Journal
PHYTOCHEMISTRY LETTERS
Volume 28, Issue -, Pages 42-46Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2018.09.007
Keywords
Torreya fargesii Franch; Cephalotaxus alkaloids; Cytototxicity
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Funding
- National Key Research and Development Program of China [2017YFC1704007]
- National Natural Science Foundation of China [81773590, 81561148013]
- Thailand Research Fund [DBG5980002]
- Key Projects of Technological Innovation of Hubei Province [2016ACA138]
- Fundamental Research Funds for the Central University, SouthCentral University for Nationalities [CZP18005, CZQ17010, CZQ17008, CZT18014, CZT18013]
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Two new cephalotaxus alkaloids, torreyafargesines A (1) and B (2), along with sixteen known ones (3-18), were isolated from the leaves and barks of Torreya fargesii Franch. The structures were established on the basis of spectroscopic methods. All compounds were evaluated for their cytotoxicities against human A549 and Hela cell lines. As a result, compound 5 exhibited weak cytotoxicities against both two cell lines, while compounds 2-4 exhibited cytotoxicities to the Hela cell line referring to that of cisplatin.
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