Article
Oncology
Zai Luo, Zhongmao Fu, Tengfei Li, Yuan Zhang, Jianming Zhang, Yan Yang, Zhengfeng Yang, Qi Li, Zhengjun Qiu, Chen Huang
Summary: Two nomograms were developed to predict survival in patients with left-sided and right-sided colon cancer, demonstrating higher accuracy and clinical net benefits compared to traditional TNM staging, with reliable results shown in calibration plots.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Ruitong Xu, Bingrong Zhou, Ping Hu, Bingyan Xue, Danyang Gu, Xiaolin Li, Qiyun Tang
Summary: This study conducted a retrospective analysis of 1196 patients with colon neuroendocrine neoplasms, and developed and validated nomograms containing various clinically important parameters to predict the prognosis more accurately. The new nomograms showed superior performance in predicting overall survival and cancer-specific survival compared to the AJCC TNM classification.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Jichuan Quan, Junguang Liu, Sicheng Zhou, Shiwen Mei, Wenlong Qiu, Yuanlian Wan, Xishan Wang, Jianqiang Tang
Summary: This study compared the surgical outcomes of extensive resection (EXT) and left hemicolon-sparing resection (LHS) as surgical strategies for synchronous colorectal cancer (SCRC). The results showed that LHS had shorter operative time, better bowel function preservation, and reduced severity of low anterior resection syndrome (LARS) compared to EXT. There were no cases of metachronous cancer in the residual colon and no significant difference in long-term survival rates. Therefore, LHS is a more appropriate surgical strategy for SCRC.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Yuan-Yuan Liu, Bu-Shu Xu, Qiu-Zhong Pan, De-Sheng Weng, Xing Zhang, Rui-Qing Peng
Summary: This study established and validated nomograms for predicting the survival of angiosarcoma patients using clinical information from 785 patients. The nomograms showed good predictive ability and could provide clinicians with better predictions about the clinical outcomes.
Article
Biochemistry & Molecular Biology
So Jeong Yoon, Boram Park, Jaewoo Kwon, Chang-Sup Lim, Yong Chan Shin, Woohyun Jung, Sang Hyun Shin, Jin Seok Heo, In Woong Han
Summary: This study aimed to develop new comprehensive nomograms for predicting prognosis after surgical resection of pancreatic ductal adenocarcinoma (PDAC). Retrospective analysis of clinicopathological data of 885 PDAC patients who underwent surgery between 2006 and 2015 was conducted. Cox regression analysis identified significant factors for recurrence and survival, which were used to create nomograms. Both nomograms showed good predictive performance for recurrence-free survival and overall survival.
Article
Oncology
Shuitang Deng, Jingfeng Ding, Hui Wang, Guoqun Mao, Jing Sun, Jinwen Hu, Xiandi Zhu, Yougen Cheng, Genghuan Ni, Weiqun Ao
Summary: This study explored the value of a deep learning model based on multiparametric magnetic resonance imaging in predicting Ki67 expression in prostate cancer. Multiple prediction models were constructed and the combined model showed superior predictive performance compared to the clinical model.
Article
Oncology
Kun-Han Lee, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Huann-Sheng Wang, Shih-Ching Chang, Yuan-Tzu Lan, Chun-Chi Lin, Hung-Hsin Lin, Sheng-Chieh Huang, Hou-Hsuan Cheng, Yee Chao, Hao-Wei Teng
Summary: Metastatic middle/low rectal cancer shows lower efficacy in anti-EGFR treatment compared to left-sided colon cancer, both in terms of progression-free survival, overall survival, and overall response rates for both first-line and non-first-line treatment. TCGA analysis reveals genetic heterogeneity in rectal tumors, showing shared features with both left- and right-sided colon cancer.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Yuqiang Li, Wenxue Liu, Zhongyi Zhou, Heming Ge, Lilan Zhao, Heli Liu, Xiangping Song, Dan Wang, Qian Pei, Fengbo Tan
Summary: This study developed and validated prognostic nomograms for predicting overall survival and cancer-specific survival in a national cohort of EOLACC patients, identifying the discriminating superiority of the nomograms using various methods and effectively addressing the survival paradox through risk stratification.
Article
Oncology
Yuan Zhou, Changming Lin, Lian Zhu, Rentao Zhang, Lei Cheng, Yuanyuan Chang
Summary: This study established predictive models and a scoring system to predict the survival rate of prostate cancer patients. These tools can help clinicians individually assess the survival status of patients and contribute to clinical decisions.
