Article
Hematology
Silvia Maria Grazia Trivigno, Mauro Vismara, Ilaria Canobbio, Serena Rustichelli, Federico Galvagni, Maurizio Orlandini, Mauro Torti, Gianni Francesco Guidetti
Summary: The study found that CD93 supports platelet activation triggered by PAR4 stimulation and is required to stabilize the expression of the thrombin receptor on the cell surface.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Chemistry, Analytical
Diana Soukarie, Philippe Rousseau, Maya Salhi, Alexia de Caro, Jean-Marc Escudier, Catherine Tardin, Vincent Ecochard, Laurence Salome
Summary: This study successfully developed an aptasensor based on high-throughput single-molecule techniques, which enables rapid, simple, and sensitive detection of single target molecules. The presence and concentration of the target molecules can be monitored in real time by combining videomicroscopy and image analysis.
ANALYTICAL CHEMISTRY
(2022)
Review
Cardiac & Cardiovascular Systems
Milka Koupenova, Alison C. Livada, Craig N. Morrell
Summary: Platelets not only play important roles in hemostasis and thrombosis, but also have significant immune cell functions. Platelets interact and activate immune cells in response to pathogen exposures, infection, and tissue injury. The immune potential of platelets depends on their molecular composition provided by their megakaryocyte precursor, making them first responders in coordinating pathogen immune responses.
CIRCULATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Agnieszka Polit, Pawel Mystek, Ewa Blasiak
Summary: This passage discusses how individual cell functions in multicellular organisms rely on signal transduction through GPCRs and G proteins, with a focus on the protein-lipid interactions and G proteins' attachment to cell membranes. While the interaction mode between the cell membrane and G proteins is well known, the molecular-level recognition mechanisms and the interrelation of individual G protein-membrane attachment signals in controlling membrane targeting remain unclear.
Article
Multidisciplinary Sciences
Adam B. Schroer, Patrick B. Ventura, Juliana Sucharov, Rhea Misra, M. K. Kirsten Chui, Gregor Bieri, Alana M. Horowitz, Lucas K. Smith, Katriel Encabo, Imelda Tenggara, Julien Couthouis, Joshua D. Gross, June M. Chan, Anthony Luke, Saul A. Villeda
Summary: It is crucial to find therapeutics that can delay or reverse age-related cognitive decline, considering the increasing incidence of dementia-related disorders in the aging population. This study demonstrates that platelet factors can transfer the beneficial effects of young blood to the aging brain. When aged mice were systemically exposed to a fraction of young mouse plasma containing platelets, neuroinflammation in the hippocampus decreased, leading to improvements in hippocampal-dependent cognitive impairments. The study also identified platelet-derived chemokine PF4 as a potential therapeutic target to reduce inflammation and improve cognition in old age.
Article
Cardiac & Cardiovascular Systems
Hideaki Inazumi, Koichiro Kuwahara, Yasuaki Nakagawa, Yoshihiro Kuwabara, Takuro Numaga-Tomita, Toshihide Kashihara, Tsutomu Nakada, Nagomi Kurebayashi, Miku Oya, Miki Nonaka, Masami Sugihara, Hideyuki Kinoshita, Kenji Moriuchi, Hiromu Yanagisawa, Toshio Nishikimi, Hirohiko Motoki, Mitsuhiko Yamada, Sachio Morimoto, Kinya Otsu, Richard M. Mortensen, Kazuwa Nakao, Takeshi Kimura
Summary: NRSF is a transcriptional repressor that suppresses the reactivation of fetal cardiac gene program and maintains cardiac integrity. This study reveals that NRSF regulates ventricular function by controlling the expression of G alpha(o) gene, and excessive expression of G alpha(o) leads to cardiac dysfunction. Additionally, G alpha(o) plays a critical role in cardiac Ca2+ homeostasis and systolic function.
