Review
Integrative & Complementary Medicine
Ga-Young Lee, Jin-Seok Lee, Chang-Gue Son, Nam-Hun Lee
Summary: Colorectal cancer patients often experience treatment failure due to acquired drug resistance, and herbal medicines may serve as promising candidates to reverse this resistance, potentially developing into new adjuvant chemotherapy drugs.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Ying Tan, Heping Wang, Bowen Xu, Xiaoxiao Zhang, Guanghui Zhu, Yuansha Ge, Taicheng Lu, Ruike Gao, Jie Li
Summary: This study systematically evaluated the efficacy of Chinese herbal medicine combined with oxaliplatin-based chemotherapy in AGC, demonstrating that the combination therapy can improve ORR and DCR while reducing toxicities and side effects of chemotherapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Yuanyuan Chen, Chien-shan Cheng, Hor-Yue Tan, Chi Wing Tam, Ning Wang, Yibin Feng
Summary: This review evaluates the efficacy of traditional herbal medicines in alleviating chemotherapy-induced gastrointestinal toxicity and suggests that herbal medicines combined with chemotherapy can significantly reduce symptoms of CIGI toxicity, although no significant effects were seen in studies with a double-blind design. Further research and well-designed trials are needed to evaluate treatment efficacy comprehensively.
FRONTIERS IN ONCOLOGY
(2021)
Review
Immunology
Fan Bu, Yifeng Tu, Ziang Wan, Shiliang Tu
Summary: It is well-established that gut microbiota (GM) and its metabolites can cause cancer by disrupting immune responses. Recent advancements in sequencing technology and germ-free models have allowed significant progress in understanding the role of GM in colorectal cancer (CRC) development. Traditional Chinese medicine (TCM), as a rich source of natural medicines, holds great potential as anti-CRC agents, particularly in targeting gut microbes for treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jee-Hyun Yoon, Eun Hye Kim, Su Bin Park, Jee Young Lee, Seong Woo Yoon
Summary: This study evaluated the efficacy and safety of traditional herbal medicine (THM) for improving sleep quality in cancer patients, showing significant improvement compared to hypnotics and placebos. However, further rigorous randomized controlled trials are needed to confirm these findings due to limitations in methodological quality and inconsistent results from included trials.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Hua-Zhong Ying, Wei Xie, Meng-Chuan Wang, Jia-Qi He, Huan-Huan Zhang, Chen-Huan Yu
Summary: Gut dysbiosis plays a crucial role in the development of colorectal cancer, affecting the absorption and metabolism of drugs and subsequently impacting the clinical outcomes of patients. Natural herbs, as a novel source of anticancer drugs, have shown promising effects in improving gut microbiota composition, repairing intestinal barrier, and reducing inflammation in CRC models.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Nutrition & Dietetics
Ji Hee Jun, Tae Young Choi, Hye Won Lee, Lin Ang, Myeong Soo Lee
Summary: RCT studies on herbal medicine decoctions for treating Behcet's disease showed significant effects on the total response rate and erythrocyte sedimentation rate, but not on C-reactive protein level. Herbal medicine also significantly decreased the recurrence rate after three months of follow-up.
