Near-genomewide RNAi screening for regulators of BRAFV600E-induced senescence identifiesRASEF, a gene epigenetically silenced in melanoma

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Genome-wide promoter methylation analysis identifies epigenetic silencing ofMAPK13in primary cutaneous melanoma

(2013) Linda Gao et al.   Pigment Cell & Melanoma Research

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

(2012) L. C. W. Vredeveld et al.   GENES & DEVELOPMENT

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Small GTPase RAB45-mediated p38 activation in apoptosis of chronic myeloid leukemia progenitor cells

(2011) S. Nakamura et al.   CARCINOGENESIS

Antagonistic TSC22D1 variants control BRAFE600-induced senescence

(2011) Cornelia Hömig-Hölzel et al.   EMBO JOURNAL

A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

(2011) Satoru Yokoyama et al.   NATURE

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma

(2011) Todd D Prickett et al.   NATURE GENETICS

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

(2011) Xiaomu Wei et al.   NATURE GENETICS

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Integrative analysis of the melanoma transcriptome

(2010) M. F. Berger et al.   GENOME RESEARCH

RASandRAFmutations in banal melanocytic aggregates contiguous with primary cutaneous melanoma: clues to melanomagenesis

(2009) O.E. Dadzie et al.   BRITISH JOURNAL OF DERMATOLOGY

Functional identification of LRF as an oncogene that bypasses RAS V12 -induced senescence via upregulation of CYCLIN E

(2009) Liesbeth C.W. Vredeveld et al.   CARCINOGENESIS

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

(2009) Lavanya H Palavalli et al.   NATURE GENETICS

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4

(2009) Todd D Prickett et al.   NATURE GENETICS

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma

(2008) W. M. Lin et al.   CANCER RESEARCH

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

(2008) Narendra Wajapeyee et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY