Journal
PHYTOCHEMISTRY
Volume 72, Issue 4-5, Pages 385-390Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.01.017
Keywords
Maytenus cuzcoina; Crossopetalum uragoga; ent-Rosane; Abietane; Epstein-Barr virus; Two-stage carcinogenesis; Chemopreventive agents
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Funding
- Agencia Canaria de Investigacion, Innovacion y Sociedad de la Informacion [C200801000049]
- PCI-Iberoamerica [A/023081/09]
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Two ent-rosane-(cuzcol, 1 and 6-dehydroxycuzcol, 2) and a abietatriene-(salvadoriol, 3) type diterpenoids have been isolated from Maytenus cuzcoina and Crossopetalum uragoga, respectively, along with five known diterpene compounds (4-8). Their stereostructures have been elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR techniques, and computational data. The absolute configuration of cuzcol was determined by application of Riguera ester procedure. This is the first instance of isolation of ent-rosane diterpenoids from species of the Celastraceae. The isolated diterpenes were found to be potent anti-tumour-promoter agents, and carnosol (7) also showed a remarkable chemopreventive effect in an in vivo two-stage carcinogenesis model. (C) 2011 Elsevier Ltd. All rights reserved.
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