Article
Chemistry, Applied
FanCheng Meng, XiaoDong Wei, Yan Sun, QingHong Zeng, Guowei Wang, XiaoZhong Lan, ZhiHua Liao, Min Chen
Summary: Two new cycloartane glycosides and a new oleanolic acid glycoside were isolated from Thalictrum atriplex and their structures were determined through extensive NMR and HR-ESI-MS analyses. One of the compounds exhibited cytotoxicity against human breast cancer cells MDA-MB-231.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Rositsa Mihaylova, Aleksandar Shkondrov, Denitsa Aluani, Iliana Ionkova, Virginia Tzankova, Ilina Krasteva
Summary: The study evaluated the anticancer and immunomodulating properties of saponins extracted from Astragalus, showing inhibitory effects on tumor models and significant immune-stimulating effects on immune cells in mice. Results demonstrated the potential of these saponins for cancer treatment and immune system modulation.
BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
(2021)
Article
Biochemistry & Molecular Biology
Xiangyuan Li, Zixuan Zhao, Zhaocui Sun, Zhonghao Sun, Guoxu Ma, Xiaohong Zhao, Xudong Xu, Meihua Yang, Xianjin Wu, Haifeng Wu, Qiongyu Zou, Ji Zhang
Summary: A phytochemical investigation of Actaea vaginata led to the discovery of two new cycloartane triterpenoid saponins, as well as the evaluation of their cytotoxic activities against hepatocellular carcinoma cells.
CARBOHYDRATE RESEARCH
(2022)
Article
Food Science & Technology
Le Ba Vinh, Yoo Kyong Han, Si Young Park, Young Jun Kim, Nguyen Viet Phong, Eunji Kim, Bong-geun Ahn, Yong Woo Jung, Youngjoo Byun, Young Ho Jeon, Ki Yong Lee
Summary: In our research, we discovered that an ethanol extract from the roots of Astragalus membranaceus has a significant inhibitory effect on interleukin-33 (IL-33), suggesting potential pharmacological anti-allergic effects.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Chemistry, Medicinal
Thi Dieu Huong Hoang, Thi Kim Van Le, Thi Ha Do
Summary: Seven new triterpene glycosides were isolated from the extract of Elsholtzia penduliflora, and two of them showed significant cytotoxicity against human lung and breast cancer cells.
Article
Biotechnology & Applied Microbiology
Kuan Chen, Meng Zhang, Baihan Gao, Aobulikasimu Hasan, Junhao Li, Yang'oujie Bao, Jingjing Fan, Rong Yu, Yang Yi, Hans Agren, Zilong Wang, Haiyang Liu, Min Ye, Xue Qiao
Summary: In this study, glycosyltransferases (GT) from Astragalus membranaceus were studied to synthesize structurally diverse astragalosides, providing new biocatalytic tools for saponin biosynthesis.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Chemistry, Applied
Manzura A. Agzamova, Nilufar Z. Mamadalieva, Andrea Porzel, Hidayat Hussain, Mthandazo Dube, Katrin Franke, Abdulaziz Janibekov, Ludger A. Wessjohann
Summary: In this study, a new cycloartane triterpene glycoside, named lehmanniaside, was isolated and identified from the aerial parts of Astragalus lehmannianus Bunge. Its structure was determined through spectroscopic analysis, and it exhibited weak anthelmintic, antifungal, and cytotoxic activities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Khouloud Nafti, Geraldine Giacinti, Sonia Marghali, Christine Delgado Raynaud
Summary: The extraction and isolation of saponins from plants are challenging due to their unique structural characteristics. This study successfully implemented specific extraction protocols to obtain secondary metabolites, particularly saponins, from Astragalus hamosus. The extracts were then purified using high-performance thin-layer chromatography with one-step and multiple development systems, and the triterpenoid saponins, azukisaponin, or soyasapogenol were detected at a retarded Rf of 0.2.
