Journal
PHYTOCHEMISTRY
Volume 74, Issue -, Pages 133-139Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.11.008
Keywords
Allium; Onion; Saponins; Furostanol-type; Ceposides; Antifungal activity; Structure-activity relationships
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Three saponins, named ceposide A, ceposide B, and ceposide C were isolated from the bulbs of white onion, Allium cepa L. Elucidation of their structure was carried out by comprehensive spectroscopic analyses, including 2D NMR spectroscopy and mass spectrometry, and chemical evidences. The structures of the compounds were identified as (25R)-furost-5(6)-en-1 beta,3 beta,22 alpha,26-tetraol 1-O-beta-D-xylopyr anosyl 26-O-alpha-D-rhamnoyranosyl-(1 -> 2)-O-beta-D-galactopyranoside (ceposide A), (25R)-furost-5(6)-en-1 beta,3 beta,22 alpha,26-tetraol 1-O-beta-D-xylopyranosyl 26-O-alpha-D-rhamnoyranosyl-(1 -> 2)-O-beta-D-glucopyranoside (ceposide B), and (25R)-furost-5(6)-en-1 beta,3 beta,22 alpha,26-tetraol 1-O-beta-D-galactopyranosyl 26-O-alpha-D-rhamnoyranosyl-(1 -> 2)-O-beta-D-galactopyranoside (ceposide C). The isolated compounds, alone and in combinations, were evaluated for their antimicrobial activity on ten fungal species. Antifungal activity of all three saponins increased with their concentration and varied with the following rank: ceposide B > ceposide A-ceposide C. We found a significant synergism in the antifungal activity of the three ceposides against Bonytis cinerea and Trichoderma atroviride, because growth of these fungi was strongly inhibited when the three saponins were applied in combination. In contrast, Fusarium oxysporum f. sp. lycopersici, Sclerotium cepivorum and Rhizoctonia solani were very little affected by saponins. (C) 2011 Elsevier Ltd. All rights reserved.
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