Article
Clinical Neurology
Josh Ma, Peter Gooderham, Ryojo Akagami, Serge Makarenko
Summary: Postoperative diabetes insipidus (DI) after pituitary adenoma resection is correlated with the degree of pituitary gland descent. By quantifying the descent and tension on the pituitary stalk, we can predict the occurrence of postoperative DI.
Review
Endocrinology & Metabolism
Xiaohai Liu, Renzhi Wang, Mingchu Li, Ge Chen
Summary: Pituitary metastasis is a rare condition, but its incidence increases with age. Breast cancer in women and lung cancer in men are the most frequent primary origins. Misdiagnosing pituitary metastasis as primary pituitary adenoma can be challenging. This case report emphasizes the importance of differential diagnosis of invasive sellar region lesions, especially in individuals over 60 with diabetes insipidus.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Hiroshi Arima, Timothy Cheetham, Mirjam Christ-Crain, Deborah Cooper, Juliana Drummond, Mark Gurnell, Miles Levy, Ann McCormack, John Newell-Price, Joseph G. Verbalis, John Wass, John Wass
Summary: Recent data suggests that patients with diabetes insipidus (DI) are being harmed. The authors propose renaming central and nephrogenic DI as arginine vasopressin deficiency and resistance, respectively.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
M. Araujo-Castro, F. Marino-Sanchez, A. Acitores Cancela, A. Garcia Fernandez, S. Garcia Duque, V. Rodriguez Berrocal
Summary: In patients undergoing endoscopic endonasal transsphenoidal surgery, those younger than 65 years, with diaphragm opening during pituitary surgery, and with total tumor resection are at higher risk of developing diabetes insipidus. Increasing craniocaudal diameter of pituitary adenoma is associated with an increased risk of permanent diabetes insipidus.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Review
Oncology
Agnese Barnabei, Lidia Strigari, Andrea Corsello, Rosa Maria Paragliola, Luca Falzone, Roberto Salvatori, Salvatore Maria Corsello, Francesco Torino
Summary: Immune checkpoint inhibitors may cause central diabetes insipidus, but there are inconsistencies and a lack of specific guidelines in its diagnosis and management. Endocrinological consultation can assist medical oncologists in treating this side effect, but they are still responsible for early diagnosis and drug management.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Andrea Ghezzi, Jessica Rossi, Francesco Cavallieri, Manuela Napoli, Rosario Pascarella, Romana Rizzi, Marco Russo, Gaetano Salomone, Antonio Romano, Corrado Iaccarino, Elisabetta Froio, Silvia Serra, Salvatore Cozzi, Lucia Giaccherini, Franco Valzania, Anna Pisanello
Summary: A rare case of pituitary metastasis from gastric cardia adenocarcinoma is reported in this article. The patient presented with symptoms of diabetes insipidus and visual deterioration. Surgical removal of the pituitary mass revealed adenocarcinoma of uncertain origin. This case highlights the importance of considering pituitary metastasis as a potential cause for diabetes insipidus and visual impairment, especially without evidence of other metastatic sites.
FRONTIERS IN ONCOLOGY
(2023)
Review
Endocrinology & Metabolism
Ugur Ture, Annamaria De Bellis, Mehmet Volkan Harput, Giuseppe Bellastella, Melih Topcuoglu, Cumhur Kaan Yaltirik, Paolo Cirillo, Rima Nur Yola, Aydin Sav, Fahrettin Kelestimur
Summary: The case study describes a 35-year-old female with autoimmune hypothalitis, presenting with central diabetes insipidus, partial empty sella, hypopituitarism, and hyperprolactinemia. Immunohistochemical examination of the surgically removed suprasellar mass confirmed autoimmune involvement, with the presence of antihypothalamus antibodies and high AVPcAb titers, suggesting isolated hypothalamitis. This observation suggests hypothalamitis as a new isolated autoimmune disease involving the hypothalamus, with potential consequences such as lymphocytic infundibuloneurohypophysitis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Clinical Neurology
Elena L. Sorba, Victor E. Staartjes, Stefanos Voglis, Lazar Tosic, Giovanna Brandi, Oliver Tschopp, Carlo Serra, Luca Regli
Summary: Electrolyte disorders, particularly DI and SIADH, are common complications after pituitary surgery, with younger age and lower preoperative serum sodium identified as significant predictors for postoperative SIADH. Further research is needed for early detection and prevention of these disorders.
