Article
Biochemistry & Molecular Biology
Edgar Ontsouka, Alessandra Epstein, Sampada Kallol, Jonas Zaugg, Marc Baumann, Henning Schneider, Christiane Albrecht
Summary: The study found significant alterations in placental SLCO3A1 (OATP3A1) gene expression in patients with intrahepatic cholestasis of pregnancy (ICP), while the expression levels of the other 20 genes were comparable between healthy and ICP placentae. Additionally, certain genes in ICP placentae showed positive correlations with BA concentrations and maternal body mass index.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Gal Hershkovitz, Yael Raz, Ilana Goldinger, Ariel Many, Liran Hiersch, Rimon Eli
Summary: Intrahepatic cholestasis of pregnancy (ICP) is characterized by elevated total bile acids (TBA). It is unclear why some fetuses are more prone to the hazardous effect of bile acids (BA) over the others. We aimed to compare TBA levels in umbilical vein and artery to maternal TBA in women with ICP. The study included 18 women and 23 fetuses, and we found that the TBA level in umbilical vein was significantly lower compared to maternal TBA level.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Maciej Majsterek, Magdalena Wierzchowska-Opoka, Inga Makosz, Lena Kreczynska, Zaneta Kimber-Trojnar, Bozena Leszczynska-Gorzelak
Summary: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-related condition characterized by elevated levels of bile acids (BAs) in blood serum and an increased risk of adverse perinatal outcomes. Early diagnosis and prompt management based on BA levels are crucial in reducing fetal complications.
Review
Obstetrics & Gynecology
Antonio F. Saad, Luis D. Pacheco, Lucy Chappell, George R. Saade
Summary: ICP is associated with poor perinatal outcomes in some women, but recent evidence shows that UDCA may not have a significant impact on most perinatal outcomes, therefore a comprehensive approach is needed to manage ICP effectively.
REPRODUCTIVE SCIENCES
(2022)
Article
Medicine, General & Internal
Roberta Granese, Gloria Calagna, Angela Alibrandi, Canio Martinelli, Paola Romeo, Roberto Filomia, Maria Immacolata Ferraro, Eleonora Piccione, Alfredo Ercoli, Carlo Saitta
Summary: The study aimed to evaluate the outcomes of intrahepatic cholestasis of pregnancy (ICP) on both maternal and fetal health. A retrospective case-control study was conducted, including pregnant women diagnosed with ICP between January 2010 and December 2020 at a university hospital. The results showed a higher incidence of hypothyroidism, thrombophilia, gestational diabetes, gestational hypertension, postpartum hemorrhage, and preterm delivery in ICP patients compared to the control group. However, there were no recorded neonatal adverse events and no signs of chronic liver disease in ICP patients during the 24-month follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Xi Yang, Yulai Zhou, Huan Li, Fuzhen Song, Juan Li, Yong Zhang, Yi Lin, Huijuan Zhang, Jianxia Fan, Weibin Wu
Summary: This study revealed the complex interaction among excessive bile acids induced autophagic flux, mitochondrial dysfunction, and cellular apoptosis in placental trophoblasts, which may play a critical role in the pathogenesis of intrahepatic cholestasis of pregnancy (ICP).
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Obstetrics & Gynecology
Rebecca Horgan, Christiana Bitas, Alfred Abuhamad
Summary: This study compared the guidelines for the diagnosis, antepartum surveillance, and timing of delivery of pregnancies complicated by intrahepatic cholestasis of pregnancy published by the Society for Maternal-Fetal Medicine and the Royal College of Obstetricians and Gynaecologists. The two organizations have several key differences in their clinical guidelines, including the criteria for diagnosing intrahepatic cholestasis of pregnancy and the recommended treatments. The Society for Maternal-Fetal Medicine recommends fetal surveillance and specific delivery timing based on bile acid levels, while the Royal College of Obstetricians and Gynaecologists does not recommend additional fetal testing beyond kick count assessment and stratifies delivery timing based on bile acid levels.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Review
Medicine, Research & Experimental
Zhuoqiao Yang, Mengxin Yao, Chunhua Zhang, Xuan Hu, Yi Zhong, Xiangxiang Xu, Jieyun Yin
Summary: This study reviewed metabolomics studies related to intrahepatic cholestasis of pregnancy (ICP), revealing dysregulation of bile acid metabolism and lipid metabolism. Metabolomics shows potential for the diagnosis of ICP.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Ruihong Dong, Yayi Hu, Qian Chen, Dan Shan, Yuxia Wu
Summary: Evidence is presented here that increased expression of GABRP is associated with autophagy and correlated with levels of bile acids in intrahepatic cholestasis of pregnancy (ICP) patients. This suggests that GABRP plays a pivotal role in regulating GABAA receptor's physiological function in ICP patients.