Article
Chemistry, Medicinal
Guoming Chen, Ning Wang, Ruifeng Yang, Yixuan Wu, Jiaming Liu, Zhiqiang Huang, Zhenyu Zhang, Yuxin Huang, Cheng Zhang, Yau-Tuen Chan, Yibin Feng
Summary: Cancer-induced cachexia is a global public health issue, and herbal medicines, especially Traditional Chinese Medicine, have been reported to effectively treat cachexia. This study included 66 studies and found that herbal medicines or combined treatment with conventional therapy have an ameliorating effect on cachexia. However, further high-quality research is needed to confirm the clinical efficacy of herbal medicines, as the quality of included studies is not high.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shing-Yau Tam, Md Zahirul Islam Khan, Ju-Yu Chen, Jerica Hiu-Yui Yip, Hong-Yiu Yan, Tsz-Yan Tam, Helen Ka-Wai Law
Summary: The study aimed to investigate the differences in chemotherapy responses between FOLFOX-resistant and wild-type colorectal cancer cells using proteomic profiling. FOLFOX-resistant cells (DLD1-R and HCT116-R) were developed through chronic exposure to progressive FOLFOX doses. Analysis of the proteomic profiles revealed significantly altered pathways in FOLFOX-resistant cells, with up-regulations in the ribosomal process and actin cytoskeleton. These findings suggest potential novel treatment targets for overcoming chemoresistance in colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Paula I. Escalante, Luis A. Quinones, Hector R. Contreras
Summary: The FOLFOX scheme is commonly used for metastatic colorectal cancer patients, but chemoresistance is a major challenge. EMT and overexpression of multiple genes may contribute to drug resistance.
Review
Chemistry, Medicinal
Chan-Young Kwon, Boram Lee, Moonkyo Kong, Seung Hyeun Lee, Hee-Jae Jung, Kwan-Il Kim, Beom-Joon Lee
Summary: In lung cancer patients, herbal medicines combined with conventional medicine significantly improved fatigue, quality of life, and activities of daily life, while monotherapy with herbal medicines also significantly improved activities of daily life. Limited evidence suggests that herbal medicines could be effective and safe for cancer-related fatigue in lung cancer patients.
PHYTOTHERAPY RESEARCH
(2021)
Review
Plant Sciences
Lin Ang, Eunhye Song, Junhua Zhang, Hye Won Lee, Myeong Soo Lee
Summary: This overview of systematic reviews on herbal medicine interventions for COVID-19 shows that although there is some evidence supporting the advantages of herbal therapy, the quality of the evidence is inadequate to make definitive and accurate judgments.
Review
Oncology
Shao-Hua Yan, Shuo Feng, Yun Xu, Yun-Zi Yan, Bin He, Ling-Yun Sun, Bing Pang, Wen-Jia Liu, Yu-Ying Xu, Na Zhao, Mo Tang, Yue Chen, Ming-Kun Yu, Yu-Fei Yang
Summary: The study demonstrated through meta-analysis that Chinese Herbal Medicine can significantly reduce the incidence of leukopenia and neutropenia in patients with colorectal cancer undergoing chemotherapy, especially decreasing the occurrence of severe neutropenia.
INTEGRATIVE CANCER THERAPIES
(2021)
Review
Oncology
Keyla Vargas-Roman, Maria Isabel Tovar-Galvez, Antonio Linan-Gonzalez, Guillermo Arturo Canadas de la Fuente, Emilia Inmaculada de la Fuente-Solana, Lourdes Diaz-Rodriguez
Summary: This article summarizes the impact of coping strategies on the quality of life of colorectal cancer patients. The results suggest that coping strategies can help patients adapt and overcome the stress caused by the disease. For elderly patients, learning coping strategies may improve their quality of life after cancer diagnosis. However, more research is needed to validate this hypothesis, as there is limited randomized evidence available.
Review
Oncology
Youjin Jung, Joohyun Chung, Heesook Son
Summary: Physical activity interventions have been shown to effectively improve disease-specific quality of life and PA level, but not fatigue and body mass index among colorectal cancer survivors. Further randomized controlled trials are needed to determine the optimal mode of PA intervention delivery for this group.
