Article
Biochemistry & Molecular Biology
Maranda Thompson, Arzu Ulu, Ana G. Yuil-Valdes, Maheswari Mukherjee, Melissa Thoene, Matthew Van Ormer, Rebecca Slotkowski, Elizabeth Lyden, Ann Anderson Berry, Corrine K. Hanson, Tara M. Nordgren, Sathish Kumar Natarajan
Summary: This study aims to investigate the effects of oxylipins on fetal growth. A diverse panel of oxylipins, originating from the lipoxygenase pathway, was identified in maternal and umbilical cord plasma. Both omega-3 and omega-6 oxylipins demonstrated potential influences on birth length and weight percentiles, suggesting that oxylipins present during pregnancy may serve as biomarkers for infant outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Esther lvarez-Silvares, Tania Fernandez-Cruz, Monica Bermudez-Gonzalez, Paula Rubio-Cid, Agostinho Almeida, Edgar Pinto, Teresa Seoane-Pillado, Elena Martinez-Carballo
Summary: Placental development plays a crucial role in the progression of pregnancy, and exposure to environmental toxicants, including metals, can have an impact on placenta and subsequently affect pregnancy outcomes. This study investigates the correlation between placental levels of 14 essential and non-essential elements and neonatal weight. The findings suggest that certain metal concentrations in the placenta may influence fetal growth, with cobalt and strontium associated with higher newborn weight, while lithium, molybdenum, and selenium associated with lower newborn weight.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Samantha M. Hall, Sharon Zhang, Kate Hoffman, Marie Lynn Miranda, Heather M. Stapleton
Summary: There are associations between placental PFAS concentrations and birth outcomes, suggesting potential effects of PFAS on fetal health.
Article
Environmental Sciences
Maimaitiminjiang Wulayin, Zhenghong Zhu, Huailin Wang, Xin Chen, Xiaoxin Zhang, Tarik Benmarhnia, Jiajun Luo, Qianhong Liang, Weiyi Chen, Hualiang Lin, Yuewei Liu, Chunxiang Shi, Ruijun Xu, Cunrui Huang, Qiong Wang
Summary: Studies have shown that exposure to low and high temperatures during pregnancy has negative effects on fetal development. The placenta, which plays a crucial role in fetal development, may also be affected by suboptimal temperatures. However, it is unclear whether the placenta mediates the association between suboptimal temperature and birth weight.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Endocrinology & Metabolism
Guicun Yang, Nianrong Wang, Hao Liu, Lina Si, Yan Zhao
Summary: This study found that the infant's birth weight is associated with the levels of cord blood vitamins A and E. Dysregulation of vitamins A and E in infants may be a risk factor for fetal growth and future metabolic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Acoustics
C. Ebbing, S. Rasmussen, J. Kessler, D. Moster
Summary: This study found that abnormalities of the umbilical cord or placenta are associated with cerebral palsy (CP), regardless of gestational age or sex of the child.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Agriculture, Dairy & Animal Science
P. Langendijk, M. Fleuren, G. Page
Summary: Birth weight is important for piglet survival, and there is ongoing interest in understanding the impact of nutrition during gestation on birth weight. This paper reviews previous attempts to increase birth weight and proposes targeting specific windows of gestation for nutritional manipulations. The mean birth weight needs to be increased by at least 50-100 g to improve survival rates for piglets with a birth weight below 1 kg. However, it is unlikely that the mean birth weight can be increased by more than 100 g based on existing studies. Nutritional manipulations during the middle of gestation or during the embryonic phase may be more effective.
Article
Medicine, General & Internal
Elena Contro, Laura Larcher, Jacopo Lenzi, Marina Valeriani, Antonio Farina, Eric Jauniaux
Summary: In fetuses with isolated single umbilical artery (SUA), the diameter of the remaining umbilical artery is significantly larger than in control fetuses. A diameter of <3.1 mm in the remaining artery is associated with a higher risk of fetal growth restriction (FGR). This study highlights the importance of measuring the diameter of the remaining artery to identify fetuses at risk of FGR.
Article
Developmental Biology
L. Larcher, E. Jauniaux, J. Lenzi, R. Ragnedda, D. Morano, M. Valeriani, G. Michelli, A. Farina, E. Contro
Summary: In this prospective cohort study, we found that placental and umbilical cord anomalies are more common in IVF singleton pregnancies compared to spontaneous pregnancies. We also identified oocyte donor fertilization as an additional risk factor for the development of these anomalies. Ultrasound examinations play a crucial role in screening for these anomalies.
