Article
Chemistry, Medicinal
Saeid Hadi, Reza Daryabeygi-Khotbehsara, Parvin Mirmiran, Jenna McVicar, Vahid Hadi, Davood Soleimani, Gholamreza Askari
Summary: The study demonstrated that Nigella sativa oil extract had beneficial effects on glycemic control, serum lipid profile, blood pressure, and body weight among people with type 2 diabetes. Further long-term trials are needed to confirm the therapeutic benefits of Nigella sativa in T2D.
PHYTOTHERAPY RESEARCH
(2021)
Article
Food Science & Technology
K. V. Harivaindaran, Nguyen Huu Tien, Toan Nguyen Song Dinh, Hayati Samsudin, Fazilah Ariffin, Abdorreza Mohammadi Nafchi
Summary: The study found that superheated steam (SHS) roasting can better preserve the quality of black seeds, with improved antioxidant activity and oil quality.
FOOD SCIENCE & NUTRITION
(2023)
Review
Immunology
Opeyemi Oluwafemi Ojueromi, Ganiyu Oboh, Ayokunle Olubode Ademosun
Summary: This article reviews the anti-inflammatory and immunomodulatory properties of Nigella sativa and its bioactive compounds, as well as their potential in treating disorders linked to inflammation and immune dysregulation.
INFLAMMOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Safialdin Alsanosi, Ryan A. Sheikh, Sultan Sonbul, Hisham N. Altayb, Afnan S. Batubara, Salman Hosawi, Kaltoom Al-Sakkaf, Omeima Abdullah, Ziad Omran, Mahmoud Alhosin
Summary: Nigella sativa oil, commonly known as black seed oil (BSO), contains the active compound thymoquinone (TQ) which inhibits cell proliferation and induces apoptosis by targeting epigenetic factors and proteins. This study compared the effects of BSO and pure TQ on cancer cells and found that both had similar inhibitory and apoptotic effects. Molecular docking and simulation showed that TQ had good binding affinity to UHRF1 and HDAC1, suggesting it as a promising strategy for epigenetic therapy.
Article
Chemistry, Medicinal
Omid Mohammad Tavakoli-Rouzbehani, Mohsen Abbasnezhad, Sorayya Kheirouri, Mohammad Alizadeh
Summary: The study shows that Nigella sativa has potential beneficial effects on metabolic parameters in coronary artery disease patients, including improvements in anthropometric indices, blood pressure, and fasting blood glucose levels.
PHYTOTHERAPY RESEARCH
(2021)
Article
Food Science & Technology
Sidika Ekren, Ismail Can Paylan, Adem Gokcol
Summary: This study aimed to improve the germination rate and emergence rate of black cumin seeds by enhancing seed quality. The researchers found that seed priming and coating techniques were effective in increasing the germination rate. Additionally, hot water and ozone treatments were successful in eliminating cucumber mosaic virus from black cumin seeds.
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2023)
Review
Food Science & Technology
Muhammad Abdul Rahim, Aurbab Shoukat, Waseem Khalid, Afaf Ejaz, Nizwa Itrat, Iqra Majeed, Hyrije Koraqi, Muhammad Imran, Mahr Un Nisa, Anum Nazir, Wafa S. Alansari, Areej A. Eskandrani, Ghalia Shamlan, Ammar AL-Farga
Summary: This review examines the effects of black seed on human health and its applications in food products. Black seed oil contains essential fatty acids, but has low oxidative stability. Different encapsulation methods can be used to improve the stability of black seed oil. Thymoquinone in black seed and oil has various biological activities and can be used to reduce the risk of cardiovascular diseases, cancer, and diabetes.
Article
Horticulture
Zainab Albakry, Emad Karrar, Isam A. Mohamed Ahmed, Emel Oz, Charalampos Proestos, Aly Farag El Sheikha, Fatih Oz, Gangcheng Wu, Xingguo Wang
Summary: This study assessed the nutritional quality and bioactive properties of black cumin seeds and oil commonly found in the Chinese market. The results showed that black cumin seeds are nutritionally rich and have high potential applications in the food, pharmaceutical, and cosmetic industries.