Article
Health Care Sciences & Services
Yiyi Cai, Claire Shuiqing Zhang, Anthony Lin Zhang, Cliff Da Costa, Charlie Changli Xue, Zehuai Wen
Summary: This preliminary study on electroacupuncture for poststroke spasticity found no significant difference in outcomes between the intervention group and control group in terms of MAS, Fugl-Meyer Assessment, or Barthel Index. Longer treatment and follow-up periods are recommended for future full-scale trials to evaluate the effectiveness and safety of EA more accurately.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2021)
Letter
Obstetrics & Gynecology
Xindong Qin, Meaghan E. Coyle, Anthony L. Zhang, Lihong Yang, Charlie C. L. Xue, Xusheng Liu
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Integrative & Complementary Medicine
Yihan He, Haibo Zhang, Yifang Li, Shunqin Long, Shujing Xiao, Brian H. May, Anthony Lin Zhang, Xinfeng Guo, Charlie Changli Xue, Chuanjian Lu
Summary: The study found that acupuncture as an adjunctive therapy for cancer pain was effective in reducing pain intensity and daily opioid consumption. Patients in the acupuncture group had a higher proportion of experiencing pain relief compared to the control group. No serious adverse events were reported during the treatment. Further evaluation of the clinical effects of acupuncture as an adjunctive therapy is needed.
ACUPUNCTURE IN MEDICINE
(2022)
Review
Integrative & Complementary Medicine
Long Ge, Qi Wang, Yihan He, Darong Wu, Qi Zhou, Nenggui Xu, Kehu Yang, Yaolong Chen, Anthony Lin Zhang, Haiqing Hua, Jinchang Huang, Ka-Kit Hui, Fanrong Liang, Linpeng Wang, Bin Xu, Yufei Yang, Weimin Zhang, Baixiao Zhao, Bing Zhu, Xinfeng Guo, Charlie Changli Xue, Haibo Zhang, Charlie Changli Xue, Charlie Changli Xue, Haibo Zhang, Xinfeng Guo, Darong Wu, Kehu Yang, Yaolong Chen, Long Ge, Runsen He, Haiqing Hua, Jinchang Huang, Ka-Kit Hui, Fanrong Liang, Zuodi Pan, Linpeng Wang, Bin Xu, Nenggui Xu, Yufei Yang, Anthony Lin Zhang, Weimin Zhang, Baixiao Zhao, Bing Zhu, Qi Wang, Yihan He, Qi Zhou, Lihong Yang, Shaonan Liu, Jieyun Li, Liangying Hou, Qian Zhang, Honghao Lai, Xueling Chen, Xueyi Deng, Fuqin Kang
Summary: This study aims to develop an evidence-based clinical practice guideline for acupuncture in the treatment of patients with moderate and severe cancer pain. The guideline proposed three recommendations, providing guidance for the management of cancer pain patients.
Article
Multidisciplinary Sciences
Shaohua Lyu, Claire Shuiqing Zhang, Anthony Lin Zhang, Jingbo Sun, Charlie Changli Xue, Xinfeng Guo
Summary: This real-world observational study aims to gather practice-based evidence of effects and safety of Chinese herbal medicine (CHM) for migraine, exploring factors related to clinical outcomes. The study will provide comprehensive evidence of CHM for migraine in the context of evidence-based practice and integrate Chinese medicine diagnostic procedures, patients' preferences, and matters relevant to clinical decision making.
Article
Integrative & Complementary Medicine
Zhen Zheng, Wanda S. Stelmach, Jason Ma, Juris Briedis, Raphael Hau, Mark Tacey, Jeannette Atme, Debra Bourne, Julie Crabbe, Catherine Fletcher, Paul Howat, Jenny Layton, Charlie C. Xue
Summary: This study surveyed healthcare professionals' attitudes towards acupuncture/acupressure and barriers to implementation. The results showed that despite considering it non-mainstream, hospital-based healthcare professionals strongly supported the evidence-based use of acupuncture/acupressure and expressed a desire to learn more.