Article
Medicine, General & Internal
Inbar Lifshitz, Geffen Kleinstern, Ori Rottenstreich, Shay Porat, Joshua Rosenbloom, Doron Kabiri, Moshe Rottenstreich, Yosef Ezra, Oren Shibolet, Rifaat Safadi, Amihai Rottenstreich
Summary: The combination of laboratory values (TB, ALK, GGT, AST) was shown to reliably exclude the diagnosis of ICP, particularly useful in settings with limited access to BA levels testing.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Developmental Biology
Yuxuan Jiang, Xiaoping Yin, Qian Xu, Xiaoxiao Tang, Huajie Zhang, Xueshan Cao, Jing Lin, Yi Wang, Fei Yang, Naseer Ullah Khan, Liming Shen, Danqing Zhao
Summary: Using the SWATH proteomic method, this study identified potential proteins in placental tissue that may be involved in the pathogenesis of intrahepatic cholestasis of pregnancy (ICP). The differentially expressed proteins (DEPs) found were associated with immune response, cell response to lipopolysaccharide, antioxidant activity, and heme metabolism. Further analysis revealed the involvement of death domain receptors and fibrinogen complexes in regulating apoptotic signaling pathways, blood coagulation, and fibrin clot formation.
Article
Physiology
Wenhu Liu, Qiang Wang, Jinxia Chang, Anup Bhetuwal, Nisha Bhattarai, Xin Ni
Summary: This study revealed the metabolomic profiles in circulation and the correlation of the metabolites with clinical features in intrahepatic cholestasis of pregnancy (ICP) patients. The data suggest that disturbances in metabolic pathways might be associated with adverse pregnancy outcomes.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Plant Sciences
Shasha Qin, Jingzhuo Tian, Yong Zhao, Lianmei Wang, Jinyu Wang, Suyan Liu, Jing Meng, Fang Wang, Chenyue Liu, Jiayin Han, Chen Pan, Yushi Zhang, Yan Yi, Chunying Li, Meiting Liu, Aihua Liang
Summary: This study aims to systematically elucidate the mechanism by which Gardenia extract ameliorates ANIT-induced cholestatic liver injury.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Gastroenterology & Hepatology
Tharni Vasavan, Sahil Deepak, Indu Asanka Jayawardane, Maristella Lucchini, Catherine Martin, Victoria Geenes, Joel Yang, Anita Lovgren-Sandblom, Paul Townsend Seed, Jenny Chambers, Sophia Stone, Lesia Kurlak, Peter Hendy Dixon, Hanns-Ulrich Marschall, Julia Gorelik, Lucy Chappell, Pam Loughna, Jim Thornton, Fiona Broughton Pipkin, Barrie Hayes-Gill, William Paul Fifer, Catherine Williamson
Summary: Elevated fetal and maternal serum bile acid concentrations in untreated ICP are associated with an abnormal fetal cardiac phenotype characterized by increased NT-proBNP concentration, PR interval length and HRV. UDCA treatment partially attenuates this phenotype.
JOURNAL OF HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yifan He, Xiaoqing Zhang, Yong Shao, Biao Xu, Yue Cui, Xiao Chen, Hong Chen, Can Luo, Min Ding
Summary: The risk of adverse fetal outcomes was significantly higher in the AHP group compared to normal pregnancies but lower than the ICP group. Multivariate statistics analysis revealed distinct serum BAs metabolic profiling among the three groups, with elevated levels of deoxycholic acid species in the AHP group. Overall, AHP had unique clinical features and serum BAs metabolism compared to ICP and normal pregnancies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Obstetrics & Gynecology
Maria Andrikopoulou, Elisa T. Bushman, Madeline M. Rice, William A. Grobman, Uma M. Reddy, Robert M. Silver, Yasser Y. El-Sayed, Dwight J. Rouse, George R. Saade, John M. Thorp, Suneet P. Chauhan, Maged M. Costantine, Edward K. Chien, Brian M. Casey, Sindhu K. Srinivas, Geeta K. Swamy, Hyagriv N. Simhan
Summary: This study aimed to evaluate the impact of different cervical ripening methods on maternal and neonatal outcomes among low-risk nulliparous individuals. The results showed that compared to using prostaglandin only, using Foley catheter with prostaglandin or Foley catheter alone was associated with a lower risk of adverse neonatal outcomes. Moreover, labor induction with Foley catheter and concurrent oxytocin resulted in the shortest duration of labor and delivery stay.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Letter
Obstetrics & Gynecology
