Liu, Jing Jin, Huaiping Zhu, Rui Sun, Yi Wang, Binqing Fu, Zhigang Tian, Haiming Wei
Article
Oncology
Yiqing Shen, Xiaohu Zheng, Yeben Qian, Mantian Liu, Zhigang Nian, Quanwei Cui, Yonggang Zhou, Binqing Fu, Rui Sun, Zhigang Tian, Haiming Wei
Summary: This study identified four driver genes (TP53, PTEN, CTNNB1, and KRAS) with high frequency of somatic mutations or copy number variations (CNVs) in HCC patients, and constructed four different spontaneous HCC mouse models to screen for changes in various kinase signaling pathways. The downstream signaling pathway landscapes associated with genomic alterations were identical in HCC patients with the same molecular classification as the mouse models, providing novel targeted therapeutic options for the clinical treatment of HCC.
Article
Oncology
Dong Wang, Xiaohui Li, Defeng Jiao, Ying Cai, Liting Qian, Yiqing Shen, Yichen Lu, Yonggang Zhou, Binqing Fu, Rui Sun, Zhigang Tian, Xiaohu Zheng, Haiming Wei
Summary: The protein expression of LCN2 was found to be higher in the wasting adipose tissue and muscle tissues of the experimental mouse models of lung cancer cachexia. The serum level of LCN2 was associated with cachexia progression in lung cancer patients. Inhibition of LCN2 expression significantly reduced cachexia symptoms and tissue wasting, and antibody depletion of tissue-infiltrating neutrophils (TI-Neu), as well as myeloid-specific-knockout of Lcn2, prevented ferroptosis and tissue wasting in experimental models of lung cancer cachexia. Chemical inhibition of ferroptosis alleviated tissue wasting significantly and prolonged the survival of cachectic mice.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Immunology
Xiaohu Zheng, Zhuanghao Hou, Yeben Qian, Yongwei Zhang, Quanwei Cui, Xuben Wang, Yiqing Shen, Zhenbang Liu, Yonggang Zhou, Binqing Fu, Rui Sun, Zhigang Tian, Guangming Huang, Haiming Wei
Summary: This study reveals that tumor serine metabolism leads to a decrease in membranous protrusions in NK cells, hindering their ability to kill cancer cells. Our current knowledge about how tumors manipulate immune cells is limited, as shown by the variable response rates to immunotherapies. In patients with liver cancer, intratumoral NK cells exhibit fewer membrane protrusions compared to NK cells outside tumors and in peripheral NK cells. The altered sphingomyelin content and dysregulated serine metabolism in intratumoral NK cells contribute to their impaired membrane topology and cytotoxicity. Inhibiting sphingomyelinase shows promising antitumor efficacy as a monotherapy or in combination with checkpoint blockade.
Article
Multidisciplinary Sciences
Chao Qin, Haiyang Li, Shengrui Zhang, Xiaoya Lin, Zhiwei Jia, Fen Zhao, Xiuzhi Wei, Yuanchen Jiao, Zhuang Li, Zhiyuan Niu, Yonggang Zhou, Xiaojiao Li, Hongyu Li, Tao Zhao, Jun Liu, Haiyan Li, Yuping Lu, Fanjiang Kong, Bin Liu
Summary: Soybean flowering time is regulated by photoperiod and controlled by the interaction between GmEID1 and E1 genes. The study shows that the E3/E4-GmEID1-EC module regulates flowering time through the degradation of J protein. Targeted mutations in GmEID1 improve soybean adaptability and yield.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Dongyao Wang, Dong Wang, Min Huang, Xiaohu Zheng, Yiqing Shen, Binqing Fu, Hong Zhao, Xianxiang Chen, Peng Peng, Qi Zhu, Yonggang Zhou, Jinghe Zhang, Zhigang Tian, Wuxiang Guan, Guiqiang Wang, Haiming Wei
Summary: This study analyzed the immune characteristics of retest-positive patients recovered from COVID-19, finding reduced activation and lower granzyme B-producing T cells in these patients. The high expression of ID1 and low expression of IFITM10 were associated with insufficient immune cell activation and the occurrence of retest-positive cases. These findings provide insights into impaired immune function in COVID-19 and the mechanisms underlying retest-positive cases.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Plant Sciences
