Journal
PHYTOMEDICINE
Volume 21, Issue 3, Pages 333-339Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2013.08.023
Keywords
7-O-trans-cinnamoyl 6 beta-hydroxyloganin derivatives; Arbortristoside-A; Anticancer agents; Apoptosis; Nyctanthes arbortristis
Categories
Funding
- DST
- ICMR, New Delhi
- [BSC0104i]
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Nyctanthes arbortristis Linn (Oleaceae) is widely distributed in sub-Himalayan regions and southwards to Godavari, India commonly known as Harsingar and Night Jasmine. In continuation of our drug discovery programme on Indian medicinal plants, we isolated arbortristoside-A (1) and 7-O-trans-cinnamoyl 6 beta-hydroxyloganin (2) from the seeds of N. Arbortristis, which exhibited moderate in vitro anticancer activity. Chemical transformation of 2 led to significant improvement in the activity in derivative 8 and 15 against HepG2 (human hepatocellular carcinoma), MCF-7 (breast adenocarcinoma) cell lines. The compounds 8 and 15 were also capable of cell cycle arrest and caspase dependent apoptosis in HepG2 cell lines. These iridoid derivatives hold promise for developing safer alternatives to the marketed drugs. (C) 2013 Elsevier GmbH. All rights reserved.
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