Article
Plant Sciences
Xiaoxia Li, Ping Wu, Hanxiang Li, Jinghua Xue, Hanhong Xu, Xiaoyi Wei
Summary: Formicapyridine-type racemates, streptovertidines, and fasamycin-type compounds were isolated from Streptomyces morookaense SC1169. Some of these compounds exhibited activity against drug-resistant bacteria and human carcinoma cells, demonstrating higher selectivity for bacteria over mammalian cells. Structure-activity relationship analysis suggested chlorination at C-2 improves activity and selectivity. Theoretical simulations supported nonenzymatic pyridine ring formation via dicarbonyl condensation with ammonia.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Huijuan Li, Xinghui Song, Huiru Li, Lifei Zhu, Shengbo Cao, Jifeng Liu
Summary: Two undescribed ether derivatives of sesquiterpenes and one new monoterpene glycoside were isolated from the stems and leaves of I. simonsii. They exhibited antibacterial activity, with compounds 6 and 7 showing good activity against S. aureus and MRSA, and resistance development was not observed.
Article
Chemistry, Medicinal
Jing Xia, Yun Li, Cailu He, Can Yong, Li Wang, Huan Fu, Xiao-Long He, Zhou-Yu Wang, Dong-Fang Liu, Yuan-Yuan Zhang
Summary: A series of pleuromutilin derivatives containing an oxazolidinone skeleton showed potent antibacterial activities against Staphylococcus aureus and Staphylococcus epidermidis. Compound 28 exhibited the most active antibacterial activity in vitro.
ACS INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Ganesan Govindarajan, Priya Mullick, Babu Arulmani Samuel Raj, Pachaiyappan Saravana Kumar, Mysoon M. Al-Ansari, Soundharrajan Ilavenil, Robinson David Jebakumar Solomon
Summary: This study isolated a diverse group of actinomycetes strains from unexplored regions of mangrove sediments, some of which exhibited strong antibacterial activity, particularly against MRSA and Gram-negative bacteria. Through 16S rRNA gene sequence analysis, it was confirmed that these strains shared high similarity with Streptomyces species.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Chemistry, Medicinal
Raj K. C. Hansa, M. M. K. Khan, M. M. Frangie, D. F. Gilmore, R. S. Shelton, A. Savenka, A. G. Basnakian, S. L. Shuttleworth, M. S. Smeltzer, M. A. Alam
Summary: A collection of potent antimicrobials has been synthesized and tested for antibacterial activity, showing low toxicity to human cells. Two compounds were highly effective against Staphylococcus aureus, with a low tendency for resistance development. In vivo mouse studies showed no harmful effects at doses up to 50 mg/kg.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Si-Yu Huang, Xiao Wang, Ding-Yi Shen, Fang Chen, Guang-Yu Zhang, Zhe Zhang, Kang Li, Zhen Jin, Dan Du, You-Zhi Tang
Summary: Novel pleuromutilin derivatives designed and synthesized with 1,2,4-triazole as the linker showed potent antibacterial activities against Staphylococcus aureus, with compound 12 being the most active against MRSA. Compound 12 demonstrated superior antibacterial efficacy in vivo and in vitro, with moderate inhibition on CYP3A4. Molecular modeling revealed strong hydrogen bonds formed by compound 12 with the 50S ribosome, indicating a potential mechanism of action for its antibacterial activity.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Li-Mei Dong, Qiao-Lin Xu, Shao-Bo Liu, Shan-Xuan Zhang, Meng-Fei Liu, Jin-Long Duan, Jin-Kui Ouyang, Jia-Tao Hu, Fen-Yu Fu, Jian-Wen Tan
Summary: Four new germacrane sesquiterpene dilactones, together with five known ones, were isolated from Mikania micrantha. Compound 4 is the first nitrogen-containing sesquiterpenoid isolated from this plant. These compounds showed strong antibacterial activity against various bacteria and cytotoxic activity against tumor cell lines.