Article
Plant Sciences
Minju Gal, Okwha Kim, Phuong Thao Tran, Le Thanh Huong, Nguyen Xuan Nhiem, Phan Van Kiem, Nguyen Hai Dang, Jeong-Hyung Lee
Summary: This study demonstrated that mussaendoside O has the ability to inhibit the differentiation of cells into osteoclasts induced by RANKL and can suppress LPS-induced bone resorption. The underlying mechanism involves the inhibition of the RANKL-activated c-Fos/NFATc1 signaling pathway.
Article
Chemistry, Applied
Yi-ting Wang, Shi-rui Fan, Jie-yun Cai, Jing-jing Guo, Xin-fang Zhang, Bi-juan Yang, Xiao-jiang Hao, Duo-zhi Chen
Summary: Two new cycloartane triterpenoids were isolated from leaves and twigs of Aphanamixis polystachya, with one compound showing cytotoxic activity on all tested human cancer cell lines and the other exhibiting specific activity on one cell line.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Tran Thi Hong Hanh, Pham Thi Cham, Do Hoang Anh, Nguyen The Cuong, Nguyen Quang Trung, Tran Hong Quang, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh
Summary: Phytochemical investigation of a methanol extract of Panax pseudoginseng flower buds led to the discovery of three new dammarane-type triterpenoid saponins, with cytotoxic effects observed on various human carcinoma cell lines.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ivan Stambolov, Aleksandar Shkondrov, Olaf Kunert, Franz Bucar, Magdalena Kondeva-Burdina, Ilina Krasteva
Summary: Astragalus glycyphyllos is a plant used in traditional medicine for liver and heart disorders. It contains flavonoids and saponins. Two saponins, including a new triterpenoid saponin, were isolated from the plant and tested for antioxidant and neuroprotective activity in vitro.
Article
Chemistry, Applied
Pham Hai Yen, Nguyen Thi Hong Chuong, Giang Thi Kim Lien, Nguyen Thi Cuc, Nguyen Xuan Nhiem, Nguyen Thi Viet Thanh, Bui Huu Tai, Yohan Seo, Wan Namkung, SeonJu Park, Seung Hyun Kim, Chau Van Minh, Phan Van Kiem
Summary: Two new aramatosides and seven known oleanane-type triterpene saponins were isolated from the leaves of Aralia armata. Some of these compounds exhibited cytotoxic effects on human cancer cell lines, with one compound showing significant cytotoxic activity against two specific cell lines.
NATURAL PRODUCT RESEARCH
(2022)
Article
Immunology
Nilgun Yakubogullari, Ali Cagir, Erdal Bedir, Duygu Sag
Summary: Astragaloside VII (AST VII), a triterpenic saponin, has potential as a vaccine adjuvant due to its ability to promote a balanced Th1/Th2 immune response. However, the underlying mechanisms of its adjuvant activity have not been fully understood. This study investigated the effects of AST VII and its analogs on human whole blood cells and mouse bone marrow-derived dendritic cells (BMDCs). The results demonstrate that AST VII and its derivatives enhance pro-inflammatory responses, support dendritic cell maturation, and activate T cells in vitro.