Article
Environmental Sciences
Keiko Yamasaki, Naomi Mitsuda, J-P Naw Awn, Masamitsu Eitoku, Nagamasa Maeda, Mikiya Fujieda, Narufumi Suganuma
Summary: This study found a positive correlation between maternal urinary cotinine concentration and placental weight and the ratio of placental weight to birth weight. After reaching a certain concentration, placental weight decreased in male offspring while it plateaued in female offspring. Active smoking during pregnancy significantly increased both placental weight and placental weight to birth weight ratio.
ENVIRONMENTAL RESEARCH
(2022)
Article
Pediatrics
Anjum Shakya, Nisha Keshary Bhatta, Rupa Rajbhandari Singh, Shankar Prasad Yadav, Jitendra Thakur
Summary: This study aimed to develop gestational age specific percentile charts of birth weight, length, and head circumference for neonates. The percentile charts can be used as a reference for the local population and potentially establish a national reference curve for healthy neonates across different regions.
Article
Acoustics
J. Semmler, S. Abdel-Azim, S. Anzoategui, H. Zhang, K. H. Nicolaides, M. Charakida
Summary: Echocardiographic studies have shown that fetuses with low birth weight have more globular hearts and reduced cardiac function compared to those with normal birth weight. The study aimed to explore the associations between fetal cardiac morphology and function, birth weight, UtA-PI, and CPR. The findings suggest that differences in fetal cardiac indices between small and appropriately grown fetuses may be part of a normal physiological response to change in fetal size rather than a pathological adaptation to abnormal placental perfusion and fetal oxygenation.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Sadan Tutus, Nese Asal, Gulsum Uysal, Hatice Sahin
Summary: The study found an inverse relationship between umbilical vein diameter and birth weight of large gestational age (LGA) newborns at 20-24 weeks of pregnancy. Other parameters showed no significant relationship with birth weight of LGA newborns.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Cell & Tissue Engineering
Meijuan Tu, Aijie Huang, Lijuan Ning, Baolin Tang, Chunli Zhang, Guangyu Sun, Xiang Wan, Kaidi Song, Wen Yao, Ping Qiang, Yue Wu, Xiaoyu Zhu
Summary: The study established a predictive model combining clinical and nutritional factors to predict overall survival in UCBT recipients. High-risk score, calf skinfold thickness, and low albumin level were associated with survival post-UCBT.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Medicine, General & Internal
Simeon Meskele Leyto, Kusse Urmale Mare
Summary: Placental parameters, particularly weight and thickness, as well as gestational age, have a significant influence on low birth weight. Therefore, proper examination of the placenta should be performed routinely following delivery for better newborn care.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Editorial Material
Pediatrics
Maria Ann Mannion, Brendan Fitzgerald, Peter Filan
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2016)
Article
Medicine, Research & Experimental
Cassie Fives, Andreea Nae, Phoebe Roche, Gerard O'Leary, Brendan Fitzgerald, Linda Feeley, Patrick Sheahan
Article
Otorhinolaryngology
Nicola M. Hughes, Andreea Nae, Josephine Barry, Brendan Fitzgerald, Linda Feeley, Patrick Sheahan
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2017)
Review
Immunology
Brendan Fitzgerald
Article
Developmental Biology
S. Schrey, J. Kingdom, D. Baczyk, B. Fitzgerald, S. Keating, G. Ryan, S. Drewlo
MOLECULAR HUMAN REPRODUCTION
(2013)
Article
Otorhinolaryngology
Patrick Sheahan, Mohamed Mohamed, Carmel Ryan, Linda Feeley, Brendan Fitzgerald, Julie McCarthy, Antoinette Tuthill, Matthew S. Murphy
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2014)
Article
Obstetrics & Gynecology
Khadijah I. Ismail, Ailish Hannigan, Peter Kelehan, Brendan Fitzgerald, Keelin O'Donoghue, Amanda Cotter
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2020)
Article
Developmental Biology
Grace Neville, Noirin Russell, Keelin O'Donoghue, Brendan Fitzgerald
Review
Developmental Biology
Laura Linehan, Keelin O'Donoghue, Susan Dineen, Jessica White, John R. Higgins, Brendan Fitzgerald
Summary: SARS-CoV-2 infection during pregnancy can lead to placental infection, posing a threat to the fetus, though this situation is relatively rare.
