Journal
PHYTOMEDICINE
Volume 21, Issue 5, Pages 670-675Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.phymed.2014.01.001
Keywords
Quorum sensing inhibitors; Cecropia; Cecropia pachystachya Trecul; Flavonoids; Rutin; C-glycosyl flavonoids
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Funding
- CNPq
- CAPES
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The Cecropia genus is widely distributed in Latin America including at least 60 species, and some of them are commonly used in traditional medicine for the treatment of several diseases. We used Cecropia pachystachya Trecul to search for quorum sensing (QS) inhibitors compounds and found that the aqueous extract of C pachystachya leaves is a promising source of substances with this activity. Using as biosensor Chromobacterium violaceum ATCC 31532 and Escherichia coli pSB403, the compounds chlorogenic acid (2), isoorientin (3), orientin (4), isovitexin (6), vitexin (7), and rutin (9) were identified as QS inhibitors. None of these compounds inhibited the growth of neither the used biosensors nor the microorganisms Staphylococcus aureus ATCC 23591, Escherichia coli ATCC 25922 and Saccharomyces cerevisiae, used here as growth inhibition controls. Along with the rutin, here we presented for the first time the QS-inhibition potential of the C-glycosyl flavonoids. The prospective of this evidence lead to the use of these compounds as antipathogenic drugs or antifoulants. (c) 2014 Elsevier GmbH. All rights reserved.
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