Article
Biochemistry & Molecular Biology
Anton Hinkov, Venelin Tsvetkov, Aleksandar Shkondrov, Ilina Krasteva, Stoyan Shishkov, Kalina Shishkova
Summary: Members of the family Coronaviridae can cause diseases in various animals, including humans. Research on the antiviral activities of medicinal herbs and crops with different ethnobotanical backgrounds has been extensive. This study focuses on the antiviral effect of Astragalus glycyphyllos L. and its purified saponin mixture on viral replication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Fadime Aydogan, Sura Baykan, Gamal A. Soliman, Hasan Yusufoglu, Erdal Bedir
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Plant Sciences
Tugba Gunbatan, Ilhan Gurbuz, Erdal Bedir, Ayse Mine Gencler Ozkan, Ozge Ozcinar
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Chemistry, Physical
Fadime Aydogan, El Hassane Anouar, Muhittin Aygun, Hasan Yusufoglu, Canan Karaalp, Erdal Bedir
Summary: The study isolated multiple known compounds and new compounds from the roots and aerial parts of Teucrium sandrasicum plant, elucidating their structures through various analysis methods and testing their cytotoxic activities experimentally.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemical Research Methods
Nilgun Yakubogullari, Furkan Ozan Coven, Nusin Cebi, Fethiye Coven, Nejdet Coven, Rukan Genc, Erdal Bedir, Ayse Nalbantsoy
Summary: AST-VII and AST-VII containing adjuvant systems demonstrated Th1/Th2 balanced antibody and cellular immune responses in NDV vaccines.
Article
Plant Sciences
Cigdem Karakoyun, Melis Kucuksolak, Eyup Bilgi, Gamze Dogan, Yigit Ege Comlekci, Erdal Bedir
Summary: Endophytic fungi were found to biotransform oleandrin and nerigoside, leading to the isolation of five new metabolites with two exhibiting potent cytotoxic activity. This study provides important clues for investigating the toxicity mechanisms of these compounds.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Seda Duman, Guner Ekiz, Sinem Yilmaz, Hasan Yusufoglu, Petek Ballar Kirmizibayrak, Erdal Bedir
Summary: Biotransformation of 20(27)-octanor-cycloastragenol by endophytic fungi from Astragalus genus resulted in 15 new transformation products, some of which showed significant telomerase activation effects.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Erdal Bedir, Cigdem Karakoyun, Gamze Dogan, Gulten Kuru, Melis Kucuksolak, Hasan Yusufoglu
Summary: Microbial biotransformation of a cytotoxic cardenolide using the endophytic fungus Alternaria eureka resulted in the generation of new metabolites with lower cytotoxicity than the substrate. Among these metabolites, compound 8 exhibited the highest activity against lung cancer cell lines, indicating its potential therapeutic value.
Article
Plant Sciences
Semiha Cetinel Aksoy, Melis Kucuksolak, Atac Uzel, Erdal Bedir
Summary: A new natural product with pyrrolobenzodiazepine (PBD) framework, 7-methoxy-8-hydroxy cycloanthranilylproline (2), was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, along with cycloanthranilylproline (1). The compounds were structurally elucidated using various analytical techniques and showed notable antimicrobial activity. This study demonstrated the presence of PBD derivatives in S. cacaoi for the first time.
RECORDS OF NATURAL PRODUCTS
(2021)
Article
Plant Sciences
Mehmet Sina Icen, Ilhan Gurbuz, Erdal Bedir, Tugba Gunbatan, Fatih Demirci
Summary: Salvia palaestina aqueous and methanol extracts were evaluated for in vitro anti-inflammatory properties, with methanol extract showing significant lipoxygenase inhibition. Ethyl acetate fraction from activity guided fractionation exhibited the best inhibition, and compounds responsible for the activity were identified as rosmarinic acid and methyl rosmarinate.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Emre Gezer, Goklem Uner, Melis Kucuksolak, Mustafa Unver Kurt, Gamze Dogan, Petek Ballar Kirmizibayrak, Erdal Bedir
Summary: Polyether ionophores are a group of naturally occurring compounds mainly produced by Streptomyces species with various bioactivities. In this study, four undescribed and nine known polyether compounds were identified from Streptomyces cacaoi. The antimicrobial activity assays showed strong inhibitory effects of these compounds, including an undescribed compound, on the growth of Bacillus subtilis and methicillin-resistant Staphylococcus aureus (MRSA). Additionally, two compounds displayed significant cytotoxicity, with the C15-demethoxy derivative showing higher selectivity towards cancer cells than K41-A. Mechanistic experiments revealed that the uninvestigated compound acts as a multitarget compound, inhibiting autophagic flux, inducing reactive oxygen species formation, abolishing proteasome activity, and stimulating ER stress.
