Article
Engineering, Biomedical
Yuriy Snyder, Soumen Jana
Summary: Valvular heart diseases are commonly treated using mechanical or bioprosthetic heart valves, but these valves have limitations. Heart valve tissue engineering offers a potential solution by using scaffolds that can grow with patients and function without the need for lifelong anticoagulation medication.
Article
Materials Science, Multidisciplinary
Tristan Mes, Aurelie Serrero, Hannah S. Bauer, Martijn A. J. Cox, Anton W. Bosman, Patricia Y. W. Dankers, E. W. Meijer
Summary: The main objective of Endogenous Tissue Restoration (ETR) is to restore the functional tissues in cardiovascular applications. The development of biocompatible, biodegradable, and tunable biomaterials has led to the progress in laboratory studies and clinical application of ETR. Supramolecular polymers, with the ability to control mechanical properties and biodegradability independently, offer unique advantages for ETR. This paper provides details on the mechanism of ETR and discusses the potential of supramolecular polymers in clinical applications.
Article
Cardiac & Cardiovascular Systems
Xi Lou, Yawen Tang, Lei Ye, Danielle Pretorius, Vladimir G. Fast, Asher M. Kahn-Krell, Jue Zhang, Jianhua Zhang, Aijun Qiao, Gangjian Qin, Timothy Kamp, James A. Thomson, Jianyi Zhang
Summary: The study demonstrates that human cardiac muscle patches containing three types of cardiac cells derived from human pluripotent stem cells significantly improved cardiac function, reduced infarct size, and promoted cardiac maturation in a pig model of myocardial infarction. The inclusion of cardiac fibroblasts in the cardiac patches enhanced the maturity and function of cardiac muscle cells. Transplantation of cardiac patches with cardiac fibroblasts resulted in better cardiac recovery and engraftment compared to patches without fibroblasts.
CARDIOVASCULAR RESEARCH
(2023)
Review
Materials Science, Multidisciplinary
Yuriy Snyder, Soumen Jana
Summary: Current clinical solutions for valvular heart diseases have limitations, but tissue engineering approach using heart valve scaffolds can provide a life-long solution.
PROGRESS IN MATERIALS SCIENCE
(2023)
Review
Materials Science, Paper & Wood
Walid Kamal Abdelbasset, Saud M. Alrawaili, Ahmed M. Osailan, Ahmed Abdelmoniem Ibrahim, Gaber S. Soliman, Ahmed M. Abodonya
Summary: Valvular heart disease presents a clinical challenge, and heart valve tissue engineering offers potential solutions. Polysaccharides as scaffolding biomaterials have widespread applications in HVTE.
Article
Cardiac & Cardiovascular Systems
Yuan-Tsan Tseng, Nabil F. Grace, Heba Aguib, Padmini Sarathchandra, Ann McCormack, Ahmed Ebeid, Nairouz Shehata, Mohamed Nagy, Hussam El-Nashar, Magdi H. Yacoub, Adrian Chester, Najma Latif
Summary: The study assessed the incorporation of carbon fibers into tissue-engineered heart valves for their cellular interaction and mechanical flexibility, finding that carbon fibers were conducive to stem cell attachment and maintaining their phenotype, as well as being sufficiently flexible for full motion of valvular opening and closure. This study provides a proof-of-concept for the incorporation of carbon fibers into tissue-engineered heart valves to continue their vital function during scaffold degradation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Materials Science, Multidisciplinary
Soumen Jana, Federico Franchi, Amir Lerman
Summary: The study developed trilayered microfibrous leaflet substrates using electrospinning to mimic native heart valve leaflets, which were implanted in rats to study their effect on in vivo tissue engineering. The resulting tissue constructs showed well-defined structure and anisotropic tensile properties suitable for withstanding physiological loads, indicating potential for heart valve replacements.
APPLIED MATERIALS TODAY
(2021)
Article
Chemistry, Multidisciplinary
Ying Zhou, Ge Yan, Shuyu Wen, Wai Yen Yim, Zihao Wang, Xing Chen, Yin Xu, Xue Chen, Hong Cao, Peng Bai, Fei Li, Jiawei Shi, Jianglin Wang, Weihua Qiao, Nianguo Dong
Summary: This study constructs a dual-functional TEHV scaffold by modifying DHV with copper ions (Cu) and growth differentiation factor 11 (GDF11), which improves hemocompatibility and accelerates endothelialization. The newly-constructed scaffold successfully generates endogenous nitric oxide (NO) and possesses improved hemocompatibility. Furthermore, GDF11 immobilization significantly accelerates scaffold endothelialization.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Diana Elena Ciolacu, Raluca Nicu, Florin Ciolacu
Summary: This review discusses the development and application of heart valve tissue engineering, with a focus on the recent achievements using natural polymers. It also examines the strategies for designing, validating, and remodeling heart valves.
