Journal
PHYTOCHEMISTRY LETTERS
Volume 1, Issue 1, Pages 49-53Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2007.12.006
Keywords
Prumnopitys andina; Diterpene; Antibacterial; Staphylococcus aureus; Propionibacterium acnes
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Funding
- Stiefel International RD Ltd
- Engineering and Physical Sciences Research Council [GR/R47646/01]
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As part of all on-going project to isolate antibacterial compounds from rare conifer species, a new abietane diterpene, 2 beta-acetoxyferruginol was isolated from the stem bark of Prumnopitys andina. Molecular modelling Studies were conducted to explain some of the NOEs observed in the A-ring of this compound and to support assignment of relative stereochemistry. This new compound had antibacterial activity at 8 mu g/ml against two effluxing strains of Staphylococcus aureus, but interestingly was inactive at 128 mu g/ml against a wild-type strain and against a methicillin-resistant (MRSA) clinical isolate. We have previously demonstrated that ferruginol is active against these four S. aureus stains and therefore the results indicate that the presence of the acetoxy group has a detrimental effect on antibacterial activity against certain strains. 2 beta-Acetoxyferruginol was also assayed against Propionibacterium acnes and was active at 4 mu g/ml. (C) 2008 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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