NEUROSURGICAL REVIEW
(2021)
Article
Clinical Neurology
Rushikesh S. Joshi, Matheus P. Pereira, Robert C. Osorio, Taemin Oh, Alexander F. Haddad, Kaitlyn M. Pereira, Kevin C. Donohue, Zain Peeran, Sweta Sudhir, Saket Jain, Angad Beniwal, Ankush Chandra, Seunggu J. Han, John D. Rolston, Philip V. Theodosopoulos, Sandeep Kunwar, Lewis S. Blevins Jr, Manish K. Aghi
Summary: In this study, the occurrence of diabetes insipidus (DI) following pituitary surgery was found to be 10.7%. Factors such as younger age, intraoperative cerebrospinal fluid (CSF) encounter, craniopharyngioma diagnosis, and postoperative hyponatremia were associated with increased risk of DI. Patients with DI also experienced peak sodium levels later than those without DI.
JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Hiroaki Hashimoto, Tomoyuki Maruo, Masami Nakamura, Yukitaka Ushio, Masayuki Hirata, Haruhiko Kishima
Summary: This case report highlights the importance of considering pituitary dysfunction, including masked diabetes insipidus, in patients with pituitary metastases. The case also suggests that invasive interventions, such as biopsies, can induce pituitary dysfunction even in asymptomatic patients.
JOURNAL OF MEDICAL CASE REPORTS
(2022)
Article
Endocrinology & Metabolism
Hussam Rostom, Sean Noronha, Bahram Jafar-Mohammadi, Christine May, Anouk Borg, Jane Halliday, Simon Cudlip, Tim James, Nishan Guha, Brian Shine, Aparna Pal
Summary: Copeptin analysis is a useful tool in predicting the risk of developing DI after trans-sphenoidal surgery. Patients with plasma copeptin levels greater than 3.4 pmol/l at day 1 post-operation have a high sensitivity in ruling out DI, potentially leading to earlier decision making and shorter hospital stays.
Article
Medicine, Research & Experimental
Kunzhe Lin, Kaichun Fan, Shuwen Mu, Shousen Wang
Summary: This study aimed to evaluate the factors contributing to the development of diabetes insipidus after transsphenoidal surgery for pituitary adenomas. The change in cephalocaudal tumor cavity diameter was found to be associated with the occurrence of postoperative diabetes insipidus.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Pediatrics
Mizuki Tani, Shota Hiroshima, Hidetoshi Sato, Kentaro Sawano, Yohei Ogawa, Masaru Imamura, Makoto Oishi, Keisuke Nagasaki
Summary: Central diabetes insipidus (CDI) is a rare disease in children with various causes. Pituitary stalk thickening (PST) can be caused by germinoma, Langerhans cell histiocytosis (LCH), and lymphocytic infundibulo-neurohypophysitis, which require pathological diagnosis. We report a case of infantile-onset isolated neurohypophyseal LCH diagnosed by pathological findings, and discuss the treatment and prognosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Adam Orr, Chi Braunreiter, Christel Keefe, Matthew Christy, Bradford W. Betz
Summary: A sellar spine is a midline bony spur arising from the ventral aspect of the dorsum sellae, often considered clinically insignificant. Recent research suggests a potential association between sellar spine and pediatric pituitary endocrinopathies, possibly due to deformation of the developing pituitary gland caused by the sellar spine.
Article
Oncology
Nicholas G. Zaorsky, Xi Wang, Sara M. Garrett, Eric J. Lehrer, Christine Lin, David J. DeGraff, Daniel E. Spratt, Daniel M. Trifiletti, Amar U. Kishan, Timothy N. Showalter, Henry S. Park, Jonathan T. Yang, Vernon M. Chinchilli, Ming Wang
Summary: This project aimed to redefine staging of metastatic cancer, identified five metastatic phenotypes through latent class analysis, and found long-term survivors. All metastatic cancer is considered as Stage IV disease.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biophysics
Mouhamed Yazan Abou-Ismail, Gayathri Ravi, Pingfu Fu, Shufen Cao, Sowjanya Vuyyala, Paolo Caimi, Merle Kolk, Nicole Ferrari, Kirsten Boughan, Brenda Cooper, Molly Gallogly, Folashade Otegbeye, Benjamin Tomlinson, Marcos de Lima, Leland Metheny
Summary: Allogeneic hematopoietic cell transplant is an effective treatment for blood diseases, but drug use may lead to adverse outcomes. A retrospective analysis of 232 patients found that drug use was associated with increased non-relapse mortality, suggesting further research with larger cohorts is needed to validate these findings.
