Article
Cell Biology
Mo Li, Xin Shen, Hui Liu, Bei Yang, Siying Lu, Min Tang, Yan Ling, Yuezhen Li, Haibin Kuang
Summary: Recent studies have shown that NTE plays a crucial role in normal placental and blood vessel development, but its involvement in abnormal placental angiogenesis of pre-eclampsia remains unclear. The study found that reduced NTE levels in pre-eclamptic placentas had significant effects on the migration and tube formation of HUVECs. Furthermore, dysregulation of PC and LPC metabolism due to altered NTE expression may contribute to abnormal placental angiogenesis in pre-eclampsia.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Hematology
Viktoria Bitsadze, Sylvie Bouvier, Jamilya Khizroeva, Eva Cochery-Nouvellon, Eric Mercier, Antonia Perez-Martin, Alexander Makatsariya, Jean-Christophe Gris
Summary: This study found that ADAMTS13 activity, antibodies, and antigen levels in newly pregnant women with obstetric antiphospholipid syndrome (oAPS) are associated with the occurrence of pre-eclampsia (PEcl). These markers serve as significant risk factors for PEcl and its subgroups, exhibiting acceptable discrimination power in predicting clinical events. ADAMTS13 may help identify pregnant women with oAPS who do not require escalated treatment strategies to prevent PEcl.
THROMBOSIS RESEARCH
(2021)
Article
Immunology
Chiara Tersigni, Donatella Lucchetti, Rita Franco, Filomena Colella, Caterina Neri, Laura Crispino, Alessandro Sgambato, Antonio Lanzone, Giovanni Scambia, Manu Vatish, Nicoletta Di Simone
Summary: PE is a common pregnancy disorder characterized by hypertension and proteinuria, with aberrant expression of HLA-DR in STBEVs specifically associated with PE. Further studies are needed to define the role of abnormal placental HLA-DR expression in PE pathogenesis and evaluate the potential application of detecting circulating HLA-DR positive STBEVs in diagnosing and predicting PE in early and mid-pregnancy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Hikari Yoshizawa, Haruki Nishizawa, Hidehito Inagaki, Keisuke Hitachi, Akiko Ohwaki, Yoshiko Sakabe, Mayuko Ito, Kunihiro Tsuchida, Takao Sekiya, Takuma Fujii, Hiroki Kurahashi
Summary: A long non-coding RNA gene called MG828507 was found to be overexpressed in pre-eclamptic placentas, and it is located in the same genomic region as the FLT1 gene. While overexpression or knockdown of MG828507 did not affect FLT1 expression, the transcript level of MG828507 was associated with genetic variants linked to pre-eclampsia and correlated with birth weight and placental weight.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sammy Hermans, Jacob Pilon, Dennis Eschweiler, Johannes Stegmaier, Carmen A. H. Severens-Rijvers, Salwan Al-Nasiry, Marc van Zandvoort, Dimitrios Kapsokalyvas
Summary: Pre-eclampsia is a severe complication in pregnancy with limited diagnostic and therapeutic options, and there is controversy surrounding its etiology and phenotypes. Using multiphoton microscopy (MPM) imaging, the native placental three-dimensional morphology can be visualized with subcellular resolution, allowing for the identification of various imaging targets such as trophoblast organization, villous tree structure, syncytial knots, fibrosis, and vascular networks. Preliminary data suggests that pre-eclampsia is characterized by increased syncytial knot density, paddle-like villous sprouts, abnormal villous volume-to-surface ratio, and decreased vascular density. Quantifying 3D microscopic images shows potential for phenotyping pre-eclampsia in placental villous tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ilona Jaszczuk, Izabela Winkler, Dorota Koczkodaj, Maciej Skrzypczak, Agata Filip
Summary: This review article analyzes the role of C19MC miRNA in the development of pre-eclampsia and summarizes the current research data. The results indicate that C19MC miRNAs are significantly upregulated in placental tissue of pre-eclampsia patients and can be detected in high levels in the blood. Among them, miR-525-5p shows low expression in the plasma of the first trimester. By identifying these miRNAs, it may be possible to predict the development of pre-eclampsia before the onset of clinical symptoms, thereby avoiding serious complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Nir Melamed, Nanette Okun, Tianhua Huang, Elad Mei-Dan, Amir Aviram, Melinda Allen, Kasim E. Abdulaziz, Sarah D. McDonald, Beth Murray-Davis, Joel G. Ray, Jon Barrett, John Kingdom, Howard Berger
Summary: Unlike second-trimester AFP, elevated first-trimester AFP is not an independent risk factor for placenta-mediated complications.
