Journal
PHYTOTHERAPY RESEARCH
Volume 23, Issue 7, Pages 1039-1042Publisher
WILEY
DOI: 10.1002/ptr.2654
Keywords
daming capsule; hypercholesterolemia; hyperlipidemia
Categories
Funding
- Natural Science Foundation of Heilongjiang Province [ZJY0703-02]
- Natural Science Foundation of China [30672644, 2007CB512006]
- Heilongjiang Postdoctoral Science Starting Foundation
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To study the efficacy and tolerability of Darning capsule (DMC) in Chinese patients with hyperlipidemia, a randomized, multi-centre, open-label, parallel-group trial was conducted. Sixty enrolled patients with hyperlipidemia allocated to six medical centers were randomly divided into two groups of 30 individuals each. One group received DMC 2 g b.i.d. for 6 weeks, and the other received pravastatin 10 mg o.d. for 6 weeks. For efficacy assessment, serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDLC) and high density lipoprotein cholesterol (HDL-C) were measured before and after drug treatment. Serum TC and LDL-C levels in the DMC-treatment group were significantly decreased compared with those before treatment (p < 0.05), while TG and HDL-C levels did not change much. Tolerability was assessed by heart rate (HR), blood pressure (BP), body mass index (BMI), alanine aminotransferase (ALT) and creatinine (Cr), which were not changed in either the DMC or pravastatin groups at 3 and 6 weeks (p > 0.05). Besides, eight patients experienced diarrhea during DMC treatment and two experienced myalgia and epigastric discomfort during pravastatin treatment. Based on the above results, it was concluded that DMC may be a good candidate for the treatment of hyperlipidemia and further clinical trials are warranted. Copyright (C) 2009 John Wiley & Sons, Ltd.
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