Wanli You, Jinglin Zhang, Xueyin Ru, Feng Xu, Zhengguo Wu, Peng Jin, Yonghua Zheng, Shifeng Cao
Summary: This study investigated the effect of calcium chloride (CaCl2) treatment on GABA accumulation in fresh-cut cantaloupe and the underlying mechanisms. The results showed that CaCl2 treatment increased GABA content and the activities of GAD and SSADH enzymes, while reducing glutamate content and GABA-T activity. Additionally, CaCl2 treatment upregulated the expressions of CmCML11 and CmCAMTA5, as well as several GABA shunt genes, through the transcriptional activation by CmCAMTA5. Furthermore, the interaction between CmCML11 and CmCAMTA5 enhanced the transcriptional activation of GABA shunt genes. Overall, this study reveals that CaCl2 treatment promotes GABA accumulation in fresh-cut cantaloupe through the combined effect of CmCML11 and CmCAMTA5 in regulating the expressions of GABA shunt genes.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Min Wang, Yupeng Wang, Xiaohui Wang, Guangwei Wei, Huiyi Yang, Xi Yang, Tinghai Shen, Huijie Qu, Sheng Fang, Ziming Wu
Summary: This study identified the high nitrogen use efficiency (NUE) black sesame variety 17-156 and analyzed its underlying physiological and molecular mechanisms. The results showed that 17-156 possesses a sophisticated nitrogen metabolizing machinery to uptake and assimilate higher quantities of inorganic nitrogen, simultaneously improving carbon metabolism and growth. Many important genes were up-regulated in 17-156 under high nitrogen condition. Additionally, 38 potential candidate genes were identified for future studies to improve sesame's NUE. These findings provide valuable resources for understanding the regulatory network of nitrogen metabolism and developing sesame cultivars with improved NUE.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
He Dong, Chongmei Xu, Chengtao Zhang, Li Zhang, Yaqin Yao, Suiqi Zhang
Summary: The study found that short cells in maize leaves not only improve leaf mechanical support and photosynthetic performance, enhance drought resistance, but also participate in stomatal regulation.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Na Liu, Wenyan Shang, Mengxin Guan, Jibin Xiao, Guangxiang Tian, Baozhan Ma, Wenjing Shang, Xu Li, Shijia Zhao, Chuang Li, Kun Cheng, Wenming Zheng
Summary: This study cloned the full-length cDNA sequence of TaSPX3 gene in wheat and found that TaSPX3 responds to low phosphorus stress in multiple wheat genotypes. Overexpressing TaSPX3 can alleviate phosphorus deficiency symptoms and promote plant growth in Arabidopsis. The study also revealed the interaction of TaSPX3 with other genes related to the phosphorus starvation signaling pathway.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Kongyuan Wu, Lizhen Wang, Zihan Wu, Ziqing Liu, Zengfei Li, Jun Shen, Shengjie Shi, Hong Liu, Christopher Rensing, Renwei Feng
Summary: Selenium (Se) can reduce uptake and translocation of cadmium (Cd) in plants by regulating root morphology. This study investigated the effects of Se(IV) on root exudates, root morphology, root endogenous hormones, and Cd uptake efficiency in rice under Cd stress. The results showed that Se(IV) significantly reduced Cd concentrations in shoots and roots, and decreased Cd uptake efficiency via root hairs. Se(IV) also affected root morphology, root exudates, and the synthesis of hormones like IAA and JA. However, transcriptome analysis revealed no upregulated differentially expressed genes (DEGs) in IAA synthesis.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
Article
Plant Sciences
Di Wang, Huaifang Zhang, Xuefei Hu, Haizhen Zhang, Shuang Feng, Aimin Zhou
Summary: This study identified a cell number regulator gene called SlCNR8 in willow, which enhances resistance to trace metals in transgenic poplar seedlings. SlCNR8 reduces Cd uptake and accumulation, and can be used as a candidate gene for genetic improvement of phytostabilisation of trace metals.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2024)