Katherine L. Grantz, Jagteshwar Grewal, Sungduk Kim, William A. Grobman, Roger B. Newman, John Owen, Anthony Sciscione, Daniel Skupski, Edward K. Chien, Deborah A. Wing, Ronald J. Wapner, Angela C. Ranzini, Michael P. Nageotte, Sabrina Craigo, Stefanie N. Hinkle, Mary E. D'Alton, Dian He, Fasil Tekola-Ayele, Mary L. Hediger, Germaine M. Buck Louis, Cuilin Zhang, Paul S. Albert
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Maged M. Costantine, Madeline Murguia Rice, Mark B. Landon, Michael W. Varner, Brian M. Casey, Uma M. Reddy, Ronald J. Wapner, Dwight J. Rouse, Alan T. N. Tita, John M. Thorp, Edward K. Chien, Alan M. Peaceman, Sean C. Blackwell
Summary: This study aims to evaluate whether the values and shape of the glucose curve during an oral glucose tolerance test (OGTT) in pregnancy can identify women at risk of developing hypertension later in life. The results suggest that the 2-hour OGTT value was positively associated with the primary outcome, while the 3-hour OGTT value was negatively associated. Furthermore, a monophasic OGTT response was associated with an increased risk of hypertension.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Jessica Pippen, Bethany Stetson, Lindsay Doherty, Michael W. Varner, Brian M. Casey, Uma M. Reddy, Ronald J. Wapner, Dwight J. Rouse, Alan T. N. Tita, John M. Thorp, Edward K. Chien, George R. Saade, Sean C. Blackwell
Summary: The study found that birthweight and early infancy feeding practices are not associated with alterations in leptin and adiponectin levels in children of women with mild GDM.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Michal Fishel Bartal, Ashish Premkumar, Madeline Murguia Rice, Uma M. Reddy, Alan T. N. Tita, Robert M. Silver, Yasser Y. El-Sayed, Ronald J. Wapner, Dwight J. Rouse, George R. Saade, John M. Thorp, Maged M. Costantine, Edward K. Chien, Brian M. Casey, Sindhu K. Srinivas, Geeta K. Swamy, Hyagriv N. Simhan
Summary: This secondary analysis of a randomized trial found that almost 14% of low-risk nulliparous women who were expectantly managed at or after 39 weeks developed hypertensive disorders of pregnancy (HDP), and they were more likely to experience adverse maternal outcomes compared to those who did not develop HDP.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Dwight J. Rouse, Lida M. Fette, Brenna L. Hughes, George R. Saade, Mara J. Dinsmoor, Uma M. Reddy, Robert Pass, Donna Allard, Gail Mallett, Rebecca G. Clifton, Frances M. Saccoccio, Sallie R. Permar, Cynthia Gyamfi-Bannerman, Michael W. Varner, William H. Goodnight, Alan T. N. Tita, Maged M. Costantine, Geeta K. Swamy, Kent D. Heyborne, Edward K. Chien, Suneet P. Chauhan, Yasser Y. El-Sayed, Brian M. Casey, Samuel Parry, Hyagriv N. Simhan, Peter G. Napolitano, George A. Macones
Summary: We developed and internally validated a non-invasive method for predicting congenital CMV infection after primary maternal CMV infection. The models showed moderate discriminatory ability and can be useful for patient counseling and decision making.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Michelle P. Debbink, Lynda G. Ugwu, William A. Grobman, Uma M. Reddy, Alan T. N. Tita, Yasser Y. El-Sayed, Ronald J. Wapner, Dwight J. Rouse, George R. Saade, John M. Thorp, Suneet P. Chauhan, Maged M. Costantine, Edward K. Chien, Brian M. Casey, Sindhu K. Srinivas, Geeta K. Swamy, Hyagriv N. Simhan
Summary: This study found that non-Hispanic Black and Hispanic low-risk nulliparous individuals at term undergo cesarean birth more frequently than low-risk non-Hispanic White nulliparous individuals. This difference accounts for a modest portion of excess maternal morbidity.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Beth A. Plunkett, Steven J. Weiner, George R. Saade, Michael A. Belfort, Sean C. Blackwell, John M. Thorp, Alan T. N. Tita, Russell S. Miller, David S. McKenna, Edward K. S. Chien, Dwight J. Rouse, Yasser Y. El-Sayed, Yoram Sorokin, Steve N. Caritis
Summary: ST changes in fetal ECG occur more frequently in fetuses of diabetic mothers during labor. This may indicate fetal cardiac hypoxia.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Roger B. Newman, Danielle R. Stevens, Kelly J. Hunt, William A. Grobman, John Owen, Anthony Sciscione, Ronald J. Wapner, Daniel Skupski, Edward K. Chien, Deborah A. Wing, Angela C. Ranzini, Manuel Porto, Katherine L. Grantz