BONE MARROW TRANSPLANTATION
(2021)
Correction
Biophysics
Mouhamed Yazan Abou-Ismail, Gayathri Ravi, Pingfu Fu, Shufen Cao, Sowjanya Vuyyala, Paolo Caimi, Merle Kolk, Nicole Ferrari, Kirsten Boughan, Brenda Cooper, Molly Gallogly, Folashade Otegbeye, Benjamin Tomlinson, Marcos de Lima, Leland Metheny
Summary: An amendment to this paper has been published and is accessible via a link at the top of the paper.
BONE MARROW TRANSPLANTATION
(2021)
Article
Oncology
Kamal Chamoun, Amin Firoozmand, Paolo Caimi, Pingfu Fu, Shufen Cao, Folashade Otegbeye, Leland Metheny, Seema Patel, Stanton L. Gerson, Kirsten Boughan, Marcos De Lima, Ehsan Malek
Summary: Multiple Myeloma patients have seen improved outcomes with the introduction of novel medications and autologous hematopoietic cell transplantation. However, economic factors and treatment facility type play an important role in their survival.
Article
Medicine, Research & Experimental
Can F. Koyuncu, Cheng Lu, Kaustav Bera, Zelin Zhang, Jun Xu, Paula Toro, German Corredor, Deborah Chute, Pingfu Fu, Wade L. Thorstad, Farhoud Faraji, Justin A. Bishop, Mitra Mehrad, Patricia D. Castro, Andrew G. Sikora, Lester D. R. Thompson, R. D. Chernock, Krystle A. Lang Kuhs, Jingqin Luo, Vlad Sandulache, David J. Adelstein, Shlomo Koyfman, James S. Lewis, Anant Madabhushi
Summary: MuNI is a deep-learning-based metric for prognostication in p16* OPSCC, quantifying tumor multinucleation from digitally scanned H & E-stained slides. It independently predicts treatment failure in patients with p16* OPSCC and shows promise as a low-cost digital biomarker test for counseling, treatment, and surveillance.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Patrick Leo, Andrew Janowczyk, Robin Elliott, Nafiseh Janaki, Kaustav Bera, Rakesh Shiradkar, Xavier Farre, Pingfu Fu, Ayah El-Fahmawi, Mohammed Shahait, Jessica Kim, David Lee, Kosj Yamoah, Timothy R. Rebbeck, Francesca Khani, Brian D. Robinson, Lauri Eklund, Ivan Jambor, Harri Merisaari, Otto Ettala, Pekka Taimen, Hannu J. Aronen, Peter J. Bostrom, Ashutosh Tewari, Cristina Magi-Galluzzi, Eric Klein, Andrei Purysko, Natalie NC Shih, Michael Feldman, Sanjay Gupta, Priti Lal, Anant Madabhushi
Summary: Histotyping is an automated BCR prognosis method that is tissue non-destructive and utilizes computational image analysis of morphologic patterns in prostate tissue. Through training and validation on a large number of patients, Histotyping demonstrates good prognostic performance in various clinically stratified subsets, independently of other clinical parameters. Its performance outperforms Decipher in predicting post-RP BCR.
NPJ PRECISION ONCOLOGY
(2021)
Article
Oncology
Yishan Yu, Pingfu Fu, Jian-Yue Jin, Siming Gao, Weili Wang, Mitchell Machtay, Linlin Wang, Feng-Ming (Spring) Kong, Jinming Yu
Summary: This study validated the significant impact of Effective Dose to Immune Cell (EDIC) on overall survival (OS) in limited-stage small cell lung cancer (LS-SCLC) patients. Specifically, EDIC plays an important predictive role in lymphocyte nadir, progression free survival (PFS) and OS in LS-SCLC.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
German Corredor, Paula Toro, Can Koyuncu, Cheng Lu, Christina Buzzy, Kaustav Bera, Pingfu Fu, Mitra Mehrad, Kim A. Ely, Mojgan Mokhtari, Kailin Yang, Deborah Chute, David J. Adelstein, Lester D. R. Thompson, Justin A. Bishop, Farhoud Faraji, Wade Thorstad, Patricia Castro, Vlad Sandulache, Shlomo A. Koyfman, James S. Lewis, Anant Madabhushi
Summary: This study investigates whether OP-TIL, a biomarker, can separate stage I HPV-associated OPSCC patients into low-risk and high-risk groups and aid in patient selection for de-escalation clinical trials.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Multidisciplinary Sciences
Xiangxue Wang, Cristian Barrera, Kaustav Bera, Vidya Sankar Viswanathan, Sepideh Azarianpour-Esfahani, Can Koyuncu, Priya Velu, Michael D. Feldman, Michael Yang, Pingfu Fu, Kurt A. Schalper, Haider Mahdi, Cheng Lu, Vamsidhar Velcheti, Anant Madabhushi
Summary: This study utilizes image analysis to capture morphologic attributes and evaluates their association with survival in lung cancer and gynecological cancer patients treated with immune checkpoint inhibitors (ICIs).