Article
Chemistry, Multidisciplinary
Govindan Rajivgandhi, Govindan Ramachandran, Ramachandran Vijayan, Franck Quero, Muthuchamy Maruthupandy, Naiyf S. Alharbi, Shine Kadaikunnan, Manoharan Natesan, Wen-Jun Li
Summary: The emerging threat of extended spectrum beta lactamase (ESBL) producing Gram negative bacteria is a major global concern. Marine Streptomyces xiamenensis GRG 5 has been found to possess excellent antibacterial activity against Pseudomonas aeruginosa and Klebsiella pneumoniae. Compound DTBHAI extracted from this strain can damage the intracellular membrane and outer membrane morphology of ESBL producing bacteria, making it a potential treatment option for related infections.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Katarina Cankar, Johanna Christina Hakkert, Robert Sevenier, Christina Papastolopoulou, Bert Schipper, Joao P. . Baixinho, Naiara Fernandez, Melanie S. Matos, Ana Teresa Serra, Claudia Nunes Santos, Khabat Vahabi, Alain Tissier, Paul Bundock, Dirk Bosch
Summary: This study identifies an enzyme in chicory roots that can synthesize a compound with anti-inflammatory activity, and demonstrates that the accumulation of this compound can be increased through gene editing techniques. This contributes to a better understanding of the synthesis pathway of this compound in chicory and highlights the potential for extracting different health products from chicory.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Applied
Lin Jiang, Hong Pu, Xiangjing Qin, Jianxin Liu, Zhongqing Wen, Yimin Huang, Jingxi Xiang, Yunxi Xiang, Jianhua Ju, Yanwen Duan, Yong Huang
Summary: Two new natural diols and five known compounds were isolated from Streptomyces sp. CB09001, with their absolute configurations established by crystallographic structure analysis. One of the compounds showed significant inhibition of inducible nitric oxide synthase expression in macrophage cells and could be a potential lead for anti-inflammatory drug development.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Ning Wang, Kaihui Zhu, Yuhui Bi, Fei Liu, Zhiguo Yu
Summary: Myzus persicae (Sulzer) is a crop pest causing economic losses globally. Chemical pesticides have been heavily relied upon to manage this pest, resulting in resistance. New compounds effective against M. persicae are needed. Five novel polyketides, strekingmycins A-E (1-5), were isolated from Streptomyces sp. SA61. Their structures were determined using MS, NMR, and X-ray diffraction. Strekingmycins showed activity against M. persicae at concentrations between 4.4 and 9.4 μg/mL.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Medicinal
Qi-Wen Zhang, Jie Ren, Jia-Xun Lu, Xiao-Ying Chen, Xian-Jin He, Qi Wang, Zi-Dan Zhou, Zhen Jin, Zhen-Ling Zeng, You-Zhi Tang
Summary: In this study, a series of pleuromutilin derivatives containing benzimidazole were synthesized and evaluated for their antibacterial activities against Methicillin-resistant Staphylococcus aureus (MRSA). Among these derivatives, compound 58 exhibited superior in vitro antibacterial effect against MRSA with a lower minimal inhibitory concentration than tiamulin. Compound 58 also demonstrated faster bactericidal kinetics, longer post-antibiotic effect, and reduced cytotoxicity compared to tiamulin, making it a potential candidate for combating MRSA infections.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Infectious Diseases
Dina H. Amin, Hayam A. E. Sayed, Ahmed M. Elissawy, Dina E. EL-Ghwas, Abdel Nasser B. Singab
Summary: The research explored desert Actinobacteria from the Sinai Peninsula, showing high inhibitory effects against multidrug-resistant Staphylococcus aureus strains. Compounds with potential antibacterial activities were isolated and purified, including actinomycin D analogues previously not reported from natural sources. This study highlights the potential of Sinai desert ecosystems as rich sources of antibiotic-producing Actinobacteria.
Article
Chemistry, Organic
Wei-Hua Jiao, Jia-Xin Li, Hong-Yan Liu, Xiang-Chao Luo, Tian-Yong Hu, Guo-Hua Shi, Dong-Dong Xie, Hai-Feng Chen, Bao-Hui Cheng, Hou-Wen Lin
Summary: An unusual secomeroterpenoid, dysambiol (1), was isolated from a Dysidea sp. marine sponge collected from the South China Sea. Dysambiol features an unprecedented secomeroterpene scaffold with a rare lactone bridge. Dysambiol displayed potent anti-inflammatory activity in LPS-induced Raw 264.7 macrophages by regulating the NF-κB/MPAK signaling pathway.
Article
Biotechnology & Applied Microbiology
Jun-Pil Jang, Mina Jang, Toshihiko Nogawa, Shunji Takahashi, Hiroyuki Osada, Jong Seog Ahn, Sung-Kyun Ko, Jae-Hyuk Jang
Summary: This study isolated and characterized two new compounds from the culture extract of Streptomyces sp. RK85-270. The structures of these compounds were determined through spectroscopic and spectrometric analysis. One of the compounds exhibited anti-angiogenic activities against human cells. Further experiments revealed that it inhibits angiogenesis through a specific signaling pathway.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Plant Sciences
Yi Zhu, Junlin Wang, Lu Tang, Yuxin Shang, Weiyi Zhao, Wei Zhang, Ping Hai, Yongbiao Zheng, Wenbo Li, Yanfang Su
Summary: One new iridoid glucoside and two new lignan glycosides, along with three known compounds, were isolated from the whole plants of Lancea tibetica. The structures were determined by spectroscopic methods and X-ray crystallographic analysis. One of the new iridoid glucosides and the known compounds exhibited moderate antioxidant activity.
PHYTOCHEMISTRY LETTERS
(2024)
Article
Plant Sciences
Yi Deng, Minghua Chen, Junming Yi, Yuguo Zheng
Summary: This study successfully designed and synthesized a series of quinazolinone derivatives containing purine molecules, and found that some compounds exhibited strong antiviral activity against tobacco mosaic virus. The findings have important implications for further development of antiviral drugs.
PHYTOCHEMISTRY LETTERS
(2024)
