Article
Biochemistry & Molecular Biology
Heung Joo Yuk, Ji-Yul Kim, Yoon-Young Sung, Dong-Seon Kim
Summary: The rhizomes of Dryopteris crassirhizoma contain potent xanthine oxidase inhibitory compounds, with flavaspidic acid AP showing the strongest inhibitory activity. These inhibitors exhibit reversible and noncompetitive inhibition towards xanthine oxidase.
Article
Pharmacology & Pharmacy
Sumana Bhowmick, Manfred Beckmann, Jianying Shen, Luis A. J. Mur
Summary: This study confirms the authenticity of Dryopteris crassirhizoma and evaluates its antimicrobial activities. The results show that the extracts of Dryopteris crassirhizoma exhibit significant antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA). Further fractionation and characterization identify a fraction enriched with two anti-MRSA compounds, with norflavaspidic acid AB showing unique effects on MRSA cells' bioenergetic transformation and metabolism. This study may have discovered a naturally available compound that could help counter clinically relevant strains with antibiotic resistance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Yue-Yue Song, Xu-Sheng Cui, Liang Xu, Yan-Ping Xing, Che Bian, Yang Qiao, Yan-Yun Yang, Ting-Guo Kang
Summary: The complete mitochondrial genome of Dryopteris crassirhizoma was sequenced for the first time, revealing its genetic relationship and providing a theoretical basis for the establishment of a classification system. Phylogenetic analysis showed that D. crassirhizoma was closely related to Ophioglossum californicum.
MITOCHONDRIAL DNA PART B-RESOURCES
(2021)
Article
Biochemistry & Molecular Biology
Nguyen Viet Phong, Vu Thi Oanh, Seo Young Yang, Jae Sue Choi, Byung Sun Min, Jeong Ah Kim
Summary: This study isolated 30 phloroglucinols from Dryopteris crassirhizoma and identified trimeric phloroglucinols 26-28 as potent inhibitors of PTP1B, suggesting their potential for treating type 2 diabetes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Nguyen Viet Phong, Yan Zhao, Byung Sun Min, Seo Young Yang, Jeong Ah Kim
Summary: This study evaluated the inhibitory activity of phloroglucinols isolated from Dryopteris crassirhizoma on beta-glucuronidase and revealed the competitive mode of inhibition. The results suggest that trimeric phloroglucinols may serve as potential candidates for developing new beta-glucuronidase inhibitors.
Article
Plant Sciences
Ping Hai, Yunqing He, Ruirui Wang, Jian Yang, Yuan Gao, Xudong Wu, Nie Chen, Li Ye, Rongtao Li
Summary: Novel meroterpenoids with unique structures were isolated from D. crassirhizoma, showing promising antifungal and antibacterial activities, indicating their potential as drug candidates.
Article
Agricultural Engineering
Nenghua Chen, Wen Li, Jihui Zhang, Weibin Xu, Zhongnan Wu, Yaolan Li, Yubo Zhang, Qingwen Zhang, Guocai Wang
Summary: Five beta-tocopherol derivatives were isolated from the rhizomes of Dryopteris crassirhizoma, with compound 1 showing comparable anti-respiratory syncytial virus activity to the positive control ribavirin. This suggests potential new applications for the rhizomes of D. crassirhizoma and its derivatives in the pharmaceutical industry.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Ping Hai, Kairui Rao, Na Jiang, Dan Liu, Ruirui Wang, Yuan Gao, Xiaocong Liu, Sihao Deng, Yu Zhou, Xuanqin Chen, Xiaonian Li, Rongtao Li
Summary: Twenty-four racemic acylphloroglucinol meroterpenoids were isolated from Dryopteris crassirhizoma, including eighteen unusual structures and a major component filixic acid ABA. The dimeric acylphloroglucinol derivatives possess unprecedented skeletons of mixed acylphloroglucinol and sesquiterpene biosynthetic origin. The stereochemistries of six reported meroterpenoids were reassigned using two intriguing methods. Two of the isolated compounds (13 and 14) showed obvious inhibitory effects on inflammatory response, while another compound (25) exhibited antiviral efficacy against the influenza virus.
BIOORGANIC CHEMISTRY
(2022)
Article
Genetics & Heredity
Qi Wang, Wenting Xu, Lirong Zhou, Biwei Mai, Naiyun Zhu, Xiaoli Zhao, Zhixian Lei
Summary: The complete chloroplast genome of Dryopteris crassirhizoma Nakai was assembled and analyzed, revealing its genetic composition and evolutionary relationships, particularly its close relation to Lepisorus clathratus from the Polypodiaceae family.