Article
Oncology
Amr Mohamed, Namrata Vijayvergia, Matthew Kurian, Lisa Liu, Pingfu Fu, Satya Das
Summary: This study retrospectively analyzed the treatment outcomes of EP-NEC patients and found that dual ICPIs showed better progression-free survival and overall survival in patients with EP-NEC in the second-line setting, compared to single ICPIs or cytotoxic chemotherapy.
Article
Oncology
Sara Arabyarmohammadi, Patrick Leo, Vidya Sankar Viswanathan, Andrew Janowczyk, German Corredor, Pingfu Fu, Howard Meyerson, Leland Metheny, Anant Madabhushi
Summary: Computer-extracted morphology and texture features from chromatin patterns of myeloblasts can predict post-HCT relapse and prognosticate RFS in patients with AML/MDS.
JCO CLINICAL CANCER INFORMATICS
(2022)
Article
Medicine, General & Internal
Gourav Modanwal, Sadeer Al-Kindi, Jonathan Walker, Rohan Dhamdhere, Lei Yuan, Mengyao Ji, Cheng Lu, Pingfu Fu, Sanjay Rajagopalan, Anant Madabhushia
Summary: This study presents a deep-learning-based hepatic fat assessment (DeHFt) pipeline for segmenting and estimating liver attenuation on CT images, and investigates the association between hepatic steatosis and the severity of COVID-19 infections. The results show that DeHFt pipeline accurately assesses hepatic steatosis and reveals its association with the severity of COVID-19 infections.
Article
Multidisciplinary Sciences
Mehdi Alilou, Mohammadhadi Khorrami, Prateek Prasanna, Kaustav Bera, Amit Gupta, Vidya Sankar Viswanathan, Pradnya Patil, Priya Darsini Velu, Pingfu Fu, Vamsidhar Velcheti, Anant Madabhushi
Summary: The study found that the quantitative vessel tortuosity (QVT) imaging biomarker has the potential to predict the response and survival of patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitor (ICI) therapy.
Article
Oncology
Cristian Barrera, German Corredor, Vidya Sankar Viswanathan, Ruiwen Ding, Paula Toro, Pingfu Fu, Christina Buzzy, Cheng Lu, Priya Velu, Philipp Zens, Sabina Berezowska, Merzu Belete, David Balli, Han Chang, Vipul Baxi, Konstantinos Syrigos, David L. Rimm, Vamsidhar Velcheti, Kurt Schalper, Eduardo Romero, Anant Madabhushi
Summary: The tumor immune composition has an impact on prognosis and treatment sensitivity in lung cancer. Effective adaptive immune responses are associated with better clinical outcomes after immune checkpoint blockers, while immunotherapy resistance can occur due to T-cell exhaustion, immunosuppressive signals, and regulatory cells. This study investigates a new computational pathology approach called PhenoTIL, which uses machine learning to analyze the spatial interactions and functional features of immune cell niches associated with tumor rejection and patient outcomes in non-small cell lung cancer (NSCLC). The study demonstrates the potential of PhenoTIL as a valuable biomarker for treatment-specific outcomes in NSCLC.
NPJ PRECISION ONCOLOGY
(2023)
Article
Oncology
Bolin Song, Kailin Yang, Vidya Sankar Viswanathan, Xiangxue Wang, Jonathan Lee, Sarah Stock, Pingfu Fu, Cheng Lu, Shlomo Koyfman, James S. Lewis, Anant Madabhushi
Summary: This study aimed to develop and validate a prognostic and predictive radiomic image signature (pRiS) using CT scans to inform survival and chemotherapy benefit in HPV-associated OPSCC. The results showed that pRiS was able to predict patient survival and determine whether chemotherapy provided additional benefit.
NPJ PRECISION ONCOLOGY
(2023)
Article
Oncology
Afshin Dowlati, Ata Abbas, Timothy Chan, Brian Henick, Xuya Wang, Parul Doshi, Pingfu Fu, Jyoti Patel, Fengshen Kuo, Han Chang, David Balli
Summary: This study found that mutations in the RB1 gene are associated with survival outcomes in small-cell lung cancer (SCLC) patients treated with immune checkpoint blockade (ICB). RB1 mutant tumors showed downregulated expression of immune-related genes and an immune exclusion phenotype. SCLC patients with wild-type RB1 status or lower RB1 gene loss-of-function signature scores have better outcomes with ICB monotherapy.
JCO PRECISION ONCOLOGY
(2022)