Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
Published 2013 View Full Article
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Title
Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
Authors
Keywords
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Journal
Pigment Cell & Melanoma Research
Volume 27, Issue 2, Pages 253-262
Publisher
Wiley
Online
2013-11-28
DOI
10.1111/pcmr.12197
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- (2012) Jeffrey A. Sosman et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2012) Ophélia Maertens et al. Cancer Discovery
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