Article
Agricultural Engineering
Kuldeep Kaur, Pritika Singh, Kulwinder Kaur, Abhishek Bhandawat, Panchsheela Nogia, Pratap Kumar Pati
Summary: Withania somnifera is a medicinal plant with immense pharmaceutical potential. In vitro propagation system is used to produce genetically and phytochemically uniform plants, with a multi-step protocol developed to minimize the adverse effects of cytokinin. The protocol also includes modulation of ammonium nitrate strength for in vitro rooting initiation.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Agronomy
Zishan Ahmad, Arjumend Shaheen, Adla Wasi, Shams ur Rehman, Sabaha Tahseen, Muthusamy Ramakrishnan, Anamica Upadhyay, Irfan Bashir Ganie, Anwar Shahzad, Yulong Ding
Summary: This article provides an overview of the medicinal properties of Withania coagulans and discusses conservation strategies and innovative approaches for sustainable utilization.
Article
Pharmacology & Pharmacy
Vivek K. Kashyap, Godwin Peasah-Darkwah, Anupam Dhasmana, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan
Summary: This review highlights the potential of Withania somnifera (WS) as an anticancer and immunomodulatory molecule. Several preclinical studies have shown that WS can prevent or slow the progression of cancer originating from various organs. However, stability, bioavailability, and target specificity are major obstacles in the application of WS for cancer therapy.
Review
Plant Sciences
Sarada D. Tetali, Satyabrata Acharya, Aditya B. Ankari, Vadthyavath Nanakram, Agepati S. Raghavendra
Summary: Withania somnifera, commonly known as Indian ginseng, has been extensively used in Ayurveda for various health benefits. Metabolomic studies have shown that the metabolite profiles of W. somnifera vary depending on plant parts collected, developmental stage, season, and geographical location. The use of sophisticated techniques like LC-MS, GC-MS, HPTLC, and NMR has facilitated the discovery of new metabolites and comprehensive metabolomic profiles.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Subhabrata Paul, Shreya Chakraborty, Uttpal Anand, Swarnali Dey, Samapika Nandy, Mimosa Ghorai, Suchismita Chatterjee Saha, Manoj Tukaram Patil, Ramesh Kandimalla, Jaroslaw Prockow, Abhijit Dey
Summary: Withania somnifera, a traditional Rasayana herb, exhibits potent pharmacological activities against a variety of human medical conditions. Further studies are needed to explore its clinical applications and toxicological properties for safe and efficacious use as a health-promoting herb.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Pukar Khanal, Rupesh Chikhale, Yadu Nandan Dey, Ismail Pasha, Sharad Chand, Nilambari Gurav, Muniappan Ayyanar, B. M. Patil, Shailendra Gurav
Summary: Traditionally used as an immune booster and anti-viral, Withania somnifera contains withanolides which have shown promising potential against COVID-19. Withanolide_G, Withanolide_I, and Withanolide_M from Withania somnifera exhibited the highest binding affinity with PLpro, 3CLpro, and spike protein, respectively. The findings suggest that withanolides could be effective in boosting the immune system and inhibiting COVID-19 infection.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Plant Sciences
Seoung Rak Lee, Bum Soo Lee, Jae Sik Yu, Heesun Kang, Min Jeong Yoo, Sang Ah Yi, Jeung-Whan Han, Sil Kim, Jung Kyu Kim, Jin-Chul Kim, Ki Hyun Kim
Summary: This study identifies withasilolides from Indian ginseng as potential anti-adipogenic compounds for the treatment of obesity and related metabolic diseases.
JOURNAL OF GINSENG RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Arsalan Bashir, Masarat Nabi, Nahida Tabassum, Suhaib Afzal, Mehrose Ayoub
Summary: Ashwagandha, as a significant medicinal plant, has been used in Ayurvedic and indigenous systems of medicine for over 3,000 years. It contains bioactive constituents known as withanolides, which have a broad spectrum of therapeutic potential. Research has shown that Ashwagandha can combat various chronic diseases and has effects on multiple molecular targets.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Helen Holvoet, Dani M. Long, Alexander Law, Christine McClure, Jaewoo Choi, Liping Yang, Luke Marney, Burkhard Poeck, Roland Strauss, Jan F. Stevens, Claudia S. Maier, Amala Soumyanath, Doris Kretzschmar
Summary: Withania somnifera (WS) extracts, widely used in traditional medicine and as nutritional supplements, have shown positive effects on healthy aging, sleep, and resilience against stress. Different extracts may have different beneficial effects due to the variation in active ingredients.
