Review
Cell Biology
Sabrina Ceeraz, Charlotte R. Thompson, Richard Beatson, Ernest H. Choy
Summary: T regulatory cell therapy offers a new approach for treating autoimmune diseases and transplantation. CD8(+) Treg cells, particularly the CD8(+)CD28(-) subset, have been shown to be effective in preclinical models, although their impaired functionality in disease limits their effectiveness in immunosuppression. The review focuses on harnessing CD8(+) Treg cell therapy in clinical settings to aid current treatments for autoimmune and inflammatory conditions.
Review
Immunology
Jing Lu, Taotao Liang, Ping Li, Qingsong Yin
Summary: The tumor microenvironment (TME) plays a crucial role in various aspects of tumor progression and clinical outcomes. Understanding the status of TME, the involvement of immune cells, and the key factors driving T cell dysfunction is essential for developing effective therapies. This study focuses on the regulatory effects of Interferon regulatory factor 4 (IRF4) on immune cells in the TME and highlights its potential as a therapeutic target for reversing T cell exhaustion and promoting anti-tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Saeed Daneshmandi, Teresa Cassel, Richard M. Higashi, Teresa W-M Fan, Pankaj Seth
Summary: This study revealed the critical role of 6PGD in regulating Tregs function and cell plasticity, providing a new metabolic checkpoint for immunotherapy applications.
Review
Immunology
Ilse Gille, Frans H. J. Claas, Geert W. Haasnoot, Mirjam H. M. Heemskerk, Sebastiaan Heidt
Summary: Solid organ transplantation is an effective treatment for end-stage diseases, but the need for immunosuppression can lead to serious side effects. CAR Treg therapy, specifically with HLA-A2 CAR Tregs, shows potential in promoting transplantation tolerance and improving graft survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jia Wang, Sheng-Xiao Zhang, Jia-Song Chang, Ting Cheng, Xiao-Jing Jiang, Qin-Yi Su, Jia-Qi Zhang, Jing Luo, Xiao-Feng Li
Summary: This study investigated the status of CD4(+) Tregs and the effects of low-dose IL-2 therapy in patients with refractory rheumatoid arthritis (RA). The results showed that a decrease in the absolute number of CD4 Tregs, rather than an increase in Th17 cells, contributed to an imbalance and high disease activity. Low-dose IL-2 selectively increased CD4 Tregs and rebalanced the ratio of Th17 and CD4 Tregs, leading to symptom remission without side effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Vasti Lozano-Ordaz, Yadira Rodriguez-Miguez, Angel E. Ortiz-Cabrera, Sujhey Hernandez-Bazan, Dulce Mata-Espinosa, Jorge Barrios-Payan, Rafael Saavedra, Rogelio Hernandez-Pando
Summary: This study compared the contribution of Treg cells, IDO, and HO-1 in mice infected with Mtb strains of different virulences. It found that these factors were detrimental for immune protection in mild virulence infection, but beneficial in highly virulent infection by regulating excessive inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Jeffrey Y. W. Mak, Ligong Liu, David P. Fairlie
Summary: Researchers have made significant contributions in the field of microbial natural products and synthetic ligands over the past decade, particularly focusing on compounds related to riboflavin and uracils that modulate immune cells. Through collaboration, they discovered a naturally occurring compound synthesized by bacteria that activates MAIT cells, leading to its use in detecting and characterizing MAIT cells in tissues.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Review
Cell Biology
Norberto W. Zwirner, Carolina I. Domaica, Mercedes B. Fuertes
Summary: NK cells can kill target cells through perforin-dependent mechanisms or apoptosis, and secrete cytokines important for immunomodulation. In addition to their role in tumor and virus-infected cell immunity, NK cells have been implicated in regulating T cell responses in autoimmunity, transplantation, and viral infection models.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Review
Immunology
Qi-Ming Pang, Si-Yu Chen, Sheng-Ping Fu, Hui Zhou, Qian Zhang, Jun Ao, Xiao-Ping Luo, Tao Zhang
