Use of nanoparticles to deliver immunomodulatory oligonucleotides

Effect of TLR Agonists on the Differentiation and Function of Human Monocytic Myeloid-Derived Suppressor Cells

(2015) Jing Wang et al.   JOURNAL OF IMMUNOLOGY

Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors

(2015) T. Sato et al.   MOLECULAR CANCER THERAPEUTICS

Inhibitory/Suppressive Oligodeoxynucleotide Nanocapsules as Simple Oral Delivery Devices for Preventing Atopic Dermatitis in Mice

(2015) Yeqin Wang et al.   MOLECULAR THERAPY

A glucose carbonate apatite complex exhibits in vitro and in vivo anti-tumour effects

(2015) Hirofumi Yamamoto et al.   Scientific Reports

Evaluation of Angiogenesis Using Micro-Computed Tomography in a Xenograft Mouse Model of Lung Cancer

(2015) Rajkumar Savai et al.   NEOPLASIA

Suppressive Oligodeoxynucleotides Inhibit Silica-Induced Pulmonary Inflammation

(2014) T. Sato et al.   JOURNAL OF IMMUNOLOGY

Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

(2014) Julia Scheiermann et al.   VACCINE

Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors

(2014) By Zhao et al.   Journal for ImmunoTherapy of Cancer

Phase 2 trial of erlotinib with or without PF-3512676 (CPG 7909, a Toll-like receptor 9 agonist) in patients with advanced recurrent EGFR-positive non-small cell lung cancer

(2013) Chandra P Belani et al.   CANCER BIOLOGY & THERAPY

Synergistic effect of PKC activation and actin filament disruption on carbonate apatite-facilitated lymphocyte transfection

(2012) K. Fukuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intratumoral Injection of CpG Oligonucleotides Induces the Differentiation and Reduces the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

(2012) Y. Shirota et al.   JOURNAL OF IMMUNOLOGY

Large intestine–targeted, nanoparticle-releasing oral vaccine to control genitorectal viral infection

(2012) Qing Zhu et al.   NATURE MEDICINE

B Cells Contribute to the Antitumor Activity of CpG-Oligodeoxynucleotide in a Mouse Model of Metastatic Lung Carcinoma

(2011) Rosalinda Sorrentino et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A phase III randomized study of gemcitabine and cisplatin with or without PF-3512676 (TLR9 agonist) as first-line treatment of advanced non-small-cell lung cancer

(2011) C. Manegold et al.   ANNALS OF ONCOLOGY

Fluoride enhances transfection activity of carbonate apatite by increasing cytoplasmic stability of plasmid DNA

(2011) E.H. Chowdhury   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Influence of particle size on regional lung deposition – What evidence is there?

(2011) Thiago C. Carvalho et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Induction of Paneth cell degranulation by orally administered Toll-like receptor ligands

(2011) Cristiano Rumio et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Randomized Phase III Trial of Paclitaxel/Carboplatin With or Without PF-3512676 (Toll-Like Receptor 9 Agonist) As First-Line Treatment for Advanced Non–Small-Cell Lung Cancer

(2011) Vera Hirsh et al.   JOURNAL OF CLINICAL ONCOLOGY

CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9

(2010) Takeshi Shimosato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CpG oligodeoxynucleotide promotes protective immunity in the enteric mucosa and suppresses enterotoxigenic E. coli in the weaning piglets

(2010) Qing Cheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Plasmacytoid Dendritic Cells Alter the Antitumor Activity of CpG-Oligodeoxynucleotides in a Mouse Model of Lung Carcinoma

(2010) R. Sorrentino et al.   JOURNAL OF IMMUNOLOGY

Rapid translocation of nanoparticles from the lung airspaces to the body

(2010) Hak Soo Choi et al.   NATURE BIOTECHNOLOGY

Hybrid Polymer-Grafted Multiwalled Carbon Nanotubes for In vitro Gene Delivery

(2010) Antonio Nunes et al.   Small

Therapeutic Applications and Mechanisms Underlying the Activity of Immunosuppressive Oligonucleotides

(2009) Dennis M. Klinman et al.   Annals of the New York Academy of Sciences

Polyketal microparticles for therapeutic delivery to the lung

(2009) Vincent F. Fiore et al.   BIOMATERIALS

Phase I study of TLR9 agonist PF-3512676 in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer

(2009) Kazuhiko Yamada et al.   CANCER SCIENCE

A suppressive oligodeoxynucleotide inhibits ocular inflammation

(2009) C. Fujimoto et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inhaled nanoparticles—A current review

(2008) Wei Yang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS