Journal
PHYTOCHEMISTRY
Volume 75, Issue -, Pages 67-77Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.11.012
Keywords
Aesculus glabra; Hippocastanaceae; Triterpenoid saponins; Cytotoxicity; Aesculioside; Chemotaxonomy
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Funding
- USDA [2008-38928-19308, 2009-38928-19744]
- W.M. Keck Foundation
- University of Houston
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Twenty-four acylated polyhydroxyoleanene saponins were isolated from the seeds of Aesculus glabra. Sixteen of them, namely aesculiosides G1-G16 (1-16), were determined as compounds by spectroscopic and chemical analysis. The structural features of all 24 saponins are: (1) arabinofuranosyl units affixed to C-3 of the glucuronopyranosyl unit in the trisaccharide chain; (2) no 24-OH substitution: (3) C-2 sugar moiety substitution of the 3-O-glucuronopyranosyl unit is either glucopyranosyl or galactopyranosyl. The features of these isolated saponin structures provide more evidence for chemical taxonomy within the genus Aesculus. The cytotoxicity of the aesculiosides (1-16) were tested against A549 and PC-3 cancer cell lines with GI(50) from 5.4 to >25 mu M. (C) 2011 Elsevier Ltd. All rights reserved.
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