Article
Multidisciplinary Sciences
Mustapha Mbye, Huda Mohamed, Abdul Raziq, Afaf Kamal-Eldin
Summary: The study showed that using 36 mu g/L of W. coagulans, 50 IMCU/L of camel chymosin, 4 h holding time, and 60 degrees C incubation temperature provided the optimal textural hardness for both camel and bovine milk cheeses. Seven treatments were analyzed for physicochemical properties, yield, and SDS-PAGEitation. The results indicated that pure Withania extract resulted in lower coagulating effect, yielding cheeses with low yield, hardness, fat, protein, and total solids.
SCIENTIFIC REPORTS
(2021)
Review
Plant Sciences
Andrzej Patyra, Malgorzata Koltun-Jasion, Oktawia Jakubiak, Anna Karolina Kiss
Summary: Lignans are natural polyphenols with various pharmacological activities, including antimicrobial, anti-inflammatory, hypoglycemic, and cytoprotective effects. They have been found to be associated with a reduced risk of hormone-dependent cancers. Therefore, the extraction, purification, and analysis methods of lignans are crucial in pharmaceutical research.
Review
Biochemistry & Molecular Biology
Muhammad Issa Khan, Maria Maqsood, Raakia Anam Saeed, Amna Alam, Amna Sahar, Marek Kieliszek, Antoni Miecznikowski, Hafiz Shehzad Muzammil, Rana Muhammad Aadil
Summary: Herbal plants, including the valuable medicinal plant Withania coagulans, have been utilized for centuries to treat various health problems with advantages such as minimal side effects. Withania coagulans contains withanolides which give it diuretic, anti-inflammatory, anti-bacterial, and other medicinal properties, making it a potential new drug therapy for multiple diseases.
Article
Food Science & Technology
Salman Ahmadi, Mahmoud Salehi, Solmaz Ausi
Summary: The study on the enzymatic reaction of aspartic protease extracted from Withania coagulans revealed high stability, a strong tendency towards casein hydrolysis, and resistance to thermal denaturation, making it a suitable industrial enzyme.
INTERNATIONAL DAIRY JOURNAL
(2021)
Article
Plant Sciences
Sachin Ashok Thorat, Arya Kaniyassery, Poornima Poojari, Melissa Rangel, Shashikala Tantry, Kodsara Ramachandra Kiran, Manjunath B. Joshi, Padmalatha S. Rai, Anna-Maria Botha, Annamalai Muthusamy
Summary: This study investigated the influence of plant growth regulators on the growth and biosynthesis of bioactive compounds in Ashwagandha at different growth stages. The results show that plant growth regulators can promote plant growth and the synthesis of important bioactive compounds like withanolides.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Saima Maher, Bakht Zamina, Musarat Riaz, Sana Riaz, Noreen Khalid, Muhammad Imran, Shagufta Fahmid, Hina Ishtiaq, Shafia Parveen
Summary: Biosynthesized nanoparticles have emerged as an alternative to traditional methods, and this study introduces a distinctive bioinspired synthesis of zinc oxide nanoparticles using leaf extracts as the reducing agent. The synthesized catalysts were analyzed for their properties and applications, and the results showed promising potential in various fields.
Article
Agronomy
Manisha Meena, Gajanand Jat, R. H. Meena, Roshan Choudhary, Devendra Jain, Kiran Doodhwal, Hemraj Jat, Sharvan Kumar Yadav
Summary: This study demonstrates that the application of phospho enriched compost and zinc can significantly improve the yield, nutrient content, and uptake of blackgram under Typic Haplustepts soil conditions. The combination of 4 t ha(-1) of phospho enriched compost and 4 kg ha(-1) of zinc, along with the recommended dose of fertilizer, results in the best productivity and nutrient effects.