Article
Materials Science, Multidisciplinary
Yuriy Snyder, Soumen Jana
Summary: Creating leaflet substrates that mimic the trilayered structure, anisotropic tensile characteristics, and elastomeric features of human heart valve leaflets is crucial to successful heart valve tissue engineering. In this study, elastomeric trilayer substrates made of a combination of polymers were developed to resemble native tissue. These substrates exhibited better cell adhesion, proliferation, extracellular matrix production, and resistance to calcification compared to non-elastomeric substrates.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Eva Jover, Marco Fagnano, William Cathery, Sadie Slater, Emanuela Pisanu, Yue Gu, Elisa Avolio, Domenico Bruno, Daniel Baz-Lopez, Ashton Faulkner, Michele Carrabba, Gianni Angelini, Paolo Madeddu
Summary: This study demonstrates that human adventitial pericytes (APCs) exhibit resistance to calcification compared to bone marrow-derived mesenchymal stromal cells (BM-MSCs) and convey the anti-calcific phenotype to heart valves through miR-132. These findings suggest that APCs may be a promising cell source for cellularization of prosthetic heart valves.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Engineering, Biomedical
Yuriy Snyder, Soumen Jana
Summary: This study investigated the influence of anisotropic structural and mechanical characteristics on cell behavior. Trilayer anisotropic fibrous substrates and randomly oriented isotropic fibrous substrates were created, and cells cultured on the trilayer substrates had higher proliferation, increased extracellular matrix production, and superior gene and protein expression compared to cells on random substrates. The different layers of the trilayer constructs also showed variations in gene expression. Overall, this study demonstrates the importance of substrate properties in tissue engineering.
BIO-DESIGN AND MANUFACTURING
(2023)
Article
Engineering, Biomedical
Guang Yang, Bhushan Mahadik, Ji Young Choi, Justine R. Yu, Trevor Mollot, Bin Jiang, Xiaoming He, John P. Fisher
Summary: The study utilized a microfluidic approach to prepare collagen microbeads loaded with human bone marrow derived mesenchymal stem cells for creating engineered bone grafts. The cell-laden microbeads self-assembled into macro-tissues, enabling precise control over cell spatial distribution at the macroscale, offering flexibility for graft volume and architecture. The approach has the potential to create 3D engineered bone grafts with customized vasculature using modular tissue engineering and 3D printing.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Ceramics
Jose Guilherme Neves, Daniel Navarro da Rocha, Camila Cristine Lopes, Rafael Maza Barbosa, Lorena Fernandes Ferreira, Cecilia Buzatto Westin, Angela Maria Moraes, Bruno Calsa, Milton Santamaria Jr, Lourenco Correr-Sobrinho, Americo Bortolazzo Correr
Summary: The aim of this study was to synthesize and characterize polymeric porous scaffolds associated with different calcium phosphates (CaP) and Mesenchymal Stem Cells (MSC) for regenerative dentistry application. The results showed that CaP improved the mechanical properties of scaffolds but decreased the cell viability. MSCs improved the inflammatory response after 60 days.
CERAMICS INTERNATIONAL
(2022)
Review
Chemistry, Physical
Vivian Alonso-Goulart, Loyna Nobile Carvalho, Ana Leticia Galante Marinho, Bianca Lourenco de Oliveira Souza, Gabriela de Aquino Pinto Palis, Henrique Guerra Drumond Lage, Isabela Lemos de Lima, Laura Duarte Guimaraes, Lucas Correia Peres, Marcia Marques Silveira, Gilberto Henrique Nogueira Lages Lopes, Lorraine Braga Ferreira, Leticia de Souza Castro-Filice
Summary: The use of biological templates for promoting the growth of AD-MSCs and new tissue construction has been rapidly increasing, with bioengineered scaffolds playing a crucial role in tissue regeneration. Biomaterials as the stem cell niche stimulate differentiation and affect immunomodulation through molecular signals. The analysis of 98 selected articles showed a high potential for clinical applications, with synthetic polymers being the most commonly used biomaterials, particularly in bone regeneration.
