Journal
PHYTOCHEMISTRY
Volume 80, Issue -, Pages 115-122Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.04.017
Keywords
Dryopteris wallichiana (Spreng.) Hyl.; Dryopteridaceae; Terpenylated acylphloroglucinols; Nematocidal activity; Nippostrongylus brasiliensis
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- ANPCyT
- CONICET
- CIUNT, Argentina
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Four unusual terpenylated acylphloroglucinols were isolated from the diethyl ether extract of the scales and rhizomes of the fern Dryopteris wallichiana together with the known compounds albaspidins AA and AB, and filixic acids ABA and ABB. Structures of the isolated compounds were established by extensive spectroscopic analysis and their absolute configuration at C-14 '' was determined by comparing their CD spectra with those simulated for the respective isomers. Pure acylphloroglucinols displayed moderate in vitro nematocidal activity against L4 stage larvae of Nippostrongylus brasiliensis (LD50= 22-121 mu M). (C) 2012 Elsevier Ltd. All rights reserved.
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