Article
Plant Sciences
Gulten Kuru, Goklem Uner, Erdal Bedir
Summary: There is a high demand for novel approaches to treat age-related diseases, which are a major cause of death worldwide. Dysfunctional telomeres, which accelerate the aging process, are associated with many of these diseases. Telomerase, an enzyme responsible for maintaining healthy telomeres, has shown promise as a target for treatment. Natural products containing telomerase activators have protective and therapeutic effects against age-related diseases, particularly neurodegenerative, cardiovascular, and osteodegenerative disorders. However, the role of telomerase activation is often overlooked in studies.
PHYTOCHEMISTRY REVIEWS
(2023)
Article
Plant Sciences
Fadime Aydogan, Zulfiqar Ali, Fazila Zulfiqar, Canan Karaalp, Ikhlas A. Khan, Erdal Bedir
Summary: Fifteen new neo-clerodane diterpenoids, including two undescribed glycosides, as well as a known iridoid glycoside and a phenylpropanoid glycoside, were isolated from the whole plant of Teucrium divaricatum subsp. divaricatum. Their structures were determined through spectral data analysis, and their anti-inflammatory and antimicrobial activities were evaluated. The compounds showed no significant antimicrobial activity against various bacterial and fungal strains, and were inactive up to the highest tested concentration of 50 μM on iNOS inhibitory activity.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Immunology
Nilgun Yakubogullari, Ali Cagir, Erdal Bedir, Duygu Sag
Summary: Astragaloside VII (AST VII), a triterpenic saponin, has potential as a vaccine adjuvant due to its ability to promote a balanced Th1/Th2 immune response. However, the underlying mechanisms of its adjuvant activity have not been fully understood. This study investigated the effects of AST VII and its analogs on human whole blood cells and mouse bone marrow-derived dendritic cells (BMDCs). The results demonstrate that AST VII and its derivatives enhance pro-inflammatory responses, support dendritic cell maturation, and activate T cells in vitro.
Article
Chemistry, Medicinal
Goklem Uner, Ozgur Tag, Yalcin Erzurumlu, Petek Ballar Kirmizibayrak, Erdal Bedir
CHEMICAL RESEARCH IN TOXICOLOGY
(2020)
Article
Plant Sciences
Ozge Guzel, Seda Duman, Sinem Yilmaz, Cigdem Karakoyun, Demet Kul, Ademi Fahri Pirhan, Erdal Bedir
Summary: This study evaluated the cytotoxic effects and topoisomerase inhibitory activities of certain Onosma species in southwestern Turkey, identifying several species with strong anticancer activity. The findings suggest the significant role of Onosma species in the field of anticancer drug discovery.
TURKISH JOURNAL OF BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Armando Moreno-Velasco, Mabel Fragoso-Serrano, Pedro de Jesus Flores-Tafoya, Sebastian Carrillo-Rojas, Elihu Bautista, Suzana Guimara Leitao, Jhon F. Castaneda-Gomez, Rogelio Pereda-Miranda
Summary: This study investigated the roots of Operculina hamiltonii, a traditional medicinal plant in Brazil. Three new acyl sugars or resin glycosides were identified and their structures elucidated. The combination of these compounds with other drugs showed enhanced cytotoxic effects on breast cancer cells.
Article
Biochemistry & Molecular Biology
Qian-Qing Liu, Lin-An Xiong, Jia-Yu Qian, Ting-Ting Gong, Lie-Feng Ma, Luo Fang, Zha-Jun Zhan
Summary: A new naturally occurring compound, Linderagatins C-F (1-4), with the structures of diaryltetrahydrofuran-type 7,9'-dinorlignans, was discovered in the roots of Lindera aggregata. The neuroprotective effects of compounds 2 and 3 on erastin-induced ferroptosis in HT-22 cells were found to be significant.