Article
Dermatology
Benedikt Weber, Chantal C. Bachmann, Ralph Braun, Alison G. Abraham, Andreas L. Serra, Gunther F. L. Hofbauer
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2017)
Article
Engineering, Biomedical
Agnieszka A. Ksiazek, Laura Frese, Petra E. Dijkman, Bart Sanders, Sarah E. Motta, Benedikt Weber, Simon P. Hoerstrup
ACTA BIOMATERIALIA
(2018)
Article
Engineering, Biomedical
Anna Mallone, Chantal Stenger, Arnold Von Eckardstein, Simon P. Hoerstrup, Benedikt Weber
Article
Cell Biology
Jaroslav Slamecka, Steven McClellan, Anna Wilk, Javier Laurini, Elizabeth Manci, Simon P. Hoerstrup, Benedikt Weber, Laurie Owen
Article
Anatomy & Morphology
Debora Kehl, Sabrina Goertz, Craig Wang, Simon P. Hoerstrup, Ulrich Bleul, Benedikt Weber
CELLS TISSUES ORGANS
(2018)
Article
Engineering, Biomedical
Melanie Generali, Elisa A. Casanova, Debora Kehl, Debora Wanner, Simon P. Hoerstrup, Paolo Cinelli, Benedikt Weber
ACTA BIOMATERIALIA
(2019)
Article
Cell & Tissue Engineering
Julia Deinsberger, David Reisinger, Benedikt Weber
NPJ REGENERATIVE MEDICINE
(2020)
Review
Dermatology
Georg Amun Hofmann, Benedikt Weber
Summary: Drug-induced photosensitivity, the development of phototoxic or photoallergic reactions due to pharmaceuticals and subsequent exposure to ultraviolet or visible light, is an adverse effect of growing interest. There are 393 different drugs reported to have a photosensitizing potential, with varying levels of evidence regarding their ability to induce photosensitive reactions. The epidemiological risk associated with the use of photosensitizers is difficult to assess.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Editorial Material
Dermatology
Simone Cazzaniga, Christina Wiedmer, Ziva Frangez, Maziar Shafighi, Helmut Beltraminelli, Benedikt Weber, Dagmar Simon, Luigi Naldi, Hans-Uwe Simon, Robert E. Hunger, S. Morteza Seyed Jafari
ACTA DERMATO-VENEREOLOGICA
(2020)
Article
Dermatology
Benedikt Weber, Sonja Radakovic, Adrian Tanew
EUROPEAN JOURNAL OF DERMATOLOGY
(2020)
Article
Cell & Tissue Engineering
Debora Kehl, Melanie Generali, Anna Mallone, Manfred Heller, Anne-Christine Uldry, Phil Cheng, Benjamin Gantenbein, Simon P. Hoerstrup, Benedikt Weber
NPJ REGENERATIVE MEDICINE
(2019)
Article
Biophysics
Melanie Generali, Debora Kehl, Andrew K. Capulli, Kevin K. Parker, Simon P. Hoerstrup, Benedikt Weber
COLLOIDS AND SURFACES B-BIOINTERFACES
(2017)
Article
Dermatology
A. D. Zimmer, G. J. Kim, A. Hotz, E. Bourrat, I. Hausser, C. Has, V. Oji, K. Stieler, A. Vahlquist, V. Kunde, B. Weber, F. P. W. Radner, S. Leclerc-Mercier, N. Schlipf, P. Demmer, J. Kuesel, J. Fischer
BRITISH JOURNAL OF DERMATOLOGY
(2017)
Article
Engineering, Biomedical
Andrew K. Capulli, Maximillian Y. Emmert, Francesco S. Pasqualini, Debora Kehl, Etem Caliskan, Johan U. Lind, Sean P. Sheehy, Sung Jin Park, Seungkuk Ahn, Benedikt Weber, Josue A. Goss, Simon P. Hoerstrup, Kevin Kit Parker
Article
Engineering, Biomedical
Maximilian Y. Emmert, Petra Wolint, Andras Jakab, Sean P. Sheehy, Francesco S. Pasqualini, Thi Dan Linh Nguyen, Monika Hilbe, Burkhardt Seifert, Benedikt Weber, Chad E. Brokopp, Dominika Macejovska, Etem Caliskan, Arnold von Eckardstein, Ruth Schwartlander, Viola Vogel, Volkmar Falk, Kevin Kit Parker, Mariann Gyoengyoesi, Simon P. Hoerstrup