Journal
PIGMENT CELL & MELANOMA RESEARCH
Volume 26, Issue 5, Pages 723-726Publisher
WILEY-BLACKWELL
DOI: 10.1111/pcmr.12118
Keywords
ruby-eye; Hermansky-Pudlak syndrome; Melanocyte; Eumelanin; Pheomelanin
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Funding
- Japan Society for the Promotion of Science [20591357]
- Grants-in-Aid for Scientific Research [20591357, 24500450] Funding Source: KAKEN
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The novel mutation named ru2(d)/Hps5(ru2-d), characterized by light-colored coats and ruby-eyes, prohibits differentiation of melanocytes by inhibiting tyrosinase (Tyr) activity, expression of Tyr, Tyr-related protein 1 (Tyrp1), Tyrp2, and Kit. However, it is not known whether the ru2(d) allele affects pheomelanin synthesis in recessive yellow (e/Mc1r(e)) or in pheomelanic stage in agouti (A) mice. In this study, effects of the ru2(d) allele on pheomelanin synthesis were investigated by chemical analysis of melanin present in dorsal hairs of 5-week-old mice from F-2 generation between C57BL/10JHir (B10)-co-isogenic ruby-eye 2(d) and B10-congenic recessive yellow or agouti. Eumelanin content was decreased in ruby-eye 2(d) and ruby-eye 2(d) agouti mice, whereas pheomelanin content in ruby-eye 2(d) recessive yellow and ruby-eye 2(d) agouti mice did not differ from the corresponding Ru2(d)/- mice, suggesting that the ru2(d) allele inhibits eumelanin but not pheomelanin synthesis.
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