Article
Plant Sciences
Rui-Xue Deng, Sheng-Nan Zhou, Xiao Yang, Shuang Zhao, Pu Liu
Summary: Phytochemical investigation of Forsythia suspensa leaves led to the isolation and identification of two new lignan glycosides, Phillyrigeninside B and C, which showed moderate antibacterial and anti-inflammatory activities. This work confirmed the important development value and wide application prospect of furofuran lignan glycosides from F. suspensa leaves.
PHYTOCHEMISTRY LETTERS
(2021)
Review
Genetics & Heredity
Bei Wu, Yinping Li, Wenjia Zhao, Zhiqiang Meng, Wen Ji, Chen Wang
Summary: The study identified 5802 lipid components in Forsythiae Fructus for the first time, providing valuable reference information for further research on metabolic pathways.
FRONTIERS IN GENETICS
(2021)
Article
Chemistry, Analytical
Jidan Zhang, Hongmei Li, Liwei Hou, Jianhui Sun, Weihao Wang, Hua Li, Weipeng Yang, Peijing Rong, Tiegui Nan, Liping Kang, Bin Yang
Summary: This study investigated the pharmacokinetics of five compounds in the stem bark of Magnolia officinalis in both normal and functional dyspepsia rats, revealing significant changes in their absorption and metabolism in pathological states. The main metabolic pathways of honokiol and magnolol were found to be sulfation and glucuronidation.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Chemistry, Analytical
Jidan Zhang, Hongmei Li, Liwei Hou, Jianhui Sun, Weihao Wang, Hua Li, Weipeng Yang, Peijing Rong, Tiegui Nan, Liping Kang, Bin Yang
Summary: This study investigated the pharmacokinetics of five compounds in the stem bark of Magnolia officinalis in both normal and functional dyspepsia rats. The results showed that the residence time of these compounds was significantly decreased in pathological states, except for one compound. The coexisting compounds in the stem bark affected the absorption and elimination of honokiol in vivo. Metabolic profiling analysis identified three prototypes and characterized 35 metabolites, including 18 unknown metabolites.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Microbiology
Kento Sawane, Koji Hosomi, Jonguk Park, Kouta Ookoshi, Hinako Nanri, Takashi Nakagata, Yi-An Chen, Attayeb Mohsen, Hitoshi Kawashima, Kenji Mizuguchi, Motohiko Miyachi, Jun Kunisawa
Summary: In this study, the composition of gut microbiome associated with lignan metabolism was characterized using data from a cross-sectional study in the Japanese population. The study identified the bacterial families Ruminococcaceae and Lachnospiraceae as more abundant in enterolignan producers. Additionally, a random forest classification model was built to classify subjects based on their ability to produce enterolactone using three characteristic bacteria.
Article
Agriculture, Multidisciplinary
Miyo Tanaka, Hisashi Nishiwaki, Satoshi Yamauchi
Summary: A novel tri-substituted tetrahydropyran type 8,7'-neolignan and its enantiomer with higher enantiomeric excess were synthesized from all cis-tetra-substituted tetrahydrofuran with an iodomethyl group. The phytotoxicities of the synthesized compounds were compared to find the most phytotoxic tri-substituted tetrahydropyran type 8,7'-neolignan.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Samuel Amintas, Pauline Beaumont, Charles Dupin, Isabelle Moranvillier, Isabelle Lamrissi, Elie Patel, Benjamin Fernandez, Alice Bibeyran, Julian Boutin, Tristan Richard, Stephanie Krisa, Francois Moreau-Gaudry, Aurelie Bedal, David Cappellen, Benoit Pinson, Veronique Vendrely, Sandrine Dabernat
Summary: This study investigated the differential impact of resveratrol on tumor cells and healthy cells by evaluating its metabolism and the expression of UGT1A genes. The findings revealed that resveratrol was more cytotoxic to tumor cells with downregulated UGTs, while overexpression of UGT1A10 gene reduced its cytotoxicity. Resveratrol also affected the cell cycle, nucleotide metabolism, and global transcription and translation in intestinal sensitive tumor cells. This study enhances our understanding of the antitumor action of resveratrol and provides insights for its selective treatment in colorectal tumors.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Integrative & Complementary Medicine
Duan Hai-Yan, Wang Jian, Zha Liang-Ping, Peng Hua-Sheng, Zhao Yu-Ping, Yuan Yuan, Huang Lu-Qi
Summary: A study identified an O-glucosyltransferase (PtUGT8) in Pueraria thomsonii, which has the ability to glycosylate specific positions of isoflavonoids. The enzyme is inactive towards flavonoids. This discovery may provide a useful catalyst for efficient biotransformation of isoflavonoids and other natural products.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Chemistry, Organic
Qiuyu Zhu, Yu Tang, Biao Yu
Summary: A catalytic glycosyl fluoride activation system using the GeCl2·dioxane-AgBF4 combination was developed, involving reversible activation of C-F bond and reversible chloride ion transfer. This system is easy to operate, proceeds at room temperature, and has a broad scope of substrates.
