Journal
PHYTOCHEMISTRY
Volume 97, Issue -, Pages 88-95Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2013.10.011
Keywords
Delphinium trichophorum Franch; Ranunculaceae; Diterpenoid alkaloid; Hetisane-type diterpenoid alkaloid; Delnudine-type diterpenoid alkaloid
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Funding
- International Cooperation Fund in Guangdong Province [2008A050200005]
- Tibetan Medicine Quality Standardization by Tibet Department of Science [2007-2-10]
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Five hetisane-type C-20-diterpenoid alkaloids, trichodelphinines A-E, one delnudine-type C-20-diterpenoid alkaloid, trichodelphinine F and three known flavonoids, quercetin, quercetin 3-O-beta-D-glucopyranoside, and quercetin 3-O-beta-D-glucopyranoside-7-O-alpha-L-arabinopyranoside, were isolated from whole plants of Delphinium trichophorum Franch. Their structures were elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC, H-1-H-1 COSY, NOESY and X-ray crystallographic analysis, and from chemical evidence. The cytotoxic activities of the diterpenoid alkaloids were evaluated using the MTT method, and the IC50 values of their cytotoxicity against A549 cancer cells ranged from 12.03 to 52.79 mu M. (C) 2013 Elsevier Ltd. All rights reserved.
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