CIRCULATION RESEARCH
(2022)
Article
Hematology
Gina Perrella, Jingnan Huang, Isabella Provenzale, Frauke Swieringa, Floor C. J. Heubel-Moenen, Richard W. Farndale, Mark Roest, Paola E. J. van der Meijden, Mark Thomas, Robert A. S. Ariens, Martine Jandrot-Perrus, Steve P. Watson, Johan W. M. Heemskerk
Summary: The study revealed that fibrin fibers play a consolidating role in microthrombus formation through nonredundant signaling of platelet glycoprotein VI and integrin alpha IIb beta 3 via Syk and low-level Ca2+ rises, even in the absence of thrombin, leading to minimal thrombin generation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stefano Navarro, David Stegner, Bernhard Nieswandt, Johan W. M. Heemskerk, Marijke J. E. Kuijpers
Summary: This study utilized microfluidics technology and pharmacological intervention to acutely block and investigate key pathways of thrombus and clot formation in a short period of time, revealing the crucial roles of certain molecular pathways in the initial minutes of thrombus buildup.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Marta Brambilla, Alessia Becchetti, Gian Enrico Rovati, Nicola Cosentino, Maria Conti, Paola Canzano, Peter L. A. Giesen, Alessia Loffreda, Alice Bonomi, Marco Cattaneo, Erica De Candia, Gian Marco Podda, Daniela Trabattoni, Pablo Jose Werba, Jeness Campodonico, Christian Pinna, Giancarlo Marenzi, Elena Tremoli, Marina Camera
Summary: ADP-induced platelet activation leads to the expression of tissue factor (TF) on the cell surface. The study demonstrates that P2Y(12) receptors play a role in regulating TF expression, and P2Y(12) antagonists can reduce the percentage of TF-positive platelets. Assessment of TF-positive platelets can be used to identify patients with residual platelet reactivity.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ritesh Urade, Yan-Hui Chiu, Chien-Chih Chiu, Chang-Yi Wu
Summary: This article discusses the role of Ras superfamily proteins in the development of the vascular system in zebrafish.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Laura J. Corbin, Stephen J. White, Amy E. Taylor, Christopher M. Williams, Kurt Taylor, Marion T. van den Bosch, Jack E. Teasdale, Matthew Jones, Mark Bond, Matthew T. Harper, Louise Falk, Alix Groom, Georgina G. J. Hazell, Lavinia Paternoster, Marcus R. Munafo, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Stig E. Bojesen, Caroline Relton, Josine L. Min, George Davey Smith, Andrew D. Mumford, Alastair W. Poole, Nicholas J. Timpson
Summary: Epigenetic DNA hypomethylation at the F2RL3 gene induced by smoking may increase PAR4 expression, leading to downstream effects on platelet reactivity. F2RL3 DNA methylation may be a possible contributory pathway from smoking to cardiovascular disease risk.
CIRCULATION RESEARCH
(2022)
Article
Hematology
Matthew L. Kleinjan, De Yu Mao, L. A. Naiche, Jagdish Chandra Joshi, Ahana Gupta, Jordan J. Jesse, Daniel D. Shaye, Dolly Mehta, Jan Kitajewski
Summary: Through studying the role of CLIC1 and CLIC4 in thrombin-induced pathway, it was found that CLIC4 is a critical effector in endothelial PAR1 signaling, regulating RhoA-mediated endothelial barrier disruption. On the other hand, CLIC1 does not play a critical role in thrombin-induced barrier disruption, but contributes to the recovery phase of the barrier.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Hematology
Maria Selvadurai, Moeen Riaz, Sophia Xie, Andrew M. Tonkin, John J. McNeil, Paul Lacaze, Justin R. Hamilton
Summary: This article examines the association between the single-nucleotide polymorphism rs773902 and cardiovascular events and aspirin use. The results indicate that rs773902 is not significantly associated with thrombotic or bleeding events.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biology
Rafal Szelenberger, Michal Seweryn Karbownik, Michal Kacprzak, Ewelina Synowiec, Sylwia Michlewska, Michal Bijak, Marzenna Zielinska, Alina Olender, Joanna Saluk-Bijak
Summary: This study aims to detect potential changes at the molecular level in platelet surface receptors that could be of potential importance in the occurrence of Acute Coronary Syndrome. The results show that the P2Y12 receptor is expressed more frequently among patients, and there are quantitative changes in other platelet receptors important in platelet activation at the genetic level.
Review
Cardiac & Cardiovascular Systems
Franck Paganelli, Marine Gaudry, Jean Ruf, Regis Guieu
Summary: Adenosine, through its A(2A) receptors, plays a crucial role in the coronary artery system by regulating blood circulation and inflammation. Down-regulation of A(2A) receptors in CAD can lead to adverse effects such as reduced vasodilation, increased immune response, and platelet aggregation, contributing to the progression and severity of the disease.
CARDIOVASCULAR RESEARCH
(2021)