Journal
PHYTOCHEMISTRY
Volume 145, Issue -, Pages 68-76Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2017.10.009
Keywords
Mappianthus iodoides Hand-Mazz; Icacinaceae; Monoterpenoid indole alkaloids; Cytotoxic activities
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Funding
- National Natural Science Foundation of China [81402817, 21431001, 81760626]
- Innovation Fund of the Ministry of Education [IRT_16R15]
- Natural Science Foundation of Guangxi [2016GXNSFGA380005, 2014GXNSFBA118189]
- project of the State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources [CMEMR2016-A02]
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Five previously undescribed monoterpenoid indole alkaloids, mappianines A-E, along with twelve known analogues, were isolated from the stems of Mappianthus iodoides Hand.-Mazz. Their structures and absolute configurations were determined by spectroscopic analysis, single-crystal X-ray diffraction, and ECD calculations. The plausible biogenetic pathway of mappianine A was proposed. All the isolated compounds were evaluated for their cytotoxic effects on MGC-803, Bel-7404, A549, NCI-H460, and HepG2 cancer cell lines. Mappianine B, tetrahydroalstonine, beta-carbolin-1-one, and 1,2,3,4-tetrahydronorharman-1-one displayed moderate cytotoxicity against all cell lines tested, with IC50 values ranging from 5.19 to 42.86 mu M. (C) 2017 Elsevier Ltd. All rights reserved.
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