Review
Chemistry, Medicinal
Zeynab Kavyani, Vali Musazadeh, Ehsan Safaei, Mina Mohammadi Asmaroud, Fatemeh Khashakichafi, Sana Sedgh Ahrabi, Parvin Dehghan
Summary: This study aims to examine the effects of N. sativa on blood pressure in adults. The meta-analysis suggests that N. sativa supplementation can effectively reduce both systolic and diastolic blood pressure, indicating that it could be used as an effective approach to blood pressure management.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Medicinal
Afsaneh Alizadeh, Sakineh Mohammah-Alizadeh-Charandabi, Laleh Khodaie, Mojgan Mirghafourvand
Summary: This study investigated the effects of Nigella sativa L. seed oil on urinary incontinence, quality of life, and sexual function in menopausal women. The results showed a positive effect on mixed urinary incontinence and incontinence-QoL, but no significant impact on stress incontinence, urge incontinence, sexual function, and menopause-specific QoL.
PHYTOTHERAPY RESEARCH
(2023)
Article
Food Science & Technology
Najwa Yanya Santiworakun, Acharee Suksuwan, Sukrit Sirikwanpong, Winai Dahlan, Tipayanate Ariyapitipun
Summary: Black cumin seed oil was successfully microencapsulated using spray drying with high encapsulation efficiency. The combination of inulin and whey protein showed promising results with a microencapsulation efficiency of 86.12% and excellent spherical shape of the microcapsules. The microencapsulated powders exhibited improved wettability, solubility, and thymoquinone content compared to those prepared with gum arabic alone.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuri Yoshioka, Shinichi Matsumura, Masanori Morimoto
Summary: The study evaluated the deodorant activity of black cumin seed against organosulfur compounds related to garlic odor, finding that black cumin seed essential oil showed remarkable deodorant activity against garlic essential oil, presumably by covalently reacting with the sulfur compounds. This reaction, particularly with thymoquinone and allyl mercaptan, was identified as a key factor in the deodorizing effect.
Article
Chemistry, Medicinal
Parisa Shoaei-Hagh, Farzaneh Kamelan Kafi, Sara Najafi, Mansoureh Zamanzadeh, Alireza Heidari Bakavoli, Javad Ramezani, Samira Soltanian, Javad Asili, Hossein Hosseinzadeh, Saeid Eslami, Zhila Taherzadeh
Summary: The study evaluated the efficacy, safety, and utility of Nigella sativa seeds oil as a complementary treatment for hypertension, glucose control, and lipid metabolism. Results showed that the use of N. sativa seeds oil as an adjunct to common medications exhibited significant antihypertensive effects and beneficial effects on glucose control and lipid metabolism in hypertensive patients.
PHYTOTHERAPY RESEARCH
(2021)
Article
Plant Sciences
B. Gopane, C. D. Kaptchouang Tchatchouang, T. Regnier, C. N. Ateba, M. C. Manganyi
Summary: Endophytic fungi isolated from black seeds were characterized by their biodiversity, stress tolerance, and classification into the Ascomycota phylum. The study revealed that medicinal plants, such as Nigella sativa, are a rich source of novel endophytic fungi with potential therapeutic and agricultural applications.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Food Science & Technology
Mehmet Kemal, Ulku Zeynep Ureyen Esertas, Esra Demir Kanbur, Yakup Kara, Ali Erdem Ozcelik, Zehra Can, Sevgi Kolayli
Summary: This study investigated the compositions, antioxidant and antimicrobial properties of black cumin honey from the Burdur region of Turkiye. The honey samples had various physicochemical properties, phenolic contents, and exhibited high antimicrobial activities against several bacteria. They also showed significant antioxidant capacities. The phenolic composition of the samples was analyzed using HPLC-PDA method and several common components were identified.
