SGK1 inhibits cellular apoptosis and promotes proliferationviathe MEK/ERK/p53 pathway in colitis

Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2)

(2014) Hao Liu et al.   BIOCHEMICAL JOURNAL

Inflammatory bowel disease

(2014) Daniele Corridoni et al.   IMMUNOLOGY LETTERS

NOD-Like Receptors in Intestinal Homeostasis and Epithelial Tissue Repair

(2014) Marianna Parlato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MEK and the inhibitors: from bench to bedside

(2013) Akintunde Akinleye et al.   Journal of Hematology & Oncology

Upregulation of Intestinal NHE3 Following Saline Ingestion

(2013) Venkanna Pasham et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned from Animal Models and Human Genetics

(2013) Luca Pastorelli et al.   Frontiers in Immunology

Stimulation of Ca2+-channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1)

(2011) Anja Eylenstein et al.   FASEB JOURNAL

Transcription Factor NF-κB Regulates Expression of Pore-forming Ca2+Channel Unit, Orai1, and Its Activator, STIM1, to Control Ca2+Entry and Affect Cellular Functions

(2011) Anja Eylenstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spironolactone improves nephropathy by enhancing glucose-6-phosphate dehydrogenase activity and reducing oxidative stress in diabetic hypertensive rat

(2011) Bruno S Pessôa et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Plasma Corticosterone Activates SGK1 and Induces Morphological Changes in Oligodendrocytes in Corpus Callosum

(2011) Shingo Miyata et al.   PLoS One

Mitogen-Activated Protein Kinases in Mammalian Oxidative Stress Responses

(2010) Christopher Runchel et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of stress-regulated transcription factors by triethylene glycol dimethacrylate monomer

(2010) Stephanie Krifka et al.   BIOMATERIALS

Role of Ras/Raf/MEK/ERK signaling in physiological hematopoiesis and leukemia development

(2010) Eva Chung et al.   IMMUNOLOGIC RESEARCH

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

The physiological impact of the serum and glucocorticoid-inducible kinase SGK1

(2009) Florian Lang et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: Implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration

(2009) Minho Won et al.   JOURNAL OF HEPATOLOGY

Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation

(2009) Rosario Amato et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo

(2009) Shuchen Gu et al.   Molecular Cancer

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumour cell survival signalling by the ERK1/2 pathway

(2008) K Balmanno et al.   CELL DEATH AND DIFFERENTIATION

Wnt Signaling Inhibits Forkhead Box O3a-induced Transcription and Apoptosis through Up-regulation of Serum- and Glucocorticoid-inducible Kinase 1

(2008) Manuel Dehner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane androgen receptor activation triggers down-regulation of PI-3K/AKT/NF-kapaB activity and induces apoptotic responses via BAD, FasL and cacpase 3 in DU145 prostate cancer cells.

(2008) Natalia Papadopoulou et al.   Molecular Cancer