Journal
PHYTOCHEMISTRY
Volume 148, Issue -, Pages 21-28Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2018.01.010
Keywords
Drechmeria sp.; Indole diterpenoids; Theoretical calculation; Antimicrobial activity
Categories
Funding
- Major Science and Technique Program in Yunnan Province [2016ZF001-001, 2017IB038]
- Yung-Chi Cheng academician workstation of Yunnan provincial academy of science and technology [2015IC017]
- National Science and Technology Major Project [2017ZX09305001-002]
- National Natural Science Foundation of China [81703679, 81622047]
- Dalian Outstanding Youth Science and Technology Talent [2015J12JH201]
- Liaoning Province
- Dalian Medical University
- Natural Science Foundation of Institute of Integrative Medicine, Dalian Medical University [ICIM2017001]
- Liaoning BaiQianWan Talents Program
Ask authors/readers for more resources
A fungal strain, Drechmeria sp., was isolated from the root of Panax notoginseng. Totally, seven new indole diterpenoids, drechmerins A-G (1-7), were isolated from the fermentation broth of Drechmeria sp. together with four known analogues (8-11). Their structures were determined on the basis of 1D and 2D NMR and electronic circular dichroism (ECD) spectroscopic analyses as well as theoretical calculations. All the isolated compounds were evaluated for their antimicrobial activities against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin B (2) displayed antimicrobial activity against C. albicans with an MIC value of 12.5 mu g/mL. Molecular docking was used to investigate interactions of peptide deformylase with compounds 1-3, 5-7, 9, and 10. (C) 2018 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
