A synthetic gene increases TGFβ3 accumulation by 75-fold in tobacco chloroplasts enabling rapid purification and folding into a biologically active molecule

Optimization of the expression of the HIV fusion inhibitor cyanovirin-N from the tobacco plastid genome

(2011) Zouhair Elghabi et al.   PLANT BIOTECHNOLOGY JOURNAL

Expression and characterization of antimicrobial peptides Retrocyclin-101 and Protegrin-1 in chloroplasts to control viral and bacterial infections

(2010) Seung-Bum Lee et al.   PLANT BIOTECHNOLOGY JOURNAL

Low-cost production of proinsulin in tobacco and lettuce chloroplasts for injectable or oral delivery of functional insulin and C-peptide

(2010) Diane Boyhan et al.   PLANT BIOTECHNOLOGY JOURNAL

Identification of protein stability determinants in chloroplasts

(2010) Wiebke Apel et al.   PLANT JOURNAL

The Role of Heterologous Chloroplast Sequence Elements in Transgene Integration and Expression

(2010) T. Ruhlman et al.   PLANT PHYSIOLOGY

Optimization of codon composition and regulatory elements for expression of human insulin like growth factor-1 in transgenic chloroplasts and evaluation of structural identity and function

(2009) Henry Daniell et al.   BMC BIOTECHNOLOGY

Formulation and manufacturability of biologics

(2009) Steven J Shire   CURRENT OPINION IN BIOTECHNOLOGY

Avotermin for the improvement of scar appearance: a new pharmaceutical in a new therapeutic area

(2009) Nick L Occleston et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A hepatitis C virus core polypeptide expressed in chloroplasts detects anti-core antibodies in infected human sera

(2009) P. Madesis et al.   JOURNAL OF BIOTECHNOLOGY

Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies

(2009) Mark WJ Ferguson et al.   LANCET

Plant Physiological Adaptations to the Massive Foreign Protein Synthesis Occurring in Recombinant Chloroplasts

(2009) J. Bally et al.   PLANT PHYSIOLOGY

Insights into Patient and Clinician Concerns about Scar Appearance: Semiquantitative Structured Surveys

(2009) V Leroy Young et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Plastid production of protein antibiotics against pneumonia via a new strategy for high-level expression of antimicrobial proteins

(2009) M. Oey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plant-made vaccine antigens and biopharmaceuticals

(2009) Henry Daniell et al.   TRENDS IN PLANT SCIENCE

New therapeutics for the prevention and reduction of scarring

(2008) Nick L. Occleston et al.   DRUG DISCOVERY TODAY

Prevention and reduction of scarring in the skin by Transforming Growth Factor beta 3 (TGFβ3): from laboratory discovery to clinical pharmaceutical

(2008) Nick L. Occleston et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Plastid transformation of high-biomass tobacco variety Maryland Mammoth for production of human immunodeficiency virus type 1 (HIV-1) p24 antigen

(2008) Matthew S. McCabe et al.   PLANT BIOTECHNOLOGY JOURNAL

Human papillomavirus L1 protein expressed in tobacco chloroplasts self-assembles into virus-like particles that are highly immunogenic

(2008) Alicia Fernández-San Millán et al.   PLANT BIOTECHNOLOGY JOURNAL

High-level expression of human immunodeficiency virus antigens from the tobacco and tomato plastid genomes

(2008) Fei Zhou et al.   PLANT BIOTECHNOLOGY JOURNAL

Exhaustion of the chloroplast protein synthesis capacity by massive expression of a highly stable protein antibiotic

(2008) Melanie Oey et al.   PLANT JOURNAL