Journal
PHYTOCHEMISTRY LETTERS
Volume 10, Issue -, Pages 276-280Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2014.10.008
Keywords
Heracleum dissectum; Phenylpropanoid; Neolignan glycosides; Coumarin
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Funding
- Fundamental Research Funds for the Central Universities [z201209082, z201205002]
- start scientific research fund for returned overseas students of Ministry of Education of China [940]
- National Natural Science Foundation of China [81102382]
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A new phenylpropanoid, 3-O-(6-O-beta-D-xylopyranosyloxy-beta-D-glucopyranosyl)-4-hydroxy-1-allylbenzene (1) and a new neolignan glycoside, (7S, 8R)-dehydrodiconiferyl alcohol 4-O-beta-D-glucopyranoside-9'-n-butanol ether (2), together with 2 known neolignans (3-4) and 5 known coumarins (5-9) were isolated from the roots of Heracleum dissectum Ledeb. Their structures were elucidated by means of various spectroscopic analyses. Five of the isolated compounds were tested against Hela, HCT-8, and HepG2 cancer cell lines and showed moderate cytotoxic activities with IC50 values between 5.8 and 18.6 mu M. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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