Journal
PHYTOTHERAPY RESEARCH
Volume 25, Issue 4, Pages 624-628Publisher
WILEY-BLACKWELL
DOI: 10.1002/ptr.3306
Keywords
persimmon; tannin; bile acid-binding ability
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Funding
- Agriculture, Forestry and Fisheries Research Council of Japan
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The bile acid-binding ability of a highly polymerized tannin (kaki-tannin) extracted from dried-young fruits of persimmon (Diospyros kaki) was examined. The kaki-tannin was composed mainly of epicatechin, epigallocatechin, epicatechin-3-O-gallate and epigallocatechin-3-O-gallate. Bile acid-binding ability of kaki-tannin was examined against cholic acid, glycocholic acid, taurocholic acid and deoxycholic acid in vitro, and its effect on fecal bile acid excretion in mice was also examined. Although the bile acid-binding ability of kaki-tannin was weaker than that of cholestyramine, kaki-tannin adsorbed all the bile acids tested and significantly promoted fecal bile acid excretion in mice when supplied at 1% (w/w) in the diet. Copyright (C) 2010 John Wiley & Sons, Ltd.
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