Summary: This review focuses on the immunoregulatory capacity of mesenchymal stem cells (MSCs) in spinal cord injury (SCI) and their potential in tissue repair. The inflammatory cascade plays a crucial role in the secondary injury of SCI, and transplanting MSCs can regulate various immune cells to create a favorable microenvironment for neurological function recovery.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Emma T. M. Peereboom, Benedict M. Matern, Toshihide Tomosugi, Matthias Niemann, Julia Drylewicz, Irma Joosten, Wil A. Allebes, Arnold van der Meer, Luuk B. Hilbrands, Marije C. Baas, Franka E. van Reekum, Marianne C. Verhaar, Elena G. Kamburova, Marc A. J. Seelen, Jan Stephan Sanders, Bouke G. Hepkema, Annechien J. Lambeck, Laura B. Bungener, Caroline Roozendaal, Marcel G. J. Tilanus, Christien E. Voorter, Lotte Wieten, Elly M. van Duijnhoven, Marielle A. C. J. Gelens, Maarten H. L. Christiaans, Frans J. van Ittersum, Azam Nurmohamed, Neubury M. Lardy, Wendy Swelsen, Karlijn A. van der Pant, Neelke C. van der Weerd, Ineke J. M. ten Berge, Frederike J. Bemelman, Aiko P. J. de Vries, Johan W. de Fijter, Michiel G. H. Betjes, Dave L. Roelen, Frans H. Claas, Henny G. Otten, Sebastiaan Heidt, Arjan D. van Zuilen, Takaaki Kobayashi, Kirsten Geneugelijk, Eric Spierings
Summary: The presence of pre-transplant donor-reactive CD4(+) memory T-helper cells may increase the risk of graft failure following kidney transplantation, as shown by the significant association between Shared T-cell EPitopes (STEP) score and the 10-year risk of death-censored kidney graft failure.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Miao Wang, Angus W. Thomson, Fang Yu, Rimi Hazra, Aditi Junagade, Xiaoming Hu
Summary: Regulatory T cells play a crucial role in regulating immune responses and promoting brain recovery after stroke. Through cell-cell interactions and soluble factor release, they have diverse beneficial effects on brain protection and repair.
SEMINARS IN IMMUNOPATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Monique Costa, Valeria da Costa, Sofia Frigerio, Maria Florencia Festari, Mercedes Landeira, Santiago A. Rodriguez-Zraquia, Pablo Lores, Paula Carasi, Teresa Freire
Summary: This study revealed the regulatory role of HO-1 induced by F. hepatica and its immunoregulatory and antioxidant effects in fasciolosis. Through the activity of IL-10, Tregs and APC expressing HO-1 in mice were controlled during parasite infection. Further experiments showed that IL-10R neutralization and the use of HO-1 inhibitors protected mice from parasite infection.
Article
Oncology
Catherine M. Ade, Matthew J. Sporn, Sudipto Das, Zhiya Yu, Ken-ichi Hanada, Yue A. Qi, Tapan Maity, Xu Zhang, Udayan Guha, Thorkell Andresson, James C. Yang
Summary: This article introduces a method of using mass spectrometry to identify common tumor-specific neoepitopes derived from mutated oncogenes, and develop TCRs based on these data. The results of the study show that this method successfully identified precise neoepitopes derived from KRAS, EGFR, BRAF, and PIK3CA presented by HLA-A*03:01 and/or HLA-A*11:01 across multiple biological replicates.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Engineering, Multidisciplinary
Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa
Summary: Chimeric antigen receptors (CARs) are a breakthrough in genetic engineering that redirect cells to specific targets. They have been shown to improve accuracy, potency, and reduce off-target effects in cancer therapy. Regulatory T cells (Tregs) are important in suppressing immune activation and regulating the immune response. CAR-Tregs hold potential for treating autoimmune diseases, GVHD, and organ transplant rejection.
Article
Medicine, Research & Experimental
Ella S. Green, Lachlan M. Moldenhauer, Holly M. Groome, David J. Sharkey, Peck Y. Chin, Alison S. Care, Rebecca L. Robker, Shaun R. McColl, Sarah A. Robertson
Summary: Using a mouse model, this study found that regulatory T cells (Treg cells) play a crucial role in mediating the effects of progesterone on uterine receptivity by repairing blood vessel remodeling and placental structure, and restoring T cell imbalance in the mother, thereby alleviating fetal loss and growth restriction caused by reduced progesterone signaling.