Journal
PHYTOCHEMISTRY LETTERS
Volume 5, Issue 4, Pages 752-755Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2012.08.006
Keywords
Gypsophila trichotoma; Triterpenoid saponins; Triterpenes; Cytotoxic activity
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Funding
- DAAD Research Grant for Doctoral Candidates and Young Academics and Scientists
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A new triterpeniod saponin 3-O-beta-arabinopyranosyl-(1 -> 3)-[beta-galactopyranosyl-(1 -> 2)]-beta-glucuronopyranosyl gypsogenin (1), together with the known saponin 3-O-beta-xylopyranosyl-(1 -> 3)-[beta-galactopyranosyl-(1 -> 2)]-beta-glucuronopyranosyl gypsogenin (2), and three known triterpenes gypsogenic acid (3), quillaic acid (4) and gypsogenin (5) were isolated from the roots of Gypsophila trichotoma Wend. (Caryophyllaceae). Their structures were elucidated by chemical and spectral methods. Cytotoxic activity of compounds 1 and 2 were tested against seven human cancer cell lines. Compound 1 showed cytotoxic activity against all of them, while compound 2 only against two cell lines. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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