Article
Plant Sciences
Yunes Panahi, Parisa Kianpour, Reza Mohtashami, Sara Saffar Soflaei, Amirhossein Sahebkar
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2019)
Article
Plant Sciences
Ahmad Khonche, Hasan Fallah Huseini, Mandi Gholamian, Reza Mohtashami, Farzaneh Nabati, Saeed Kianbakht
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Chemistry, Medicinal
Akbar Asadi, Farzad Shidfar, Mostafa Safari, Agha Fatemeh Hosseini, Hasan Fallah Huseini, Iraj Heidari, Asadollah Rajab
PHYTOTHERAPY RESEARCH
(2019)
Article
Dermatology
Hasan Fallah Huseini, Amir Hossein Abdolghaffari, Maryam Ahwazi, Eghbal Jasemi, Maryam Yaghoobi, Mojtaba Ziaee
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2020)
Article
Chemistry, Medicinal
Saeed Kianbakht, Reza Hajiaghaee, Shahin Akhondzadeh
PHYTOTHERAPY RESEARCH
(2020)
Article
Dermatology
Hasan Fallah Huseini, Maryam Yaghoobi, Farhad Fallahi, Farzaneh Boroumand, Mohammad Hassan Ezzati, Seyyed Mohammad Tabatabaei, Homa Sotvan, Maryam Ahvazi, Shapour Badiee Aval, Mojtaba Ziaee
Summary: The study confirms that the addition of topical T. polium ointment significantly improves the healing time of diabetic non-infected foot ulcers as a supplementary to standard treatment.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2021)
Article
Integrative & Complementary Medicine
Hasan Fallah Huseini, Reza Mohtashami, Elaheh Sadeghzadeh, Soraya Shadmanfar, Fataneh Hashem-Dabaghian, Saeed Kianbakht
Summary: This study evaluated the efficacy and safety of Nigella sativa oil in the treatment of knee osteoarthritis. The results showed that NS oil can safely reduce symptoms and analgesic dose, and improve patient satisfaction.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2022)
Article
Integrative & Complementary Medicine
Reza Mohtashami, Fataneh Hashem-Dabaghian, Farzaneh Nabati, Ardeshir Qaderi, Saeed Kianbakht
Summary: The topical use of oleoresin of Pistacia atlantica subspecies kurdica (OPAK) was found to be safe and effective in relieving joint pain, stiffness, and dysfunction in patients with knee osteoarthritis. The OPAK group had significantly lower use of acetaminophen tablets, higher SF-12 scores, and lower HAQ-DI scores compared to the placebo group. No significant side effects were observed.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Integrative & Complementary Medicine
Fataneh Hashem-Dabaghian, Saeed Kianbakht
Summary: The efficacy and safety of a standardized extract of Sophora alopecuroides var. alopecuroides for the treatment of acute heroin withdrawal syndrome was evaluated. The experimental group showed a significant decrease in withdrawal syndrome scores after eight days of treatment, with no significant effect on other parameters. The extract appears to safely alleviate acute heroin withdrawal syndrome.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2023)
Article
Materials Science, Biomaterials
Samere Abolghasemzade, Mehrab Pourmadadi, Hamid Rashedi, Fatemeh Yazdian, Saeed Kianbakht, Mona Navaei-Nigjeh
Summary: The novel BC-CQD/Si NP/SF nanocomposite and PVA-CQD/Si NP/SF nanofiber wound dressings exhibit strong antibacterial activity and the ability to promote wound healing.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Nutrition & Dietetics
Saeed Mehrzadi, Reza Mirzaei, Mojtaba Heydari, Maryam Sasani, Bahman Yaqoobvand, Hasan Fallah Huseini
Summary: Traditional herbal combination may effectively improve glycemic control in type II diabetic patients with relatively low risk of adverse effects, as shown in a study conducted in Iran.
JOURNAL OF DIETARY SUPPLEMENTS
(2021)
Article
Endocrinology & Metabolism
Hossein Mirmiranpour, Hasan Fallah Huseini, Hoda Derakhshanian, Zohreh Khodaii, Bahareh Tavakoli-Far
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2020)
Article
Chemistry, Medicinal
Reza Mohtashami, Hasan Fallah Huseini, Farzaneh Nabati, Reza Hajiaghaee, Saeed Kianbakht
AVICENNA JOURNAL OF PHYTOMEDICINE
(2019)
Article
Food Science & Technology
Elaheh Jozve-Zargarabadi, Vajiheh Fadaei-Noghani, Hasan Fallah Huseini
APPLIED FOOD BIOTECHNOLOGY
(2020)