Article
Agronomy
Santosh Ranjan Mohanty, Manoj Parihar, Garima Dubey, Rakesh Parmar, Devendra Jain, Muneshwar Singh, Ashok Patra, Suresh Kumar Chaudhari, Bharati Kollah
Summary: This study estimates nitrification and elucidates the mechanistic processes of nitrogen mineralization in a long-term fertilizer experiment on a soybean-wheat cropping system. The results show that continuous cropping without fertilizer can alter soil microbial metabolism for the acquisition of nitrogen from mineralization of readily unavailable mineral fractions.
ARCHIVES OF AGRONOMY AND SOIL SCIENCE
(2022)
Article
Environmental Sciences
Ali Asger Bhojiya, Harshada Joshi, Sudhir K. Upadhyay, Abhishek K. Srivastava, Vinayak Vandan Pathak, Vimal Chandra Pandey, Devendra Jain
Summary: The soil samples from old Zawar mine sites showed poor soil health due to high content of heavy metals. Bacterial isolates Pseudomonas aeruginosa HMR1 displayed strong potential in promoting plant growth attributes under high concentration of zinc, with optimal zinc adsorption capacity at pH8 and 40 degrees C.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2022)
Article
Engineering, Chemical
Devendra Jain, Himmat Singh Kushwaha, Kuldeep Singh Rathore, Bjorn John Stephen, Hemant Kumar Daima, Rohit Jain, Abhijeet Singh
Summary: Iron oxide (Fe2O3) nanoparticles synthesized through aqueous-gaseous phase reaction show potential as a fertilizer substitute and for soil remediation against industrial wastewater. These nanoparticles exhibit positive surface charge, promoting plant growth and demonstrating good photocatalytic activity.
PARTICULATE SCIENCE AND TECHNOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Sunita Koodi, Kapil Dev Ameta, Ram Avatar Kaushik, Ashok Choudhary, Devendra Jain, Babu Lal Dudwal, Uttam Kumar, Taimoor Hassan Farooq, Aneela Gulnaz, Mohammad Khalid Al-Sadoon
Summary: Overcoming soil fertility limitations and achieving high crop output require effective soil fertility management, such as the combined use of organic and inorganic fertilizers. This study investigated the integrated use of FYM, inorganic fertilizers, and silicon on the development and output parameters of cauliflower. The results showed that the combined application of these components resulted in improved plant height, leaf number, leaf area index, chlorophyll content, stalk length, stem girth, days to curd initiation, days required for marketable curd maturity, plant weight, curd diameter, curd yield, and dry weight of curd compared to the control.
Review
Biotechnology & Applied Microbiology
Surya Chauhan, Sonam Mahawar, Devendra Jain, Sudhir K. Udpadhay, Santosh Ranjan Mohanty, Abhijeet Singh, Elina Maharjan
Summary: This article discusses the role of arbuscular mycorrhiza fungi (AMF) in alleviating biotic and abiotic stresses, as well as the mechanisms for enhancing plant resistance to stress. By establishing successful symbiotic relationships, AMF may become effective agents for plant growth under stress conditions.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Microbiology
Santosh Ranjan Mohanty, Himanshu Mahawar, Apekcha Bajpai, Garima Dubey, Rakesh Parmar, Nagvanti Atoliya, Mayanglambam Homeshwari Devi, Amar Bahadur Singh, Devendra Jain, Ashok Patra, Bharati Kollah
Summary: This study reveals that Methylobacter sp N39 and its carotenoid extract play an important role in counteracting UV radiation stress and can be utilized for managing UV radiation stress in agriculture. The isolate produced beta-carotene and its extract protected E. coli and rhizobium cells from UV radiation damage and enhanced plant resilience to UV irradiation.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Devendra Jain, Jitendra Kumar Navariya, Ali Asger Bhojiya, Abhijeet Singh, Santosh Ranjan Mohanty, Sudhir K. Upadhyay
Summary: In this study, 27 lignin-degrading bacteria (LDB) were isolated from traditional organic manures and their ligninolytic potential was assessed. The results showed that LDB-25 strain had the largest degradation zone on kraft lignin plates, while LDB-23 strain had the largest zone on Guaiacol plates. LDB-9 and LDB-20 strains exhibited the highest lignin degradation ability in kraft lignin and Methylene blue solutions, respectively. Efficient lignin-degrading bacteria were identified through 16SrDNA sequencing, and they have the potential to significantly reduce lignin and lignin-analog contaminants.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Deepak Singh, Devendra Jain, Deepak Rajpurohit, Gajanand Jat, Himmat Singh Kushwaha, Abhijeet Singh, Santosh Ranjan Mohanty, Mohammad Khalid Al-Sadoon, Wajid Zaman, Sudhir K. Upadhyay
Summary: Copper oxide nanoparticles (CuO-NPs) can be used as fungicides and fertilizers, and a specific bacterial strain was found to produce these nanoparticles. The CuO-NPs showed stability and strong antibacterial activity, and they improved the growth characteristics of maize plants.