Article
Veterinary Sciences
Angelika Brzozowska, Tomasz Stankiewicz, Barbara Blaszczyk, Pavitra Chundekkad, Jan Udala, Natalia Wojtasiak
Summary: The study found that the position of arterial vessels in the placental-umbilical circulation and the gestational age significantly impact hemodynamic parameters. The research provides new insights on the blood flow in caruncular and cotyledonary arteries in sheep, contributing to a better understanding of hemodynamic changes in sheep placentas. Preliminary studies on analyzing hemodynamic parameters in umbilical and placental veins in sheep are promising for future research in this field. Moreover, the practicality of transrectal ultrasonography in early pregnancy diagnosis in sheep, as well as the use of B-mode ultrasonography for identifying corpus luteum to confirm effective mating, has been confirmed.
BMC VETERINARY RESEARCH
(2022)
Article
Immunology
Jessica Schuster, Shi-Bin Cheng, James Padbury, Surendra Sharma
Summary: Pre-eclampsia is a hypertensive disease of pregnancy with mechanisms centered around abnormal placentation, inadequate spiral-artery remodeling, and deficiency in trophoblast invasion. Extracellular vesicles (EVs) are suggested to play a crucial role in pre-eclampsia, potentially influencing immune responses, inflammation, altered angiogenesis, and endothelial dysfunction.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Acoustics
C. Ebbing, S. Rasmussen, J. Kessler, D. Moster
Summary: This study found that abnormalities of the umbilical cord or placenta are associated with cerebral palsy (CP), regardless of gestational age or sex of the child.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Developmental Biology
J. F. Briffa, W. Bevens, S. Gravina, J. M. Said, M. E. Wlodek
Summary: This study demonstrates that complete knockout of biglycan is not associated with features of pre-eclampsia.
Article
Pharmacology & Pharmacy
Michelle Broekhuizen, Rene de Vries, Marja A. W. Smits, Willem A. Dik, Sam Schoenmakers, Birgit C. P. Koch, Daphne Merkus, Irwin K. M. Reiss, A. H. Jan Danser, Sinno H. P. Simons, Emilie Hitzerd
Summary: This study investigated the placental transfer, vascular effects, and anti-inflammatory actions of pentoxifylline in healthy and pre-eclamptic human placentas. The results showed that while pentoxifylline had beneficial effects on vasodilation and inflammation in healthy placentas, these effects were not retained in pre-eclamptic placentas. This limits the application of pentoxifylline in the treatment of pre-eclampsia, but it may still have value for other placenta-related disorders.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiaoli Shen, Christian De Geyter, Hong Zhang, Guoning Huang
Summary: Proper placental development and function are crucial for the health of both the mother and the fetus during pregnancy. JMJD6, along with other angiogenic factors, plays a significant role in regulating placental angiogenesis. Understanding the interaction between JMJD6 and other placental factors may identify potential therapeutic targets for correcting abnormal placental angiogenesis and function.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Article
Developmental Biology
L. Larcher, E. Jauniaux, J. Lenzi, R. Ragnedda, D. Morano, M. Valeriani, G. Michelli, A. Farina, E. Contro
Summary: In this prospective cohort study, we found that placental and umbilical cord anomalies are more common in IVF singleton pregnancies compared to spontaneous pregnancies. We also identified oocyte donor fertilization as an additional risk factor for the development of these anomalies. Ultrasound examinations play a crucial role in screening for these anomalies.
Review
Biochemistry & Molecular Biology
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Grazia Fenu, Manal Fardoun, Rabah Iratni, Ali H. Eid, Hatem Zayed, Gianfranco Pintus
Summary: Adverse pregnancy outcomes have significant health risks for pregnant women and their offspring. Maternal dietary intake of polyphenolic antioxidants, such as resveratrol, is linked to a reduced risk of maternal obesity and cardio-metabolic disorders, positively affecting both the fetus and offspring.