Article
Oncology
Yilun Li, Li Ma
Summary: By utilizing data from the SEER database, nomograms were developed to predict the overall survival and breast cancer-specific survival of patients with lymph node positive, luminal A breast cancer. These nomograms included factors such as age, marital status, grade, ethnicity, tumor stage, lymph node status, metastasis, surgery, radiotherapy, and chemotherapy. Validation showed good calibration and discrimination of the nomograms in predicting survival outcomes.
Article
Oncology
Hongbo Su, Shanshan Wang, Shuping Xie, Liying Huang, Yunlong Pan, Jun Lyu
Summary: This study aimed to construct competing-risk nomograms for predicting the risk of cancer-specific and non-cancer-specific death in patients with adenocarcinoma of the transverse colon (ATC). The nomograms provide accurate prognostic information and allow for individualized follow-up strategies, ultimately reducing mortality.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Daniela Rega, Vincenza Granata, Antonella Petrillo, Ugo Pace, Massimiliano Di Marzo, Roberta Fusco, Valeria D'Alessio, Guglielmo Nasti, Carmela Romano, Antonio Avallone, Vincenzo Ravo, Fabiana Tatangelo, Piera Maiolino, Raffaele Palaia, Francesco Izzo, Paolo Delrio
Summary: Electrochemotherapy (ECT) has shown effectiveness in treating deep solid tumors. Preliminary results in patients with locally advanced rectal cancer (LARC) treated with ECT demonstrated disease stabilization, pain reduction, and effective local control of recurrence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Tianli Chen, Yue Wang, Zhaodi Nan, Jie Wu, Ailu Li, Tingguo Zhang, Xun Qu, Chen Li
Summary: METs are a potential biomarker for CC patient prognosis and there is a positive feedback loop between CC cells and METs, which can be inhibited by PAD2-IN-1 inhibitors in vitro and in vivo.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Jose Francisco Islas, Adriana G. Quiroz-Reyes, Paulina Delgado-Gonzalez, Hector Franco-Villarreal, Juan Luis Delgado-Gallegos, Elsa N. Garza-Trevino, Carlos A. Gonzalez-Villarreal
Summary: This article summarizes the relationship between gastrointestinal cancer stem cells and the microenvironment, as well as new targeted therapies for modulating cancer cells and the microenvironment. It is of great significance for the management of gastrointestinal cancer.
Article
Gastroenterology & Hepatology
Min Shi, Jian-Wei Tang, Zhi-Rong Cao
Summary: The study developed and validated nomograms for predicting the overall survival of esophageal cancer patients younger than 50 years old, providing clinicians with better understanding of prognostic factors.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Motoi Uchino, Hiroki Ikeuchi, Keisuke Hata, Tomohiro Minagawa, Yuki Horio, Ryuichi Kuwahara, Shiro Nakamura, Kenji Watanabe, Masayuki Saruta, Toshimitsu Fujii, Taku Kobayashi, Ken Sugimoto, Fumihito Hirai, Motohiro Esaki, Sakiko Hiraoka, Katsuyoshi Matsuoka, Shinichiro Shinzaki, Minoru Matsuura, Nagamu Inoue, Hiroshi Nakase, Mamoru Watanabe
Summary: There is a higher incidence of colorectal cancer (CRC) and small bowel cancer (SBC) in patients with Crohn's disease (CD). Patients with anorectal cancer have a shorter survival prognosis, with more reports coming from Asia.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Meeting Abstract
Oncology
Rie Yamamoto, Kaori Komatsuzaki, Yoshiko Kojima, Miwako Inada, Yumi Ooeda, Akiko Nakayama, Saori Chiba, Kiyoe Sato, Hironori Yamaguchi, Hirofumi Fujii
ANNALS OF ONCOLOGY
(2021)
Article
Primary Health Care
Takashi Chinen, Yusuke Sasabuchi, Kazuhiko Kotani, Hironori Yamaguchi
Summary: Primary care physicians are expected to prioritize roles in prevention, diagnosis, and palliative care across the cancer care continuum, although some physicians have lower expectations for their involvement in cancer diagnosis and treatment. Expectations for clinic-based general practitioners' involvement in cancer treatment and survivorship care were not as high as anticipated, indicating potential gaps that need to be addressed.