FRONTIERS IN CHEMISTRY
(2023)
Article
Agronomy
Priyanka J. Chaudhary, B. L. Raghunandan, Hiren K. Patel, Punit V. Mehta, Nainesh B. Patel, Bandeppa Sonth, Anand Dave, Samadhan Y. Bagul, M. Divya, Devendra Jain, Abdulaziz Abdullah Alsahli, Prashant Kaushik
Summary: This study found that the entomopathogenic fungus Metarhizium species can tolerate salt stress and have the potential to improve plant growth and salt tolerance. Metarhizium anisopliae (AAUBC-M15) and Metarhizium pinghaense (AAUBC-M26) showed good tolerance to 200 mM NaCl stress and were effective in reducing salt stress in tomato seedlings.
Article
Agronomy
Iqbal Ahmed, Rajendra Babu Dubey, Devendra Jain, Mohamed A. El-Sheikh, Prashant Kaushik
Summary: Genetic diversity in ashwagandha is limited, but promising hybrid combinations have been identified that show potential for improving yield and alkaloid content. These findings are important for ashwagandha breeding programs.
Article
Environmental Sciences
Aradhana Sukhwal, Devendra Jain, Vimal Sharma, S. N. Ojha, Gajanand Jat, Sudhir K. Mohanty, Abhijeet Singh, Santosh Ranjan Mohanty
Summary: The present research studied the molecular and functional characteristics of native zinc solubilizing bacteria (ZSB) and found that they have a positive effect on plant growth and yield, zinc translocation, and zinc absorption in maize plants. Specifically, Cupriavidus sp. and Pantoea agglomerans strains showed the best results. These findings suggest that these indigenous ZSB strains can be used for soil improvement and crop fortification.
LAND DEGRADATION & DEVELOPMENT
(2023)
Article
Agronomy
Heena Saheewala, Suman Sanadhya, Sudhir Kumar Upadhyay, Santosh Ranjan Mohanty, Devendra Jain
Summary: Potassium-solubilizing bacteria (KSB) have the potential to manage low soil potassium levels and improve crop production. This study isolated and characterized 44 KSB strains from rhizospheric soils in southern Rajasthan, India. The KSB strains exhibited potassium solubilization and showed significant diversity in their molecular profiles. Furthermore, they demonstrated plant growth-promoting activities and improved stress tolerance in maize seedlings.
Article
Biodiversity Conservation
Beerendra Singh, M. K. Mahla, S. Ramesh Babu, Devendra Jain, A. K. Vyas, Virendra Singh, M. L. Ojha, Kuldeep Sharma, Vijay Kumar, Swati Jagawat
Summary: The invasive pest tomato pinworm, Tuta absoluta, was found for the first time in the Udaipur district of Southern Rajasthan, India. Morphological and molecular identification confirmed the occurrence of this new invasive species. The developmental period of T. absoluta has four stages: egg, larva, pupa, and adult.
BIOINVASIONS RECORDS
(2023)
Article
Engineering, Biomedical
Bjorn John Stephen, Ankit Chokriwal, Madan Mohan Sharma, Devendra Jain, Juhi Saxena, Harshdeep Dhaliwal, Vikram Sharma, Rajeev Mishra, Ramandeep Kaur, Abhijeet Singh
Summary: This study describes the preparation and encapsulation of dexamethasone loaded PLGA nanoparticles, optimized using statistical experimental design and response surface methodology. In vitro validation showed the nanodrug to be non-cytotoxic and effective in reducing neuroinflammation.
BIOINSPIRED BIOMIMETIC AND NANOBIOMATERIALS
(2022)