Journal
PHYTOCHEMISTRY LETTERS
Volume 6, Issue 2, Pages 189-192Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2013.01.001
Keywords
Fusarin C; Metarhizium robertsii; Mycotoxin; NG-391; Transcription
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Funding
- Jena School for Microbial Communication (JSMC)
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The clavicipitaceous fungus Metarhizium robertsii produces the fusarin-like mycotoxin NG-391. We report on the biological effects of NG-391 on K-562 human cancer cells, obtained with radionuclide incorporation assays, along with nucleosome release and caspase assays, respectively. Our data suggests that NG-391 does not induce caspase-dependent apoptosis, but interferes with nucleic acid biosynthesis in K-562 human cancer cells, while translation remains unaffected. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
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