Article
Medical Laboratory Technology
David A. Schwartz, Marcella Baldewijns, Alexandra Benachi, Mattia Bugatti, Gaetano Bulfamante, Ke Cheng, Rebecca R. J. Collins, Larisa Debelenko, Daniele De Luca, Fabio Facchetti, Brendan Fitzgerald, Daniel Levitan, Rebecca L. Linn, Lukas Marcelis, Denise Morotti, Raffaella Morotti, Luisa Patane, Sophie Prevot, Bianca Pulinx, Ali G. Saad, Sam Schoenmakers, David Strybol, Kristen Thomas, Delfina Tosi, Valentina Toto, Lotte E. Van der Meeren, Robert M. Verdijk, Alexandre J. Vivanti, Mehreen Zaigham
Summary: The study found that SARS-CoV-2 can extend beyond the syncytiotrophoblast to enter other villous stromal cells in the placenta, including Hofbauer cells and capillary endothelial cells. Infection of Hofbauer cells and villous capillary endothelial cells in the placenta is uncommon.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Medical Laboratory Technology
David A. Schwartz, Elyzabeth Avvad-Portari, Pavel Babal, Marcella Baldewijns, Marie Blomberg, Amine Bouachba, Jessica Camacho, Sophie Collardeau-Frachon, Arthur Colson, Isabelle Dehaene, Joan Carles Ferreres, Brendan Fitzgerald, Marta Garrido-Pontnou, Hazem Gergis, Beata Hargitai, A. Cecilia Helguera-Repetto, Sandra Holmstrom, Claudine Liliane Irles, Asa Leijonhfvud, Sasha Libbrecht, Tamas Marton, Noel McEntagart, James T. Molina, Raffaella Morotti, Alfons Nadal, Alexandra Navarro, Maria Nelander, Angelica Oviedo, Andre Ricardo Oyamada Otani, Nikos Papadogiannakis, Astrid C. Petersen, Drucilla J. Roberts, Ali G. Saad, Anna Sand, Sam Schoenmakers, Jennifer K. Sehn, Preston R. Simpson, Kristen Thomas, M. Yolotzin Valdespino-Vazquez, Lotte E. van der Meeren, Jo Van Dorpe, Robert M. Verdijk, Jaclyn C. Watkins, Mehreen Zaigham
Summary: This study evaluated the mechanism of stillbirth and neonatal death following maternal infection with COVID-19. The findings suggest that placental abnormalities caused by SARS-CoV-2 infection result in placental malperfusion and insufficiency, leading to fetal hypoxic-ischemic injury and perinatal death.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Article
Medical Laboratory Technology
Brendan Fitzgerald, Keelin O'Donoghue, Noel McEntagart, John E. Gillan, Peter Kelehan, John O'Leary, Paul Downey, Jonathan Dean, Cillian F. De Gascun, John Bermingham, Fionnvola Armstrong, Attia Al Fathil, Nicola Maher, Cliona Murphy, Louise Burke
Summary: A severe third wave of COVID-19 in Ireland resulted in 1 second-trimester miscarriage and 6 stillbirths due to SARS-CoV-2 placentitis. The presence of SARS-CoV-2 alpha in all cases suggests an increased risk of fetal death compared to the original virus. Maternal thrombocytopenia may serve as a potential clinical marker of placentitis, and there may be a window for intervention in some cases.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Review
Pathology
Carla Bartosch, Alfons Nadal, Ana C. Braga, Angela Salerno, Anne-Laure Rougemont, Anne-Sophie Van Rompuy, Brendan Fitzgerald, Caroline Joyce, Fabienne Allias, Geoffrey J. Maher, Gitta Turowski, Jean-Christophe Tille, Kinan Drak Alsibai, Koen van de Vijver, Lesley Mcmahon, Lone Sunde, Michal Pyzlak, Paul Downey, Sandra Wessman, Sophie Patrier, Baljeet Kaur, Rosemary Fisher
Summary: Hydatidiform moles are rare and require prompt and accurate identification due to their potential premalignant nature. Diagnosis can be improved through the use of standardized diagnostic criteria and algorithms.
Article
Obstetrics & Gynecology
Abi Merriel, Brendan Fitzgerald, Keelin O'Donoghue
Summary: SARS-CoV-2 has had a significant impact on pregnancy outcomes, with a clear link between the virus and poor fetal outcome observed during the Alpha and Delta waves. Some women who contract COVID-19 develop SARS-CoV-2 placentitis, which has been associated with intrauterine fetal death. Surprisingly, SARS-CoV-2 placentitis is often not associated with severe maternal COVID-19 infection, making prediction difficult.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
D. Nuzum, B. Fitzgerald, M. J. Evans, K. O'Donoghue
Summary: Perinatal autopsy rates have significantly declined in recent decades, but there is a lack of consensus on the potential religious influences in decision making. Most chaplains reported being asked about post-mortem by parents, but only a minority felt adequately prepared.
JOURNAL OF RELIGION & HEALTH
(2021)