BMC FAMILY PRACTICE
(2021)
Article
Physics, Multidisciplinary
Hironori Yamaguchi, Taiki Okita, Yoshiki Iwasaki, Yohei Kono, Yuko Hosokoshi, Takanori Kida, Akira Matsuo, Takashi Kawakami, Masayuki Hagiwara
Summary: The magnetic properties of a mixed spin-(1/2, 5/2) chain in a charge-transfer salt were investigated, confirming the formation of the chain and observing a clear LM magnetization plateau. The magnetic susceptibility and specific heat further confirmed the formation of the LM ferrimagnetic state.
JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN
(2021)
Article
Multidisciplinary Sciences
Makoto Ueno, Chigusa Morizane, Takuji Okusaka, Junki Mizusawa, Tomoko Kataoka, Masafumi Ikeda, Masato Ozaka, Naohiro Okano, Kazuya Sugimori, Akiko Todaka, Satoshi Shimizu, Nobumasa Mizuno, Tomohisa Yamamoto, Keiji Sano, Kazutoshi Tobimatsu, Akio Katanuma, Atsushi Miyamoto, Hironori Yamaguchi, Tomohiro Nishina, Hirofumi Shirakawa, Yasushi Kojima, Takamasa Oono, Yasuyuki Kawamoto, Masayuki Furukawa, Tomohisa Iwai, Kentaro Sudo, Hiroyuki Miyakawa, Tatsuya Yamashita, Ichirou Yasuda, Hidenori Takahashi, Naoya Kato, Kazuhiko Shioji, Kyoko Shimizu, Toshio Nakagohri, Ken Kamata, Hiroshi Ishii, Junji Furuse
Summary: The study suggests that gemcitabine plus S-1 (GS) should be chosen for the treatment of advanced biliary tract cancer patients with reduced renal function.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Daisuke Hojo, Koji Murono, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka, Koji Oba, Soichiro Ishihara
Summary: This study suggests that the use of individualized 3-dimensional printed pelvic models can improve the surgical effectiveness of lateral pelvic lymph node dissection, leading to a higher number of harvested lymph nodes. Surgeons can benefit from the detailed procedures guided by the 3-dimensional printed models.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Gastroenterology & Hepatology
Sohei Satoi, Naminatsu Takahara, Tsutomu Fujii, Hiroyuki Isayama, Suguru Yamada, Yasushi Tsuji, Hideyo Miyato, Hironori Yamaguchi, Tomohisa Yamamoto, Daisuke Hashimoto, So Yamaki, Yousuke Nakai, Kei Saito, Hayato Baba, Toru Watanabe, Shigeto Ishii, Masamichi Hayashi, Keisuke Kurimoto, Hideaki Shimada, Joji Kitayama
Summary: This article reviews the clinical diagnosis and treatment of pancreatic ductal adenocarcinoma with peritoneal dissemination and provides recommendations based on clinical questions. The guideline evaluates the quality and evidence of the literature using the GRADE System and provides guidance on diagnostic, chemotherapeutic, and surgical approaches.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Takumi Ando, Shigenobu Emoto, Hiroaki Nozawa, Kazushige Kawai, Kazuhito Sasaki, Koji Murono, Junko Kishikawa, Hiroaki Ishi, Yuichiro Yokoyama, Shinya Abe, Yuzo Nagai, Hiroyuki Anzai, Hirofumi Sonoda, Keisuke Hata, Takeshi Sasaki, Soichiro Ishihara
Summary: We have developed a diagnostic tool using artificial intelligence that accurately predicts the pathology of ulcerative colitis-associated neoplasia, providing a cost-effective and time-saving alternative to conventional methods.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Gastroenterology & Hepatology
Masahiro Kishi, Fumihito Hirai, Noritaka Takatsu, Takashi Hisabe, Yasumichi Takada, Tsuyoshi Beppu, Ken Takeuchi, Makoto Naganuma, Kazuo Ohtsuka, Kenji Watanabe, Takayuki Matsumoto, Motohiro Esaki, Kazutaka Koganei, Akira Sugita, Keisuke Hata, Kitarou Futami, Yoichi Ajioka, Hiroshi Tanabe, Akinori Iwashita, Hirotaka Shimizu, Katsuhiro Arai, Yasuo Suzuki, Tadakazu Hisamatsu
Summary: Clinical and endoscopic indices used in clinical trials for inflammatory bowel disease have been evaluated and reviewed, with the emergence of new indices. Representative indices in clinical trials cover various definitions, including clinical and endoscopic response or remission.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Surgery
Hiroaki Nozawa, Keisuke Hata, Kazuhito Sasaki, Koji Murono, Kazushige Kawai, Shigenobu Emoto, Soichiro Ishihara
Summary: This study compared the outcomes of laparoscopic surgery and open surgery in patients with UC or FAP, and found that laparoscopic surgery resulted in reduced blood loss and promoted bowel recovery, with similar operative time and complication rates compared to open surgery.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
Shigenobu Emoto, Keisuke Hata, Hiroaki Nozawa, Kazushige Kawai, Toshiaki Tanaka, Takeshi Nishikawa, Yasutaka Shuno, Kazuhito Sasaki, Manabu Kaneko, Koji Murono, Yuuki Iida, Hiroaki Ishii, Yuichiro Yokoyama, Hiroyuki Anzai, Hirofumi Sonoda, Soichiro Ishihara
Summary: In this study, risk factors for the pouch not reaching the anus after restorative proctocolectomy were analyzed. Male sex and laparoscopic approach were identified as independent risk factors for non-reaching. Furthermore, a distance between the terminal of the superior mesenteric artery ileal branch and the anus >11 cm was found to be a risk factor for non-reaching. Preoperative CT measurements may be useful in predicting this outcome.