ACUPUNCTURE IN MEDICINE
(2023)
Review
Endocrinology & Metabolism
Jiaxin Chen, Johannah L. Shergis, Xinfeng Guo, Anthony Lin Zhang, Hanlin Wang, Chuanjian Lu, Charlie C. Xue, Changcai Xie
Summary: This research updates and synthesizes evidence from systematic reviews on acupuncture therapies for treating overweight and obesity. It found that acupuncture therapies and auricular acupoint stimulation have benefits in reducing body weight and body mass index. However, there is insufficient evidence for the use of catgut embedding therapy and abdominal acupuncture. Larger and more methodologically sound randomized controlled trials are needed to evaluate the effectiveness of acupuncture therapies.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Review
Clinical Neurology
Shaohua Lyu, Claire Shuiqing Zhang, Xinfeng Guo, Anthony Lin Zhang, Jingbo Sun, Genghang Chen, Charlie Changli Xue, Xiaodong Luo
Summary: Oral Chinese herbal medicine appears to be more effective than placebo in reducing migraine frequency and pain severity. Greater treatment effects were associated with longer treatment duration, and it was well tolerated.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Qianqian Guo, Meaghan E. Coyle, Anthony Lin Zhang, Xiaohong Xue, Weihe Bian, Aili Song, Xiaohong Xie, Ri Hong, Gang Lyu, Lifang Liu, Qianjun Chen, Charlie Changli Xue
Summary: This multicenter clinical study aimed to identify the Chinese medicine (CM) syndromes and clinical signs and symptoms in women with early breast cancer. The study found consistency between cluster analysis results and the most common syndromes recorded in medical records, and identified the unique syndromes for different treatment stages.
FRONTIERS IN ONCOLOGY
(2022)
Article
Area Studies
Caragh Brosnan, Fran M. Collyer, Karen Willis, Anthony L. Zhang
Summary: Despite being seen as alternative medicine, Traditional Chinese Medicine (TCM) has been assimilated into mainstream scientific knowledge production and legitimation, even being included in the International Classification of Diseases. In Australia, TCM is a designated area of cooperation with China and is researched by mainstream scientists in universities. This study examines the reasons why TCM has transcended scientific skepticism and identifies aspects of TCM that serve as boundary objects, facilitating its acceptance in bioscientific disciplines.
EAST ASIAN SCIENCE TECHNOLOGY AND SOCIETY-AN INTERNATIONAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Claire Shuiqing Zhang, Shaohua Lyu, Anthony Lin Zhang, Xinfeng Guo, Jingbo Sun, Chuanjian Lu, Xiaodong Luo, Charlie Changli Xue
Summary: This study searches and analyzes traditional Chinese medicine literature to discover clinical management approaches and herbal medicines for migraine treatment. The anti-migraine effects and mechanisms of action of these herbs and formulas are summarized.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Multidisciplinary Sciences
Yuan Ming Di, Lu Sun, Chuanjian Lu, Xin Feng Guo, Xianyu Tang, Anthony Lin Zhang, Guanjie Fan, Charlie Changli Xue
Summary: Evidence from this study supports the use of Fuling formulae combined with hypoglycaemic agents for the treatment of type 2 diabetes mellitus. The combined therapies appear to be well tolerated.
Article
Medicine, General & Internal
Shaohua Lyu, Claire Shuiqing Zhang, Jingbo Sun, Heng Weng, Charlie Changli Xue, Xinfeng Guo, Anthony Lin Zhang
Summary: This retrospective study analyzed electronic medical records of 2023 migraine patients at the Guangdong Provincial Hospital of Chinese Medicine. Chinese herbal medicine was found to be the predominant treatment for migraines at the hospital, and stress was the most common trigger for migraines.
FRONTIERS IN MEDICINE
(2022)
Review
Multidisciplinary Sciences
Yi Cheng, Yuan Ming Di, Anthony Lin Zhang, Beiping Zhang, Charlie Changli Xue
Summary: This review aims to evaluate the effectiveness and safety of oral Chinese herbal medicine in reducing colorectal adenoma recurrence compared to other treatments. It will provide critical information for clinicians and countries to develop clinical guidelines on colorectal adenoma management.
