Journal
PHYTOTHERAPY RESEARCH
Volume 26, Issue 12, Pages 1904-1912Publisher
WILEY
DOI: 10.1002/ptr.4666
Keywords
flavonoids; Korea Citrus aurantium L.; L6 skeletal muscle cell; lipopolysaccharide (LPS); nuclear factor-kappa B (NF-kappa B); mitogen-activated protein kinases (MAPKs)
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Funding
- National Research Foundation (NRF) of Korea
- Korean government (MEST) [2009-0084454]
- Ministry for Health, Welfare and Family affairs, Republic of Korea [0820050]
- National Research Foundation of Korea [2009-0084454] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Citrus fruits (Citrus aurantium L.) have long been used as a traditional herbal medicine. The benefits of the flavonoids found in Citrus aurantium L. include anti-inflammation, anti-cancer, anti-viral and anti-bacterial activities, and enhancement of the immune response. The study investigated the effect of the flavonoids isolated from Citrus aurantium L. native to Korea on the production of pro-inflammatory mediators by blocking signal transduction mediated by nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinases (MAPKs) in lipopolysaccharide (LPS)-induced L6 skeletal muscle cells. The flavonoids decreased the production of inducible nitric oxide synthase, cyclooxygenase-2, interleukin-6 and tumor necrosis factor-alpha by suppressing NF-kappa B and MAPKs signal pathways in LPS-induced L6 skeletal muscle cells. These findings suggest that the flavonoids isolated from Korea Citrus aurantium L. might have anti-inflammatory effects that regulate the expression of inflammatory mediators in L6 skeletal muscle cells. Copyright (c) 2012 John Wiley & Sons, Ltd.
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