Characterization and downstream mannose phosphorylation of human recombinant α-L-iduronidase produced in Arabidopsiscomplex glycan-deficient(cgl) seeds

Treatment options for lysosomal storage disorders: developing insights

(2012) Carin M van Gelder et al.   EXPERT OPINION ON PHARMACOTHERAPY

Drug-making plant blooms

(2012) Amy Maxmen   NATURE

Influence of an ER-retention signal on the N-glycosylation of recombinant human α-l-iduronidase generated in seeds of Arabidopsis

(2012) Xu He et al.   PLANT MOLECULAR BIOLOGY

Production of α-L-iduronidase in maize for the potential treatment of a human lysosomal storage disease

(2012) Xu He et al.   Nature Communications

From Serendipity to Therapy

(2011) Elizabeth F. Neufeld   Annual Review of Biochemistry

Production of active human glucocerebrosidase in seeds of Arabidopsis thaliana complex-glycan-deficient (cgl) plants

(2011) Xu He et al.   GLYCOBIOLOGY

Analysis of Mannose 6-Phosphate Uncovering Enzyme Mutations Associated with Persistent Stuttering

(2011) Wang-Sik Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plant-specific glycosylation patterns in the context of therapeutic protein production

(2010) Véronique Gomord et al.   PLANT BIOTECHNOLOGY JOURNAL

Production of monoclonal antibodies with a controlled N-glycosylation pattern in seeds of Arabidopsis thaliana

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The carboxy-terminal ER-retention motif, SEKDEL, influences the N-linked glycosylation of recombinant human α-l-iduronidase but has little effect on enzyme activity in seeds of Brassica napus and Nicotiana tabacum

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Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor

(2010) Linda J. Olson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions of the α, β, and γ Subunits of UDP-GlcNAc:Lysosomal EnzymeN-Acetylglucosamine-1-phosphotransferase

(2009) Yi Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mucopolysaccharidoses: a success of molecular medicine

(2008) Lorne A. Clarke   EXPERT REVIEWS IN MOLECULAR MEDICINE

Mucopolysaccharidosis I: Management and Treatment Guidelines

(2008) J. Muenzer et al.   PEDIATRICS

Comparative Analyses of Arabidopsis complex glycan1 Mutants and Genetic Interaction with staurosporin and temperature sensitive3a

(2008) J. Frank et al.   PLANT PHYSIOLOGY