Journal
PHYTOTHERAPY RESEARCH
Volume 23, Issue 12, Pages 1731-1733Publisher
WILEY
DOI: 10.1002/ptr.2821
Keywords
Swietenia macrophylla; Meliaceae; swietenine; glucose utilization
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The present study was undertaken to isolate a novel antidiabetic molecule from Swietenia macrophylla seeds. The hydroalcohol extract of Swietenia macrophylla seeds was subjected for bioassay guided isolation employing glucose utilization assay by the isolated rat hemi-diaphragm method in vitro. One tetranortriterpenoid, swietenine, isolated from the chloroform fraction exhibited significant (p < 0.01) activity and the effect was comparable to that of human insulin (p < 0.01). Copyright (C) 2009 John Wiley R Sons, Ltd.
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