Summary: This study aimed to evaluate fetal biometrics as predictors of shoulder dystocia (SD) in a low-risk obstetrical population. The results showed that, apart from the use of epidural anesthesia, there were no significant associations between sociodemographic or maternal anthropometrics and SD in this low-risk population. Fetal biometrics had limited ability to predict SD and lack clinical usefulness.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Sport Sciences
Susanna D. Mitro, Shyamal Peddada, Jessica L. Gleason, Dian He, Brian Whitcomb, Lindsey Russo, Jagteshwar Grewal, Cuilin Zhang, Samrawit F. Yisahak, Stefanie N. Hinkle, Germaine M. Buck Louis, Roger Newman, William Grobman, Anthony C. Sciscione, John Owen, Angela Ranzini, Sabrina Craigo, Edward Chien, Daniel Skupski, Deborah Wing, Katherine L. Grantz
Summary: This study investigated longitudinal activity during singleton and twin pregnancies by activity domain and maternal characteristics. The findings showed that household/caregiving activity accounted for the largest fraction of reported activity, followed by occupational activity. However, overall activity levels declined significantly during pregnancy. Non-Hispanic Black women reported higher activity levels than other racial/ethnic groups at baseline. Nulliparous women and women with singleton gestations reported lower activity levels compared to parous women and women with twins, respectively.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Obstetrics & Gynecology
Maged M. Costantine, Grecio J. Sandoval, William A. Grobman, Uma M. Reddy, Alan T. N. Tita, Robert M. Silver, Yasser Y. El-Sayed, Ronald J. Wapner, Dwight J. Rouse, George R. Saade, John M. Thorp, Suneet P. Chauhan, Edward K. Chien, Brian M. Casey, Sindhu K. Srinivas, Geeta K. Swamy, Hyagriv N. Simhan
Summary: Among low-risk nulliparous people, higher BMI was associated with a longer time from admission to delivery, longer total hospital LOS, and more frequent utilization of intrapartum and postpartum resources.
OBSTETRICS AND GYNECOLOGY
(2022)
Letter
Obstetrics & Gynecology
Katherine L. Grantz, Jagteshwar Grewal, Sungduk Kim, William A. Grobman, Roger B. Newman, John Owen, Anthony Sciscione, Daniel Skupski, Edward K. Chien, Deborah A. Wing, Ronald J. Wapner, Angela C. Ranzini, Michael P. Nageotte, Sabrina Craigo, Stefanie N. Hinkle, Mary E. D'Alton, Dian He, Fasil Tekola-Ayele, Mary L. Hediger, Germaine M. Buck Louis, Cuilin Zhang, Paul S. Albert
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Erin M. Cleary, Douglas A. Kniss, Lida M. Fette, Brenna L. Hughes, George R. Saade, Mara J. Dinsmoor, Uma M. Reddy, Cynthia Gyamfi-Bannerman, Michael W. Varner, William H. Goodnight, Alan T. N. Tita, Geeta K. Swamy, Kent D. Heyborne, Edward K. Chien, Suneet P. Chauhan, Yasser Y. El-Sayed, Brian M. Casey, Samuel Parry, Hyagriv N. Simhan, Peter G. Napolitano
Summary: In a cohort of parturients with primary CMV infection, nicotine exposure was not associated with offspring hearing dysfunction assessed with DPOAEs.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Ashley N. Battarbee, Lisa Mele, Mark B. Landon, Michael W. Varner, Brian M. Casey, Uma M. Reddy, Ronald J. Wapner, Dwight J. Rouse, John M. Thorp, Edward K. Chien, George Saade, Beth A. Plunkett, Sean C. Blackwell
Summary: The objective of this study was to evaluate the association between mild gestational diabetes mellitus (GDM) and obesity with metabolic and cardiovascular markers 5 to 10 years after pregnancy. The results showed that prior GDM and obesity were associated with increased insulin resistance but no consistent cardiovascular dysfunction or alterations in insulin secretion.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Multidisciplinary Sciences
Peter H. Dixon, Adam P. Levine, Ines Cebola, Melanie M. Y. Chan, Aliya S. Amin, Anshul Aich, Monika Mozere, Hannah Maude, Alice L. Mitchell, Jun Zhang, Jenny Chambers, Argyro Syngelaki, Jennifer Donnelly, Sharon Cooley, Michael Geary, Kypros Nicolaides, Malin Thorsell, William M. Hague, Maria Cecilia Estiu, Hanns-Ulrich Marschall, Daniel P. Gale, Catherine Williamson
Summary: The study identified multiple genetic signals associated with intrahepatic cholestasis of pregnancy (ICP), shedding light on the disease which can lead to preterm birth and stillbirth. Common sequence variation in liver-enriched genes and liver-specific cis-regulatory elements were pinpointed as contributing mechanisms to ICP susceptibility.
NATURE COMMUNICATIONS
(2022)