Review
Pharmacology & Pharmacy
Micaela B. Reddy, Michael B. Bolger, Grace Fraczkiewicz, Laurence Del Frari, Laibin Luo, Viera Lukacova, Amitava Mitra, Joyce S. Macwan, Jim M. Mullin, Neil Parrott, Aki T. Heikkinen
Summary: This study evaluates the use of PBPK modeling as a tool for predicting intestinal metabolism mediated by UGTs in the human gastrointestinal tract. The PBPK models for UGT substrates have shown promise in predicting the extent of intestinal metabolism, indicating the potential utility of PBPK modeling in this area of research.
Article
Plant Sciences
Lindsey N. Aubuchon, Kerstin Schmiederer, Soon Goo Lee
Summary: In this article, the sequence and structural information of structurally characterized plant UGTs involved in plant specialized metabolism is summarized. The study exemplifies the structural biology's role in understanding substrate specificity and developing successful protein engineering strategies using steviol glycosides and their UGT-dependent biosynthetic pathways from Stevia rebaudiana as an example.
PHYTOCHEMISTRY REVIEWS
(2023)
Review
Health Care Sciences & Services
Thomas Helland, Sarah Alsomairy, Chenchia Lin, Havard Soiland, Gunnar Mellgren, Daniel Louis Hertz
Summary: Tamoxifen is an endocrine treatment for hormone receptor positive breast cancer, and its efficacy is determined by the concentration of active metabolites in the body, which may be compromised in patients with metabolic resistance. Researchers have proposed a novel approach to validate this relationship and recommend using a precision endoxifen prediction algorithm to select personalized tamoxifen doses.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Bhawana Israni, Katrin Luck, Samantha C. W. Roemhild, Bettina Raguschke, Natalie Wielsch, Yvonne Hupfer, Michael Reichelt, Ales Svatos, Jonathan Gershenzon, Daniel Giddings Vassao
Summary: Herbivorous insects possess the ability to detoxify chemical defenses from host plants. This study reveals that the fall armyworm regulates its response to DIMBOA through alternative splicing of the SfUGT33F28 transcript, which is mediated by an insect aryl hydrocarbon receptor. The splice variants of SfUGT33F28 interact with the full-length enzyme to modulate its UGT activity towards DIMBOA. Thus, the formation of splice variants induces or represses the DIMBOA-conjugating UGT activity in the presence or absence of DIMBOA, respectively.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Hui Lv, Juanjuan Wang, Mingying Wang, Li Shen, Ling Xiao, Taijie Chen, Tingzhe Sun, Wenjuan Li, Liangliang Zhu, Xiaoke Zhang
Summary: The study showed that TBT and TPT are potent inhibitors of UGTs, interfering with glucuronidation of endogenous hormones and potentially causing endocrine disruption.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Obed Jackson Amoah, Hue Thi Nguyen, Jae Kyung Sohng
Summary: Corynebacterium glutamicum is a food-grade microorganism known for its ability to produce amino acids and recombinant proteins without endotoxins. This study successfully glycosylated therapeutic compounds in C. glutamicum using a glycosyltransferase from Bacillus lichenformis. The conversion rate of glycosylated products was optimized to nearly 96% using glucose as the sole carbon source. This report demonstrates the cultivation and glucosylation of N-linked compounds in C. glutamicum.
