Article
Endocrinology & Metabolism
Thierry Brue, Philippe Chanson, Patrice Rodien, Brigitte Delemer, Delphine Drui, Lucile Marie, Laurene Juban, Lara Salvi, Robin Henocque, Gerald Raverot
Summary: The study aimed to estimate the cost-utility of second-line pharmacological treatments in acromegaly patients.
The incremental cost-utility ratios for pasireotide, pegvisomant, and pegvisomant + FGSA were estimated, showing pasireotide to be the least cost-efficient treatment option.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Meng-Ting Li, Long Xie, Hai-Mei Jiang, Qun Huang, Rong-Sheng Tong, Xiang Li, Xin Xie, Hong-Mei Liu
Summary: This review provides a comprehensive update on the pharmacology of Licochalcone A (LA) over the past decade. LA has been found to possess multiple pharmacological properties and acts through various signaling pathways. Recent studies have primarily focused on the anticancer properties of LA, highlighting the need for further research on other aspects of its pharmacology. The review is divided into three parts based on the pharmacological effects of LA, providing insights for future research.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Bernard Gallez
Summary: Hypoxia is a common feature of solid tumors and plays a role in tumor progression and resistance to therapy. Despite various approaches to target hypoxia, their translation into clinical practice has been disappointing. Companion diagnostics may help in matching patients with specific interventions.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Ilgiz Gareev, Ozal Beylerli, Yanchao Liang, Huang Xiang, Chunyang Liu, Xun Xu, Chao Yuan, Aamir Ahmad, Guang Yang
Summary: Brain tumors, such as glioblastoma, are challenging to treat and have poor outcomes. Research on the role of miRNAs in the pathogenesis of brain tumors and their impact on treatment resistance is crucial for addressing this major clinical challenge.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Michal Elbaum, Marcin Kaluzny, Aleksandra Jawiarczyk-Przybylowska, Beata Wojtczak, Grzegorz Zielinski, Marek Bolanowski
Summary: Uncontrolled acromegaly is associated with increased morbidity and mortality. The incidence of comorbidities and complications in acromegaly patients is high, with the most common being arterial hypertension, multinodular goiter, lipid disorders, hypopituitarism, and degenerative changes. Active acromegaly has a higher incidence of complications compared to treated groups. Successfully cured patients have significantly fewer complications than pharmacologically controlled patients and patients with active acromegaly.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Leticia P. Leonart, Bruno S. Riveros, Murray D. Krahn, Roberto Pontarolo
Summary: The study compared cost-utility analysis of drug strategies for acromegaly in Brazil, with lanreotide showing the most cost-effective results. Future research should focus on acquiring utility data to reduce uncertainty in decision-making.
NEUROENDOCRINOLOGY
(2021)
Review
Neurosciences
Emir Licina, Aleksandra Radojicic, Marta Jeremic, Aleksandra Tomic, Milija Mijajlovic
Summary: Headache disorders have a significant impact on global health, leading to a decline in quality of life. While there are numerous pharmacological treatments available, some patients may experience adverse effects or insufficient efficacy, necessitating the exploration of alternative treatment strategies. This review briefly explains and evaluates established and emerging non-pharmacological approaches for headache management, with a focus on nutraceuticals and diet, acupuncture, cognitive behavioral therapy (CBT), biofeedback, relaxation techniques, autogenic training, and neuromodulation. Psychological interventions deserve special attention as they enhance patient self-efficacy and provide strategies for managing chronic pain. Future research should aim to optimize these therapies, identify patient-specific factors influencing their effectiveness, and integrate them into comprehensive headache management strategies.
Article
Endocrinology & Metabolism
Paula P. B. Silva, Rosa M. R. Pereira, Liliam Takayama, Clarissa G. Borba, Felipe H. Duarte, Ericka B. Trarbach, Regina Matsunaga Martin, Marcello D. Bronstein, Nicholas A. Tritos, Raquel S. Jallad
Summary: The study evaluated the impact of isolated GH/IGF-I hypersecretion on bone turnover markers, microarchitecture, and vertebral fractures in female patients with acromegaly. Results showed increased cortical BMD, impaired trabecular bone microstructure, and increased VF in acromegaly patients. Sclerostin was not correlated with HR-pQCT parameters, while DKK1 was correlated with cortical porosity in the tibia. Additional studies are needed to clarify the role of Wnt inhibitors on bone microarchitecture impairment in acromegaly.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Annarosa Floreani, Daniela Gabbia, Sara De Martin
Summary: Ursodeoxycholic acid is the first-line therapy for PBC, but new pharmacological agents are being proposed for UDCA-non-responders. Obeticholic acid and fibrates have shown effectiveness in improving biochemistry alteration and symptoms of PBC. Other new agents with different mechanisms of action are also under clinical evaluation for PBC treatment.
Article
Endocrinology & Metabolism
Paula P. B. Silva, Rosa M. R. Pereira, Liliam Takayama, Clarissa G. Borba, Felipe H. Duarte, Ericka B. Trarbach, Regina Matsunaga Martin, Marcello D. Bronstein, Nicholas A. Tritos, Raquel S. Jallad
Summary: Acromegaly patients show abnormalities in bone microstructure, bone density, and vertebral fractures, with significant differences in sclerostin and DKK1 compared to the healthy control group, indicating a potential role of Wnt inhibitors in bone microstructure impairment in acromegaly.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Medicine, General & Internal
Syeda T. Rizvi, Jhankhana S. Shah, Sarah Shaaya, Tatyana Mollayeva
Summary: This research examines the use of pharmacotherapy in reducing cognitive impairments in adult patients with primary CNS infections. The results show inconsistent effects of drug treatment on cognitive domains in patients with LD, HSV-1, and CJD, with low certainty in the evidence.
Review
Physiology
Anna Langner-Hetmanczuk, Stanislaw Tubek, Piotr Niewinski, Piotr Ponikowski
Summary: Peripheral chemoreceptors play a crucial role in sensing hypoxia in mammals and adapting to oxygen-deficient conditions. However, chronic overstimulation of these receptors can lead to the progression of sympathetically-mediated diseases. Therefore, deactivating peripheral chemoreceptors has been proposed as a treatment method for these disorders. This review article provides an overview of the physiological background and current understanding of the effects of commonly prescribed medications on the acute and tonic activities of peripheral chemoreceptors.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Pamela U. Freda
Summary: Acromegaly is a hormonal disorder characterized by excess hormone production, leading to a specific lipodystrophy and insulin resistance. Understanding the pathophysiology of this condition and its effects on adipose tissue metabolism and insulin resistance is important for optimizing treatment and long-term outcomes for patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Juan Du, Amanda N. Pope, Brianne R. O'Leary, Brett A. Wagner, Prabhat C. Goswami, Garry R. Buettner, Joseph J. Cullen
Summary: At pharmacological levels, ascorbate acts as a pro-oxidant and induces cell death. This study investigated the role of ATP production by oxidative phosphorylation or glycolysis in resistance to ascorbate-induced cell death.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Eva K. Egger, Mateja Condic, Damian J. Ralser, Milka Marinova, Alexander Mustea, Florian Recker, Glen Kristiansen, Thore Thiesler
Summary: Vaginal cancer lacks practical guidelines and data on systemic therapies due to its rarity. This study aimed to assess clinical and pathological factors, as well as treatment outcomes, of vaginal cancer patients. The study found that age, nodal metastasis, lymphangiosis, and hemangiosis had significant impacts on survival, while P16 expression showed improved survival rates. Use of anti-VEGF and immunotherapy showed promise in long-term survivors with recurrent vaginal cancer.