Journal
PHYTOTHERAPY RESEARCH
Volume 27, Issue 2, Pages 166-172Publisher
WILEY
DOI: 10.1002/ptr.4706
Keywords
type 2 diabetes; fermented ginseng extract; mice; anti-hyperglycemia; antiinflammation
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Funding
- Gangwon Regional Innovation agency, Ministry of Knowledge Economy
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Ginseng has shown an efficacy in preventing and managing various health conditions. This study aimed to evaluate the effect of the fermented ginseng extract (FGE) in type 2 diabetes mellitus murine model. FGE was provided to male C57BL/ksJ-db/db mice for 8weeks at 0.1% (w/w) dose in contrast to water for the control group. Potential anti-diabetic mechanisms were investigated with blood glucose, serum insulin, serum adiponectin, hemoglobin A1c (HbA1c), glucose tolerance, insulin secretion assay, quantitative real-time polymerase chain reaction, and hematoxylineosin staining. Compared with the control group, the FGE group had lower levels of blood glucose after 6 and 9h fasting, HbA1c, and the area under the curve in an oral glucose tolerance test and higher levels of adiponectin and serum insulin (p<0.05). The FGE group had higher levels of peroxisome proliferator-activated receptor gamma 2 and glucose transporter protein 2 mRNAs, a lower level of tumor necrosis factor- (TNF-) (p<0.05), and less lymphocytes in pancreas than the control group had. The FGE exerted anti-diabetic effects in type 2 diabetic mice. Copyright (c) 2012 John Wiley & Sons, Ltd.
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