Antimicrobial metabolites from the aquatic fungus Delitschia corticola

Two new metabolites, (3S*, 4S*, 5S*, 6R*)-4,5,6-trihydroxy-3-methyl-3,4,6,7-tetrahydro-1H-isochromen-8 (5H)-one (1) and (3R*, 4S*)-7-ethyl-3,4,6,8-tetrahydroxy-3,4-dihydronaphthalen-1 (2H)-one (2), were isolated from the culture broth of the aquatic fungus Delitschia corticola YMF 1.01111, together with four known ones, 6-ethyl-7-hydroxyl-2-methoxyjuglone (3), 6-ethyl-2,7-dimethoxyjuglone (4), 6-(1-hydroxyethyl)-2,7-dimethoxyjuglone (5) and sporidesmin A (6). Structures of these compounds were elucidated mainly by NMR spectroscopic and mass spectroscopic methods. Furthermore, the antimicrobial activities of compounds 1-6 were evaluated against a panel of bacteria and fungi. Crown Copyright (C) 2010 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.