Article
Entomology
Kazuo Harada, Yurika Kurono, Saya Nagasawa, Tomoka Oda, Yudai Nasu, Takatoshi Wakabayashi, Yukihiro Sugimoto, Hideyuki Matsuura, Satoru Muranaka, Kazumasa Hirata, Atsushi Okazawa
JOURNAL OF PESTICIDE SCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Toshio Takahashi, Akira Shiraishi, Jun Murata
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Plant Sciences
Eiichiro Ono, Jun Murata, Hiromi Toyonaga, Masaru Nakayasu, Masaharu Mizutani, Masayuki P. Yamamoto, Toshiaki Umezawa, Manabu Horikawa
PLANT AND CELL PHYSIOLOGY
(2018)
Article
Multidisciplinary Sciences
Takumi Ogawa, Koji Kashima, Yoshikazu Yuki, Mio Mejima, Shiho Kurokawa, Masaharu Kuroda, Atsushi Okazawa, Hiroshi Kiyono, Daisaku Ohta
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Masayuki Tera, Tomotsugu Koyama, Jun Murata, Ayako Furukawa, Shoko Mori, Toshiaki Azuma, Takehiro Watanabe, Katsuhito Hori, Atsushi Okazawa, Yasuaki Kabe, Makoto Suematsu, Honoo Satake, Eiichiro Ono, Manabu Horikawa
SCIENTIFIC REPORTS
(2019)
Article
Biotechnology & Applied Microbiology
Atsushi Okazawa, Kenta Yamanishi, Nao Katsuyama, Shohei Kitazawa, Takumi Ogawa, Daisaku Ohta
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2020)
Article
Plant Sciences
Aoi Inaji, Atsushi Okazawa, Taiki Taguchi, Masatoshi Nakamoto, Nao Katsuyama, Ryoka Yoshikawa, Toshiyuki Ohnishi, Frank Waller, Daisaku Ohta
PLANT AND CELL PHYSIOLOGY
(2020)
Article
Plant Sciences
Eiichiro Ono, Toshiyuki Waki, Daiki Oikawa, Jun Murata, Akira Shiraishi, Hiromi Toyonaga, Masako Kato, Naoki Ogata, Seiji Takahashi, Masa-Atsu Yamaguchi, Manabu Horikawa, Toru Nakayama
Article
Plant Sciences
Erisa Harada, Jun Murata, Eiichiro Ono, Hiromi Toyonaga, Akira Shiraishi, Kosuke Hideshima, Masayuki P. Yamamoto, Manabu Horikawa
Article
Biology
Toshio Takahashi, Akira Shiraishi, Jun Murata, Shin Matsubara, Satsuki Nakaoka, Shinji Kirimoto, Masatake Osawa
Summary: Endogenous ACh affects the size of the intestinal stem niche through M3 signaling, impacting the growth and differentiation of intestinal epithelial cells. The EphB/ephrin-B and MAPK/ERK signaling cascade play a crucial role in maintaining the homeostasis of intestinal epithelial cell growth and differentiation.
LIFE SCIENCE ALLIANCE
(2021)
Article
Multidisciplinary Sciences
Tomotsugu Koyama, Erika Matsumoto, Toshimi Okuda, Jun Murata, Manabu Horikawa, Naoki Hata, Atsushi Okazawa, Eiichiro Ono, Honoo Satake
Summary: This study successfully achieved stable and efficient production of sesamin and its precursor piperitol by heterologously expressing the CYP81Q1 gene in Forsythia plants. This provides an important strategy for the cost-effective and scalable production of lignans.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Tomotsugu Koyama, Jun Murata, Manabu Horikawa, Honoo Satake
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jun Murata, Takehiro Watanabe, Hajime Komura
Summary: Research has found that volatile organic compounds released by soil microbes can affect the growth of Arabidopsis through interkingdom signals. Isovaleric acid has been identified as a compound with inhibitory growth activity towards Arabidopsis seedlings.
Article
Plant Sciences
Eiichiro Ono, Jun Murata
Summary: The enormous structural diversity of plant specialized metabolites is primarily attributed to the catalytic specificity of their biosynthetic enzymes. The assembly and maintenance of these metabolic enzyme genes, as well as the presence of identical specialized metabolites in phylogenetically distant lineages, can be explained by the concept of convergent evolution. This review presents recent findings on the co-occurrence of metabolic modules in the plant kingdom and explores how historical and contextual constraints, including the physicochemical properties and genetic presets, contribute to the evolvability of plant specialized metabolism.
PLANT AND CELL PHYSIOLOGY
(2023)