Journal
PHYTOMEDICINE
Volume 16, Issue 12, Pages 1151-1155Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2009.04.007
Keywords
Alpina zerumbet; 1,8-Cineole; Essential oil; Isolated thoracic aorta; Nitric oxide
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
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Vasorelaxant effects of essential oil of Alpinia zerumbet (EOAZ) and its main constituent, 1,8-cineole (CIN) were Studied In rat isolated aorta preparations with intact endothelium, EOAZ (0.01-3000 mu g/ml.) induced significant but Incomplete relaxation of the phenylephrine-induced contraction. all effect that wits abolished by removal of vascular endothelium. However, at the same concentrations (0.01-3000 mu g/ml corresponding to 0 0000647-19.5 mM), CIN induced a complete vasorelaxant. effects (IC50 = 663.2 +/- 63 8 mu g/ml) that were significantly reduced in endothelium-denuded rings (IC50 = 1620.6 +/- 35.7 mu g/ml). Neither EOAZ nor CIN affected the basal tonus of isolated aorta. Vasorelaxant effects of both EOAZ and CIN remained unaffected by the addition of tetraethylamonium chloride (500 mu M) or indomethacin (10 mu M) into the bath, but were significantly reduced by N-G-nitro-L-arginine methyl ester (100 mu M) It IS Concluded that EOAZ induces a potent vasorelaxant effect that Could not be fully attributed to the actions of the main constituent CIN, and appears totally dependent oil the integrity of a functional vascular endothelium. The data is novel and corroborate the popular use of A. zerumbet for the treatment of hypertension. (C) 2009 Elsevier GmbH. All rights reserved
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