MITOCHONDRIAL DNA PART B-RESOURCES
(2021)
Article
Chemistry, Applied
Xiao-Jun Li, Xiong-Hui Song, Si-Qi Tang, Kai-Xin Wei, Zong-Wu Suo, Yi Xu, Jiao Luo, Hao Huang, Chun-Ying Li, Dong-Xu Liu, Xiang-Qian Liu
Summary: Phytochemical investigation of Dryopteris crassirhizoma led to the discovery of two new compounds and identification of four known compounds. The compounds exhibited inhibitory effects on inflammation, demonstrating their potential anti-inflammatory activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Kiyotaka Hori, Atsushi Ebihara, Noriaki Murakami
Summary: A molecular phylogenetic analysis of the Japanese apogamous fern Dryopteris yakusilvicola and related species revealed that its origin is not a hybrid between D. sparsa var. sparsa and D. sabaei, but likely involves undetected species closely related to D. melanocarpa var. elegans and D. sabaei. Further analysis of additional species in the D. sparsa complex and more nuclear markers are needed to clarify the relationships within this complex.
Article
Chemistry, Medicinal
Ping Hai, Yunqing He, Ruirui Wang, Yuan Gao, Xudong Wu, Xuanqin Chen, Xianyan Li, Jin Yang, Jian Yang, Rongtao Li
Summary: Nine new compounds, including six tocopherol derivatives and three acylphloroglucinol derivatives, have been isolated and characterized from a type of fern. These compounds have unique structures and exhibit significant antimicrobial activities against Candida albicans, plant pathogenic fungi, and bacteria.
Article
Biology
Yoshihiro Inatomi, Hiroyuki Uno, Mayumi Ueno, Hino Takafumi, Yuichi Osa
Summary: This study found that the grazing intensity of Dryopteris crassirhizoma was sensitive to changes in deer density and positively related to spatial variation in deer density within regions. Dryopteris crassirhizoma can be a useful indicator species for assessing the impact of deer on forest vegetation.
Article
Pharmacology & Pharmacy
Young-Hee Jin, Sangeun Jeon, Jihye Lee, Seungtaek Kim, Min Seong Jang, Chul Min Park, Jong Hwan Song, Hyoung Rae Kim, Sunoh Kwon
Summary: The rhizome of Dryopteris crassirhizoma Nakai, a traditional medicinal plant in East Asia, contains compounds with anticancer, anti-inflammatory, antibacterial, and antiviral properties. Specifically, dryocrassin ABBA and filixic acid ABA from D. crassirhizoma were found to inhibit influenza virus and main protease of SARS-CoV-2. These compounds also demonstrated inhibitory activity against SARS-CoV and MERS-CoV, indicating their broad-spectrum antiviral activity. Pharmacokinetic studies showed that dryocrassin ABBA has good stability and potential therapeutic efficacy against emerging coronavirus infections, including COVID-19.
Article
Plant Sciences
Jiang-Ping Shu, Zi-Yue Liu, Zhi-Rong Gu, Li-Jun Chen, Hong-Jin Wei, Xi-Le Zhou, Yue-Hong Yan, Rui-Jiang Wang
Summary: Dryopteris wulingshanensis, a new species found in the Wulingshan Mountains of Hunan, China, is most similar to D. jishouensis and D. gymnophylla in morphological traits, but differs in certain characteristics. Molecular phylogenetic analysis suggests that D. wulingshanensis is closely related to D. jishouensis. Due to its limited geographic range and small populations, it should be considered endangered according to the IUCN Red List criteria.
Article
Plant Sciences
Yi Zhu, Junlin Wang, Lu Tang, Yuxin Shang, Weiyi Zhao, Wei Zhang, Ping Hai, Yongbiao Zheng, Wenbo Li, Yanfang Su
Summary: One new iridoid glucoside and two new lignan glycosides, along with three known compounds, were isolated from the whole plants of Lancea tibetica. The structures were determined by spectroscopic methods and X-ray crystallographic analysis. One of the new iridoid glucosides and the known compounds exhibited moderate antioxidant activity.
PHYTOCHEMISTRY LETTERS
(2024)
Article
Plant Sciences
Yi Deng, Minghua Chen, Junming Yi, Yuguo Zheng
Summary: This study successfully designed and synthesized a series of quinazolinone derivatives containing purine molecules, and found that some compounds exhibited strong antiviral activity against tobacco mosaic virus. The findings have important implications for further development of antiviral drugs.
PHYTOCHEMISTRY LETTERS
(2024)