INTESTINAL RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Hiroshi Nakase, Motohiro Esaki, Fumihito Hirai, Taku Kobayashi, Katsuyoshi Matsuoka, Minoru Matsuura, Makoto Naganuma, Masayuki Saruta, Kiichiro Tsuchiya, Motoi Uchino, Kenji Watanabe, Tadakazu Hisamatsu, TRADE Consensus Grp
Summary: The study aimed to develop specific treatment guidelines for patients with different types of Crohn's disease (CD), including luminal CD, CD with perianal disease or fistula, CD with small bowel stenosis, postoperative CD, and patients who need to reduce or discontinue treatment. The study reviewed relevant studies and utilized a modified Delphi process to reach consensus among specialists. The resulting statements provide guidance on treatment intensification and de-intensification for CD patients.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Keigo Matsunaga, Kazuhito Sasaki, Keisuke Hata, Hiroaki Nozawa, Kazushige Kawai, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Hirofumi Sonoda, Koji Ueda, Sho Kuriyama, Takeshi Yamada, Hiroshi Yoshida, Soichiro Ishihara
Summary: This study aimed to investigate the association between the KRAS G13D mutation and anastomotic recurrence (AR) in colorectal cancer (CRC) patients. Results showed that the prevalence of KRAS G13D mutation was significantly higher in the AR group compared to the non-anastomotic local recurrence (NALR) group (AR vs. NALR, 33.3 vs. 4.8%; P=0.047). Furthermore, in the AR group, all patients with KRAS G13D mutation who underwent resection had subsequent recurrence within 2 years after resection, and their overall survival rate was lower (3-year survival rate: Positive vs. negative, 68.6 vs. 90.9%; P=0.02).
Article
Chemistry, Multidisciplinary
Norimichi Nagano, Yuki Ichihashi, Toru Komatsu, Hiroyuki Matsuzaki, Keisuke Hata, Toshiaki Watanabe, Yoshihiro Misawa, Misa Suzuki, Shingo Sakamoto, Yu Kagami, Ayumi Kashiro, Keiko Takeuchi, Yukihide Kanemitsu, Hiroki Ochiai, Rikiya Watanabe, Kazufumi Honda, Yasuteru Urano
Summary: In this study, a fluorogenic substrate probe was developed to analyze enzymatic activity changes in tissue and plasma samples. The probe was particularly useful for studying enzyme activities in a single-molecule enzyme assay platform. We detected the activity of neurolysin in plasma samples and found higher enzyme activity in the blood samples of colorectal tumor patients. The results suggest that single-molecule neurolysin activity could be a promising blood biomarker for colorectal cancer diagnosis.
Article
Multidisciplinary Sciences
Akira Saito, Mineyuki Tojo, Yuko Kumagai, Hideyuki Ohzawa, Hironori Yamaguchi, Hideyo Miyato, Ai Sadatomo, Daishi Naoi, Gaku Ota, Koji Koinuma, Hisanaga Horie, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
Summary: The study evaluated the cell type-specific expression of PD-L1 in colorectal cancer (CRC) specimens, revealing differential expression of PD-L1 in tumor cells, stromal cells, and myeloid cells. PD-L1 expression on tumor cells may be associated with the process of epithelial mesenchymal transition, and quantifying cell type-specific PD-L1 expression using multicolor flow cytometry may provide valuable information for the immunotherapy of solid tumors.
